Screening of anticancer activity of selected medicinal plants indigenous to Western Ghats: Argyreia nervosa, Memecylon malabaricum and Memecylon umbellatum

Shilpee Chaudhary, Kodangala Subraya Chandrashekar, Karkala Sreedhara Ranganath Pai, M. M. Setty, Raviraj Anand Devkar, Neetinkumar Dnyanoba Reddy, Subhankar Biswas

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The present study was undertaken to evaluate the in vitro anticancer potential of selected medicinal plants; leaves (ANL) and seeds (ANS) of Argyreia nervosa, Memecylon malabaricum (MML), and Memecylon umbellatum (MUL) in colon cancer cells. In addition, the extracts were tested for their selectivity towards cancer cells as compared to normal cells. The cell growth inhibition was tested by sulforhodamine assay in both cancer and normal cells at various concentrations. The extracts exhibited dose-dependent cytotoxicity in both cells with varying indices of selectivity. Among the tested extracts, MUL was found to exhibit the highest cytotoxicity in HCT-116 cells with an IC50 of 276.63±11.75 μg/mL followed by ANL, MML, and ANS. The selectivity was also found to be most favorable in MUL. MUL also demonstrated apoptosis, the preferred mode of cell death for anticancer agents in HCT-116 by acridine orange/ethidium bromide (AO/EB) staining. Taken together, our results demonstrate that Memecylon umbellatum can act as a lead for the development of potential anticancer agents with selectivity towards cancer cells.

Original languageEnglish
Pages (from-to)1781-1784
Number of pages4
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017

Fingerprint

medicinal plant
Medicinal Plants
Screening
cancer
Cells
Cell death
Cytotoxicity
Seed
Cell
Selectivity
Cancer
Cell growth
seed
Assays
apoptosis
Antineoplastic Agents
Lead
bromide
HCT116 Cells
Neoplasms

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Computer Science(all)
  • Education
  • Mathematics(all)
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

Cite this

@article{3d43caee2bad4a508536d33c1d26d70b,
title = "Screening of anticancer activity of selected medicinal plants indigenous to Western Ghats: Argyreia nervosa, Memecylon malabaricum and Memecylon umbellatum",
abstract = "The present study was undertaken to evaluate the in vitro anticancer potential of selected medicinal plants; leaves (ANL) and seeds (ANS) of Argyreia nervosa, Memecylon malabaricum (MML), and Memecylon umbellatum (MUL) in colon cancer cells. In addition, the extracts were tested for their selectivity towards cancer cells as compared to normal cells. The cell growth inhibition was tested by sulforhodamine assay in both cancer and normal cells at various concentrations. The extracts exhibited dose-dependent cytotoxicity in both cells with varying indices of selectivity. Among the tested extracts, MUL was found to exhibit the highest cytotoxicity in HCT-116 cells with an IC50 of 276.63±11.75 μg/mL followed by ANL, MML, and ANS. The selectivity was also found to be most favorable in MUL. MUL also demonstrated apoptosis, the preferred mode of cell death for anticancer agents in HCT-116 by acridine orange/ethidium bromide (AO/EB) staining. Taken together, our results demonstrate that Memecylon umbellatum can act as a lead for the development of potential anticancer agents with selectivity towards cancer cells.",
author = "Shilpee Chaudhary and Chandrashekar, {Kodangala Subraya} and Pai, {Karkala Sreedhara Ranganath} and Setty, {M. M.} and Devkar, {Raviraj Anand} and Reddy, {Neetinkumar Dnyanoba} and Subhankar Biswas",
year = "2017",
month = "3",
day = "1",
doi = "10.1166/asl.2017.8510",
language = "English",
volume = "23",
pages = "1781--1784",
journal = "Advanced Science Letters",
issn = "1936-6612",
publisher = "American Scientific Publishers",
number = "3",

}

Screening of anticancer activity of selected medicinal plants indigenous to Western Ghats : Argyreia nervosa, Memecylon malabaricum and Memecylon umbellatum. / Chaudhary, Shilpee; Chandrashekar, Kodangala Subraya; Pai, Karkala Sreedhara Ranganath; Setty, M. M.; Devkar, Raviraj Anand; Reddy, Neetinkumar Dnyanoba; Biswas, Subhankar.

In: Advanced Science Letters, Vol. 23, No. 3, 01.03.2017, p. 1781-1784.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Screening of anticancer activity of selected medicinal plants indigenous to Western Ghats

T2 - Argyreia nervosa, Memecylon malabaricum and Memecylon umbellatum

AU - Chaudhary, Shilpee

AU - Chandrashekar, Kodangala Subraya

AU - Pai, Karkala Sreedhara Ranganath

AU - Setty, M. M.

AU - Devkar, Raviraj Anand

AU - Reddy, Neetinkumar Dnyanoba

AU - Biswas, Subhankar

PY - 2017/3/1

Y1 - 2017/3/1

N2 - The present study was undertaken to evaluate the in vitro anticancer potential of selected medicinal plants; leaves (ANL) and seeds (ANS) of Argyreia nervosa, Memecylon malabaricum (MML), and Memecylon umbellatum (MUL) in colon cancer cells. In addition, the extracts were tested for their selectivity towards cancer cells as compared to normal cells. The cell growth inhibition was tested by sulforhodamine assay in both cancer and normal cells at various concentrations. The extracts exhibited dose-dependent cytotoxicity in both cells with varying indices of selectivity. Among the tested extracts, MUL was found to exhibit the highest cytotoxicity in HCT-116 cells with an IC50 of 276.63±11.75 μg/mL followed by ANL, MML, and ANS. The selectivity was also found to be most favorable in MUL. MUL also demonstrated apoptosis, the preferred mode of cell death for anticancer agents in HCT-116 by acridine orange/ethidium bromide (AO/EB) staining. Taken together, our results demonstrate that Memecylon umbellatum can act as a lead for the development of potential anticancer agents with selectivity towards cancer cells.

AB - The present study was undertaken to evaluate the in vitro anticancer potential of selected medicinal plants; leaves (ANL) and seeds (ANS) of Argyreia nervosa, Memecylon malabaricum (MML), and Memecylon umbellatum (MUL) in colon cancer cells. In addition, the extracts were tested for their selectivity towards cancer cells as compared to normal cells. The cell growth inhibition was tested by sulforhodamine assay in both cancer and normal cells at various concentrations. The extracts exhibited dose-dependent cytotoxicity in both cells with varying indices of selectivity. Among the tested extracts, MUL was found to exhibit the highest cytotoxicity in HCT-116 cells with an IC50 of 276.63±11.75 μg/mL followed by ANL, MML, and ANS. The selectivity was also found to be most favorable in MUL. MUL also demonstrated apoptosis, the preferred mode of cell death for anticancer agents in HCT-116 by acridine orange/ethidium bromide (AO/EB) staining. Taken together, our results demonstrate that Memecylon umbellatum can act as a lead for the development of potential anticancer agents with selectivity towards cancer cells.

UR - http://www.scopus.com/inward/record.url?scp=85018618799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018618799&partnerID=8YFLogxK

U2 - 10.1166/asl.2017.8510

DO - 10.1166/asl.2017.8510

M3 - Article

AN - SCOPUS:85018618799

VL - 23

SP - 1781

EP - 1784

JO - Advanced Science Letters

JF - Advanced Science Letters

SN - 1936-6612

IS - 3

ER -