Screening of Momordica dioica for hepatoprotective, antioxidant, and antiinflammatory activities

C.S. Shreedhara, V.P. Vaidya

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The alcoholic extract of Momordica dioica roots significantly reduced CCl4 induced hepatotoxicity in rats upon oral administration (200 mg/kg), as judged from the serum enzyme levels [serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate transaminases (SGPT), and alkaline phosphatase (ALP)]. These results were comparable with sylimarin (1.25 mg/kg, p.o.). The alcoholic extract inhibited the formation of oxygen derived free radicals (ODFR) in vitro with 4000 μg/ml ascorbic system. The alcoholic extract also significantly reduced carrageenan-induced paw edema when administered orally (200 mg/kg) and the activity was comparable with ibuprofen (200 mg/kg, p.o.).
Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalNatural Product Sciences
Volume12
Issue number3
Publication statusPublished - 2006

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