Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

Komal Smriti, Meenakshi Ray, Tilottama Chatterjee, Revathi Panduranga Shenoy, Srikanth Gadicherla, Kalyana Chakravarthy Pentapati, Nasrullah Rustaqi

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To compare the salivary MMP - 9 concentration among subjects with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD), tobacco users, and control groups. MATERIALS AND METHODS: A total of 88 subjects were enrolled and divided into four study groups viz., OSCC (n=24), OPMD (n=20), tobacco habits (n=22), and healthy controls (n=22). All subjects gave unstimulated saliva samples for the evaluation MMP - 9 by ELISA kit. Demographic information like age, gender, type of tobacco, and duration of the habit were recorded. RESULTS: Subjects with OSCC and OPMD had significantly higher mean MMP-9 levels than subjects with tobacco habits and control groups (P<0.001). Also, poorly differentiated OSCC group had significantly higher mean saliva MMP-9 than moderate and well-differentiated OSCC. The optimal cut-off point was 214.37 ng/mL with a sensitivity of 100% and specificity of 59% for OSCC versus the control group. The optimal cut-off point was as 205.87 ng/mL with a sensitivity of 100% and a specificity of 54% for OPMD versus the control group. CONCLUSION: The data obtained from this study indicated that OSCC and OPMD had an increased level of salivary MMP-9. Salivary MMP-9 could be a useful, non-invasive adjunct technique in the diagnosis, treatment, and follow-up of OSCC and OPMD. 
.

Original languageEnglish
Pages (from-to)233-238
Number of pages6
JournalAsian Pacific journal of cancer prevention : APJCP
Volume21
Issue number1
DOIs
Publication statusPublished - 01-01-2020

Fingerprint

Oral Diagnosis
Matrix Metalloproteinases
Squamous Cell Carcinoma
Biomarkers
Tobacco
Habits
Control Groups
Saliva
Enzyme-Linked Immunosorbent Assay
Demography
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

@article{bd198d18984d4a5dbc0db2720481a11b,
title = "Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma",
abstract = "OBJECTIVE: To compare the salivary MMP - 9 concentration among subjects with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD), tobacco users, and control groups. MATERIALS AND METHODS: A total of 88 subjects were enrolled and divided into four study groups viz., OSCC (n=24), OPMD (n=20), tobacco habits (n=22), and healthy controls (n=22). All subjects gave unstimulated saliva samples for the evaluation MMP - 9 by ELISA kit. Demographic information like age, gender, type of tobacco, and duration of the habit were recorded. RESULTS: Subjects with OSCC and OPMD had significantly higher mean MMP-9 levels than subjects with tobacco habits and control groups (P<0.001). Also, poorly differentiated OSCC group had significantly higher mean saliva MMP-9 than moderate and well-differentiated OSCC. The optimal cut-off point was 214.37 ng/mL with a sensitivity of 100{\%} and specificity of 59{\%} for OSCC versus the control group. The optimal cut-off point was as 205.87 ng/mL with a sensitivity of 100{\%} and a specificity of 54{\%} for OPMD versus the control group. CONCLUSION: The data obtained from this study indicated that OSCC and OPMD had an increased level of salivary MMP-9. Salivary MMP-9 could be a useful, non-invasive adjunct technique in the diagnosis, treatment, and follow-up of OSCC and OPMD. .",
author = "Komal Smriti and Meenakshi Ray and Tilottama Chatterjee and Shenoy, {Revathi Panduranga} and Srikanth Gadicherla and Pentapati, {Kalyana Chakravarthy} and Nasrullah Rustaqi",
year = "2020",
month = "1",
day = "1",
doi = "10.31557/APJCP.2020.21.1.233",
language = "English",
volume = "21",
pages = "233--238",
journal = "Asian Pacific Journal of Cancer Prevention",
issn = "1513-7368",
publisher = "Asian Pacific Organization for Cancer Prevention",
number = "1",

}

Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma. / Smriti, Komal; Ray, Meenakshi; Chatterjee, Tilottama; Shenoy, Revathi Panduranga; Gadicherla, Srikanth; Pentapati, Kalyana Chakravarthy; Rustaqi, Nasrullah.

In: Asian Pacific journal of cancer prevention : APJCP, Vol. 21, No. 1, 01.01.2020, p. 233-238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Salivary MMP-9 as a Biomarker for the Diagnosis of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma

AU - Smriti, Komal

AU - Ray, Meenakshi

AU - Chatterjee, Tilottama

AU - Shenoy, Revathi Panduranga

AU - Gadicherla, Srikanth

AU - Pentapati, Kalyana Chakravarthy

AU - Rustaqi, Nasrullah

PY - 2020/1/1

Y1 - 2020/1/1

N2 - OBJECTIVE: To compare the salivary MMP - 9 concentration among subjects with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD), tobacco users, and control groups. MATERIALS AND METHODS: A total of 88 subjects were enrolled and divided into four study groups viz., OSCC (n=24), OPMD (n=20), tobacco habits (n=22), and healthy controls (n=22). All subjects gave unstimulated saliva samples for the evaluation MMP - 9 by ELISA kit. Demographic information like age, gender, type of tobacco, and duration of the habit were recorded. RESULTS: Subjects with OSCC and OPMD had significantly higher mean MMP-9 levels than subjects with tobacco habits and control groups (P<0.001). Also, poorly differentiated OSCC group had significantly higher mean saliva MMP-9 than moderate and well-differentiated OSCC. The optimal cut-off point was 214.37 ng/mL with a sensitivity of 100% and specificity of 59% for OSCC versus the control group. The optimal cut-off point was as 205.87 ng/mL with a sensitivity of 100% and a specificity of 54% for OPMD versus the control group. CONCLUSION: The data obtained from this study indicated that OSCC and OPMD had an increased level of salivary MMP-9. Salivary MMP-9 could be a useful, non-invasive adjunct technique in the diagnosis, treatment, and follow-up of OSCC and OPMD. .

AB - OBJECTIVE: To compare the salivary MMP - 9 concentration among subjects with oral squamous cell carcinoma (OSCC), oral potentially malignant disorders (OPMD), tobacco users, and control groups. MATERIALS AND METHODS: A total of 88 subjects were enrolled and divided into four study groups viz., OSCC (n=24), OPMD (n=20), tobacco habits (n=22), and healthy controls (n=22). All subjects gave unstimulated saliva samples for the evaluation MMP - 9 by ELISA kit. Demographic information like age, gender, type of tobacco, and duration of the habit were recorded. RESULTS: Subjects with OSCC and OPMD had significantly higher mean MMP-9 levels than subjects with tobacco habits and control groups (P<0.001). Also, poorly differentiated OSCC group had significantly higher mean saliva MMP-9 than moderate and well-differentiated OSCC. The optimal cut-off point was 214.37 ng/mL with a sensitivity of 100% and specificity of 59% for OSCC versus the control group. The optimal cut-off point was as 205.87 ng/mL with a sensitivity of 100% and a specificity of 54% for OPMD versus the control group. CONCLUSION: The data obtained from this study indicated that OSCC and OPMD had an increased level of salivary MMP-9. Salivary MMP-9 could be a useful, non-invasive adjunct technique in the diagnosis, treatment, and follow-up of OSCC and OPMD. .

UR - http://www.scopus.com/inward/record.url?scp=85078357086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85078357086&partnerID=8YFLogxK

U2 - 10.31557/APJCP.2020.21.1.233

DO - 10.31557/APJCP.2020.21.1.233

M3 - Article

C2 - 31983189

AN - SCOPUS:85078357086

VL - 21

SP - 233

EP - 238

JO - Asian Pacific Journal of Cancer Prevention

JF - Asian Pacific Journal of Cancer Prevention

SN - 1513-7368

IS - 1

ER -