Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities

C. Shreedhara, V. Vaidya, H. Vagdevi, K. Latha, K. Muralikrishna, A. Krupanidhi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Objectives: Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models. Materials and Methods: Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy′s hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50mg/kg and 100mg/kg. Results: The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P <0.001). The maximum analgesic effect was observed at 120 min at the dose of 100mg/kg (i.p.) and was comparable to that of standard analgin (150mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50mg/kg and 100mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5mg/kg). Conclusion: Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.
Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalIndian Journal of Pharmacology
Volume41
Issue number2
DOIs
Publication statusPublished - 2009

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Bauhinia
Non-Steroidal Anti-Inflammatory Agents
Ethanol
Analgesics
Edema
Anti-Inflammatory Agents
Central Nervous System Depressants
Dipyrone
Diclofenac
Carrageenan
Acetic Acid
Wistar Rats
Animal Models
Pharmaceutical Preparations

Cite this

Shreedhara, C., Vaidya, V., Vagdevi, H., Latha, K., Muralikrishna, K., & Krupanidhi, A. (2009). Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities. Indian Journal of Pharmacology, 41(2), 75-79. https://doi.org/10.4103/0253-7613.51345
Shreedhara, C. ; Vaidya, V. ; Vagdevi, H. ; Latha, K. ; Muralikrishna, K. ; Krupanidhi, A. / Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities. In: Indian Journal of Pharmacology. 2009 ; Vol. 41, No. 2. pp. 75-79.
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title = "Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities",
abstract = "Objectives: Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models. Materials and Methods: Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy′s hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50mg/kg and 100mg/kg. Results: The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P <0.001). The maximum analgesic effect was observed at 120 min at the dose of 100mg/kg (i.p.) and was comparable to that of standard analgin (150mg/kg) and the percentage of edema inhibition effect was 46.4{\%} and 77{\%} for 50mg/kg and 100mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5mg/kg). Conclusion: Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.",
author = "C. Shreedhara and V. Vaidya and H. Vagdevi and K. Latha and K. Muralikrishna and A. Krupanidhi",
note = "Cited By :29 Export Date: 10 November 2017 CODEN: INJPD Correspondence Address: Shreedhara, C.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: cssncp@rediffmail.com Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; alcohol, 64-17-5; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; diclofenac, 15307-79-6, 15307-86-5; dipyrone, 50567-35-6, 5907-38-0, 68-89-3 Tradenames: aspirin References: Asolker LV, Kakkar KK, Chakre OJ. Supplement to glossary of Indian medicinal plants. Part-I (A-K). National Institute of Science Communication, New Delhi: 2000. p. 116-7; Kirthikar KR, Basu DB. Indian Medicinal Plants. 4. 2 nd ed. Dehradun: Oriental Enterprises; 2000. p. 1255-7; Yadava, R.N., Tripathi, A., Novel flavone glycoside from the stem of Bauhinia purpurea (2000) Fitoterapia, 71, pp. 88-90; Salantino, A., Blatt, T.T., Foliar Flavanoids of nine species of Bauhinia (1999) Revista Brsileira de Botanica, 22, pp. 17-20; Panda, S., Kar, A., Withania Somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice (1999) J Ethnopharmacol, 67, pp. 233-239; Vijayakumari, K.P., Siddhuraru, Chemical composition, amino acid content and quality of protein in the legume of Bauhinia purpurea (1997) J Sci Food Agr, 73, pp. 279-286; Ramachandran, R., Joshi, B.C., Chemical examination of Bauhinia purpurea flowers (1967) Curr Sci, 36, pp. 574-575; Pettit, G.R., Numata, A., Iwamoto, C., Usami, Y., Yamada, T., Ohishi, H., Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea (2006) J Nat Prod, 69, pp. 323-327; Wagner, H., Baldt, S., Zgainski, E.M., Plant drug analysis. Springer Verlag (1984), pp. 126-169. , Berlin/ New York:, 291-305; Harborne, J.B., (1973) Phytochemical methods, pp. 52-105. , London: Chapman and Hall Ltd; Stahl, E., (1969) Thin layer chromatography: A laboratory hand book, pp. 206-258. , Springer International. New York; Turner, R.A., (1965) Screening methods in pharmacology, p. 158. , New York: Academic Press; Kamath, J.V., Rana, A.C., Pharmacological Activities of ethanolic extract of Calotropis procera roots (2003) Indian Drugs, 40, pp. 292-295; Sondhi SM, Nidhi Singhal, Verma RP. Synthesis, antiinflammatory and analgesic activity evaluation of some 2-(9-acridinylamino) pyridines and 2-(9-acridinyl amino/ imino) thiazolines. Indian J Chem Br 1997;36:620-4; Vane, J.R., Inhibition of Prostaglandin synthesis as a mechanism of action of Aspirin like durgs (1971) Nat New Biol, 231, p. 232; Winter, C.A., Risely, E.A., Nuss, G.W., Carragenan induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs (1962) Proc Soc Exp Bio Med, 111, pp. 544-547; Vinegar, R., Trauz, J.F., Selph, J.L., Concurrent evaluation and resolution in an acute inflammatory model of rat carrageenan-induced pleurisy (1973) Proc Soc Exp Biol Med, 143, pp. 711-714; Rajnarayana, K., Sripal reddy, M., Chaluvadi, M.R., Krishna, D.R., Preliminary studies on the anti-inflammatory effects of Swertia chirata in albino rats (1995) Indian J Pharmacol, 27, pp. 37-39",
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Shreedhara, C, Vaidya, V, Vagdevi, H, Latha, K, Muralikrishna, K & Krupanidhi, A 2009, 'Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities', Indian Journal of Pharmacology, vol. 41, no. 2, pp. 75-79. https://doi.org/10.4103/0253-7613.51345

Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities. / Shreedhara, C.; Vaidya, V.; Vagdevi, H.; Latha, K.; Muralikrishna, K.; Krupanidhi, A.

In: Indian Journal of Pharmacology, Vol. 41, No. 2, 2009, p. 75-79.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Screening of Bauhinia purpurea Linn. for analgesic and anti-inflammatory activities

AU - Shreedhara, C.

AU - Vaidya, V.

AU - Vagdevi, H.

AU - Latha, K.

AU - Muralikrishna, K.

AU - Krupanidhi, A.

N1 - Cited By :29 Export Date: 10 November 2017 CODEN: INJPD Correspondence Address: Shreedhara, C.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: cssncp@rediffmail.com Chemicals/CAS: acetic acid, 127-08-2, 127-09-3, 64-19-7, 71-50-1; acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; alcohol, 64-17-5; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; diclofenac, 15307-79-6, 15307-86-5; dipyrone, 50567-35-6, 5907-38-0, 68-89-3 Tradenames: aspirin References: Asolker LV, Kakkar KK, Chakre OJ. Supplement to glossary of Indian medicinal plants. Part-I (A-K). National Institute of Science Communication, New Delhi: 2000. p. 116-7; Kirthikar KR, Basu DB. Indian Medicinal Plants. 4. 2 nd ed. Dehradun: Oriental Enterprises; 2000. p. 1255-7; Yadava, R.N., Tripathi, A., Novel flavone glycoside from the stem of Bauhinia purpurea (2000) Fitoterapia, 71, pp. 88-90; Salantino, A., Blatt, T.T., Foliar Flavanoids of nine species of Bauhinia (1999) Revista Brsileira de Botanica, 22, pp. 17-20; Panda, S., Kar, A., Withania Somnifera and Bauhinia purpurea in the regulation of circulating thyroid hormone concentrations in female mice (1999) J Ethnopharmacol, 67, pp. 233-239; Vijayakumari, K.P., Siddhuraru, Chemical composition, amino acid content and quality of protein in the legume of Bauhinia purpurea (1997) J Sci Food Agr, 73, pp. 279-286; Ramachandran, R., Joshi, B.C., Chemical examination of Bauhinia purpurea flowers (1967) Curr Sci, 36, pp. 574-575; Pettit, G.R., Numata, A., Iwamoto, C., Usami, Y., Yamada, T., Ohishi, H., Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea (2006) J Nat Prod, 69, pp. 323-327; Wagner, H., Baldt, S., Zgainski, E.M., Plant drug analysis. Springer Verlag (1984), pp. 126-169. , Berlin/ New York:, 291-305; Harborne, J.B., (1973) Phytochemical methods, pp. 52-105. , London: Chapman and Hall Ltd; Stahl, E., (1969) Thin layer chromatography: A laboratory hand book, pp. 206-258. , Springer International. New York; Turner, R.A., (1965) Screening methods in pharmacology, p. 158. , New York: Academic Press; Kamath, J.V., Rana, A.C., Pharmacological Activities of ethanolic extract of Calotropis procera roots (2003) Indian Drugs, 40, pp. 292-295; Sondhi SM, Nidhi Singhal, Verma RP. Synthesis, antiinflammatory and analgesic activity evaluation of some 2-(9-acridinylamino) pyridines and 2-(9-acridinyl amino/ imino) thiazolines. Indian J Chem Br 1997;36:620-4; Vane, J.R., Inhibition of Prostaglandin synthesis as a mechanism of action of Aspirin like durgs (1971) Nat New Biol, 231, p. 232; Winter, C.A., Risely, E.A., Nuss, G.W., Carragenan induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs (1962) Proc Soc Exp Bio Med, 111, pp. 544-547; Vinegar, R., Trauz, J.F., Selph, J.L., Concurrent evaluation and resolution in an acute inflammatory model of rat carrageenan-induced pleurisy (1973) Proc Soc Exp Biol Med, 143, pp. 711-714; Rajnarayana, K., Sripal reddy, M., Chaluvadi, M.R., Krishna, D.R., Preliminary studies on the anti-inflammatory effects of Swertia chirata in albino rats (1995) Indian J Pharmacol, 27, pp. 37-39

PY - 2009

Y1 - 2009

N2 - Objectives: Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models. Materials and Methods: Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy′s hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50mg/kg and 100mg/kg. Results: The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P <0.001). The maximum analgesic effect was observed at 120 min at the dose of 100mg/kg (i.p.) and was comparable to that of standard analgin (150mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50mg/kg and 100mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5mg/kg). Conclusion: Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.

AB - Objectives: Ethanol extract of the stem of Bauhinia purpurea Linn. was subjected to analgesic and anti-inflammatory activities in animal models. Materials and Methods: Albino Wistar rats and mice were the experimental animals respectively. Different CNS depressant paradigms like analgesic activity (determined by Eddy′s hot plate method and acetic acid writhing method) and anti-inflammatory activity determined by carrageenan induced paw edema using plethysmometer in albino rats) were carried out, following the intra-peritoneal administration of ethanol extract of Bauhinia purpurea Linn. (BP) at the dose level of 50mg/kg and 100mg/kg. Results: The analgesic and anti-inflammatory activities of ethanol extracts of BP were significant (P <0.001). The maximum analgesic effect was observed at 120 min at the dose of 100mg/kg (i.p.) and was comparable to that of standard analgin (150mg/kg) and the percentage of edema inhibition effect was 46.4% and 77% for 50mg/kg and 100mg/kg (i.p) respectively. Anti-inflammatory activity was compared with standard Diclofenac sodium (5mg/kg). Conclusion: Ethanol extract of Bauhinia purpurea has shown significant analgesic and anti-inflammatory activities at the dose of 100 mg/kg and was comparable with corresponding standard drugs. The activity was attributed to the presence of phytoconstituents in the tested extract.

U2 - 10.4103/0253-7613.51345

DO - 10.4103/0253-7613.51345

M3 - Article

VL - 41

SP - 75

EP - 79

JO - Indian Journal of Pharmacology

JF - Indian Journal of Pharmacology

SN - 0253-7613

IS - 2

ER -