Screening of Momordica dioica for hepatoprotective, antioxidant, and antiinflammatory activities

C.S. Shreedhara, V.P. Vaidya

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The alcoholic extract of Momordica dioica roots significantly reduced CCl4 induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxygen derived free radicals (ODFR) in vitro with 4000 μg/ml ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen (200 mg/kg, p.o.).
Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalNatural Product Sciences
Volume12
Issue number3
Publication statusPublished - 2006

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Momordica
Transaminases
Glutamic Acid
Screening
Anti-Inflammatory Agents
Antioxidants
Oxaloacetic Acid
Carrageenan
Ibuprofen
Serum
Pyruvic Acid
Free Radicals
Alkaline Phosphatase
Rats
Oxygen
Oral Administration
Edema
Enzymes

Cite this

@article{f28e4cbaf7c84b32a0b364cfccacf19f,
title = "Screening of Momordica dioica for hepatoprotective, antioxidant, and antiinflammatory activities",
abstract = "The alcoholic extract of Momordica dioica roots significantly reduced CCl4 induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxygen derived free radicals (ODFR) in vitro with 4000 μg/ml ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen (200 mg/kg, p.o.).",
author = "C.S. Shreedhara and V.P. Vaidya",
note = "Cited By :10 Export Date: 10 November 2017 CODEN: NPSCF Correspondence Address: Shreedhara, C.S.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India; email: cssncp@rediffmail.com Chemicals/CAS: alkaline phosphatase, 9001-78-9; carbon tetrachloride, 56-23-5; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; ibuprofen, 15687-27-1; silymarin, 65666-07-1 References: Bhattacharya, A., Chatterjee, A., Ghosal, S., Bhattacharya, S.K., Effect of bioactive tannoid principles of Emblica officinalis (amla) (1999) Indian J. Exp. Biol., 37, pp. 676-680; Chandra, T., Sadique, J., Soma Sundaram, S., Effect of Eclipta alba on inflammation and liver injury (1987) Fitoterapia, 58 (1), pp. 23-32; Di Carlo, G., Mascolo, N., Izzo, A.A., Capasso, F., Flavonoids; old and new aspects of a class of natural therapeutic drugs (1999) Life Sci., 65, pp. 337-353; Govindarajan, R., Rastogi, S., Vijayakumar, M., Rawat, A.K.S., Shirwaikar, A., Mehrorotra, S., Pushpangadan, P., Studies on the antioxidant activity of Desmodium gangeticum (2003) Biol. Pharm. Bull., 16, pp. 1424-1427; Harborne, J.B., (1973) Phytochemical Methods, pp. 52-105. , Chapman & Hall Ltd., London; Kind, P.R.N., King, E.J., (1980) Methods of Practical Clinical Biochemistry, pp. 23-58. , Heinman, London; Nadkarni, K.M., (1976) Indian Materia Medica, p. 807. , Popular Prakashan, Bombay; Nishigaki, I., Kuttan, R., Oku, H., Ashoori, F., Abe, H., Yagi, K., Supressive effect of curcumin on lipid peroxidation induced in rats by CCl4 or super (60) CO irradiation (1992) J. Clin. Biochem. Nutr., 13, pp. 23-29; Osawa, T., Kuvakishi, S., Namiki, M., (1990) Antimutagenesis and Anticarcinogenesis Mechanisms II, pp. 139-153. , Plenum, New York; Rang, H.P., Dale, M.M., (1987) Text Book of Pharmacology, p. 69. , English language book society, Churchil Livingstone; Reitman, S., Frankel, S., A colorimetric method for the determination of sGOT and sGPT (1957) American J. Clin. Path., 28, pp. 56-63; Sastri, B.N., (1962) The Wealth of India (Raw Materials), p. 408. , CSIR, New Delhi; Satyavathi, G.V., Raina, M.K., Sharma, M., (1987) Medicinal Plants of India Vol. I, p. 317. , ICMR, New Delhi; Satyavathi, G.V., Gupta, A.K., Tandon, N., (1987) Medicinal Plants of India Vol. II, p. 267. , ICMR, New Delhi; Shinmoto, H., Dosako, S., Nakajima, I., Anti-oxidant activity of bovine lactoferrin (1992) Biosci. Biotech. Biochem., 56, pp. 2079-2080; Shreedhara, C.S., Pai, K.S.R., Vaidya, V.P., Postcoital antifertility activity of the root of Momordica dioica Roxb (2001) Indian J. Pharm. Sci., 63 (6), pp. 528-531; Smith, J.H., Ford-Hutchinson, A.W., Elliot, P.N.C., Bolam, J.P., Carrageenin-induced paw oedema in the Rat (1974) J. Pharm. Pharmac., 26, pp. 692-698; Stahl, E., (1969) Thin Layer Chromatography - A Laboratory Hand Book, pp. 206-258. , Springer International, New York; Subramonium, A., Evans, D.A., Rajasekharan, S., Pushpangadan, P., Hepatoprotertive activity of Trichopus zeylanicus (1998) Indian J. Exp. Biol., 36 (4), pp. 385-389; Vaidya, V.P., Shreedhara, C.S., Pai, K.S.R., Analgesic and anticatatonic activity of the root of Momordica dioica Roxb. (2001) Kuvempu Univ. Sci. J., 1 (1), pp. 13-18; Vinegar, R., Trauz, J.F., Selph, J.L., Concurrent evaluation and resolution in an acute inflammatory model of rat rrageenin-induced pleurisy (1973) Proc. Soc. Exp. Biol. Med., 143, pp. 711-714; Wagner, H., Baldt, S., Zgainski, E.M., (1984) Plant Driug Analysis, pp. 126-169. , Springer Verlag, Berlin/New York, and 291-305; Winter, C.A., Risley, E.A., Nuss, G.W., Carrageenan-induced edema in rats (1962) Proc. Soc. Exp. Biol., 111, pp. 544-547",
year = "2006",
language = "English",
volume = "12",
pages = "157--161",
journal = "Natural Product Sciences",
issn = "1226-3907",
publisher = "Korean Society of Pharmacognosy",
number = "3",

}

Screening of Momordica dioica for hepatoprotective, antioxidant, and antiinflammatory activities. / Shreedhara, C.S.; Vaidya, V.P.

In: Natural Product Sciences, Vol. 12, No. 3, 2006, p. 157-161.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Screening of Momordica dioica for hepatoprotective, antioxidant, and antiinflammatory activities

AU - Shreedhara, C.S.

AU - Vaidya, V.P.

N1 - Cited By :10 Export Date: 10 November 2017 CODEN: NPSCF Correspondence Address: Shreedhara, C.S.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal-576 104, India; email: cssncp@rediffmail.com Chemicals/CAS: alkaline phosphatase, 9001-78-9; carbon tetrachloride, 56-23-5; carrageenan, 9000-07-1, 9049-05-2, 9061-82-9, 9064-57-7; ibuprofen, 15687-27-1; silymarin, 65666-07-1 References: Bhattacharya, A., Chatterjee, A., Ghosal, S., Bhattacharya, S.K., Effect of bioactive tannoid principles of Emblica officinalis (amla) (1999) Indian J. Exp. Biol., 37, pp. 676-680; Chandra, T., Sadique, J., Soma Sundaram, S., Effect of Eclipta alba on inflammation and liver injury (1987) Fitoterapia, 58 (1), pp. 23-32; Di Carlo, G., Mascolo, N., Izzo, A.A., Capasso, F., Flavonoids; old and new aspects of a class of natural therapeutic drugs (1999) Life Sci., 65, pp. 337-353; Govindarajan, R., Rastogi, S., Vijayakumar, M., Rawat, A.K.S., Shirwaikar, A., Mehrorotra, S., Pushpangadan, P., Studies on the antioxidant activity of Desmodium gangeticum (2003) Biol. Pharm. Bull., 16, pp. 1424-1427; Harborne, J.B., (1973) Phytochemical Methods, pp. 52-105. , Chapman & Hall Ltd., London; Kind, P.R.N., King, E.J., (1980) Methods of Practical Clinical Biochemistry, pp. 23-58. , Heinman, London; Nadkarni, K.M., (1976) Indian Materia Medica, p. 807. , Popular Prakashan, Bombay; Nishigaki, I., Kuttan, R., Oku, H., Ashoori, F., Abe, H., Yagi, K., Supressive effect of curcumin on lipid peroxidation induced in rats by CCl4 or super (60) CO irradiation (1992) J. Clin. Biochem. Nutr., 13, pp. 23-29; Osawa, T., Kuvakishi, S., Namiki, M., (1990) Antimutagenesis and Anticarcinogenesis Mechanisms II, pp. 139-153. , Plenum, New York; Rang, H.P., Dale, M.M., (1987) Text Book of Pharmacology, p. 69. , English language book society, Churchil Livingstone; Reitman, S., Frankel, S., A colorimetric method for the determination of sGOT and sGPT (1957) American J. Clin. Path., 28, pp. 56-63; Sastri, B.N., (1962) The Wealth of India (Raw Materials), p. 408. , CSIR, New Delhi; Satyavathi, G.V., Raina, M.K., Sharma, M., (1987) Medicinal Plants of India Vol. I, p. 317. , ICMR, New Delhi; Satyavathi, G.V., Gupta, A.K., Tandon, N., (1987) Medicinal Plants of India Vol. II, p. 267. , ICMR, New Delhi; Shinmoto, H., Dosako, S., Nakajima, I., Anti-oxidant activity of bovine lactoferrin (1992) Biosci. Biotech. Biochem., 56, pp. 2079-2080; Shreedhara, C.S., Pai, K.S.R., Vaidya, V.P., Postcoital antifertility activity of the root of Momordica dioica Roxb (2001) Indian J. Pharm. Sci., 63 (6), pp. 528-531; Smith, J.H., Ford-Hutchinson, A.W., Elliot, P.N.C., Bolam, J.P., Carrageenin-induced paw oedema in the Rat (1974) J. Pharm. Pharmac., 26, pp. 692-698; Stahl, E., (1969) Thin Layer Chromatography - A Laboratory Hand Book, pp. 206-258. , Springer International, New York; Subramonium, A., Evans, D.A., Rajasekharan, S., Pushpangadan, P., Hepatoprotertive activity of Trichopus zeylanicus (1998) Indian J. Exp. Biol., 36 (4), pp. 385-389; Vaidya, V.P., Shreedhara, C.S., Pai, K.S.R., Analgesic and anticatatonic activity of the root of Momordica dioica Roxb. (2001) Kuvempu Univ. Sci. J., 1 (1), pp. 13-18; Vinegar, R., Trauz, J.F., Selph, J.L., Concurrent evaluation and resolution in an acute inflammatory model of rat rrageenin-induced pleurisy (1973) Proc. Soc. Exp. Biol. Med., 143, pp. 711-714; Wagner, H., Baldt, S., Zgainski, E.M., (1984) Plant Driug Analysis, pp. 126-169. , Springer Verlag, Berlin/New York, and 291-305; Winter, C.A., Risley, E.A., Nuss, G.W., Carrageenan-induced edema in rats (1962) Proc. Soc. Exp. Biol., 111, pp. 544-547

PY - 2006

Y1 - 2006

N2 - The alcoholic extract of Momordica dioica roots significantly reduced CCl4 induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxygen derived free radicals (ODFR) in vitro with 4000 μg/ml ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen (200 mg/kg, p.o.).

AB - The alcoholic extract of Momordica dioica roots significantly reduced CCl4 induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxygen derived free radicals (ODFR) in vitro with 4000 μg/ml ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen (200 mg/kg, p.o.).

M3 - Article

VL - 12

SP - 157

EP - 161

JO - Natural Product Sciences

JF - Natural Product Sciences

SN - 1226-3907

IS - 3

ER -