Seasonal variations in markers of stress and oxidative stress in rats

Surekha Bhat, Guruprasad Rao, K. Dilip Murthy, P. Gopalakrishna Bhat

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

High ambient temperature has been reported to increase oxidative stress by increasing lipid peroxidation and decreasing antioxidant defence in transition dairy cows. It is also known to cause an increase in plasma cortisol levels in goats, European hedgehog and human volunteers. High levels of glucocorticoids have been reported to decrease blood glutathione and erythrocyte superoxide dismutase activity in rats. Although institutional animal houses in research laboratories of developed countries maintain animals in air-conditioned rooms at constant temperature, the same is not true of animal houses in the developing countries especially those belonging to smaller institutions and this could affect the results of the experiments being conducted on these animals. The present research study was done to assess the effects of seasonal variations on the status of erythrocyte oxidative damage, antioxidant defence and plasma cortisol levels in adult female Wistar rats. Rats were kept in their home cages and were left in non-air-conditioned procedure rooms in two different seasons, Hot season (March-May) and Cool season (June to September). Erythrocyte Thiobarbituric acid reactive substances and plasma cortisol levels were significantly increased in rats exposed to high ambient temperature and humidity of the hot season as compared to the rats of the cool season. Erythrocyte reduced glutathione levels, erythrocyte glutathione peroxidase and superoxide dismutase activities were significantly decreased in the hot season group of rats. The results of our experiments showed that exposure of adult female Wistar rats to high ambient temperature and humidity of the hot season increases neuroendocrine stress, oxidative stress and decreases antioxidant defence in them.

Original languageEnglish
Pages (from-to)191-194
Number of pages4
JournalIndian Journal of Clinical Biochemistry
Volume23
Issue number2
DOIs
Publication statusPublished - 15-09-2008

Fingerprint

Oxidative stress
Rats
Oxidative Stress
Erythrocytes
Animals
Hydrocortisone
Antioxidants
Plasmas
Superoxide Dismutase
Humidity
Glutathione
Atmospheric humidity
Wistar Rats
Hot Temperature
Temperature
Thiobarbituric Acid Reactive Substances
Dairies
Research laboratories
Glutathione Peroxidase
Hedgehogs

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Bhat, Surekha ; Rao, Guruprasad ; Murthy, K. Dilip ; Bhat, P. Gopalakrishna. / Seasonal variations in markers of stress and oxidative stress in rats. In: Indian Journal of Clinical Biochemistry. 2008 ; Vol. 23, No. 2. pp. 191-194.
@article{4e14ad9a0e03492ca574ec27d6863f43,
title = "Seasonal variations in markers of stress and oxidative stress in rats",
abstract = "High ambient temperature has been reported to increase oxidative stress by increasing lipid peroxidation and decreasing antioxidant defence in transition dairy cows. It is also known to cause an increase in plasma cortisol levels in goats, European hedgehog and human volunteers. High levels of glucocorticoids have been reported to decrease blood glutathione and erythrocyte superoxide dismutase activity in rats. Although institutional animal houses in research laboratories of developed countries maintain animals in air-conditioned rooms at constant temperature, the same is not true of animal houses in the developing countries especially those belonging to smaller institutions and this could affect the results of the experiments being conducted on these animals. The present research study was done to assess the effects of seasonal variations on the status of erythrocyte oxidative damage, antioxidant defence and plasma cortisol levels in adult female Wistar rats. Rats were kept in their home cages and were left in non-air-conditioned procedure rooms in two different seasons, Hot season (March-May) and Cool season (June to September). Erythrocyte Thiobarbituric acid reactive substances and plasma cortisol levels were significantly increased in rats exposed to high ambient temperature and humidity of the hot season as compared to the rats of the cool season. Erythrocyte reduced glutathione levels, erythrocyte glutathione peroxidase and superoxide dismutase activities were significantly decreased in the hot season group of rats. The results of our experiments showed that exposure of adult female Wistar rats to high ambient temperature and humidity of the hot season increases neuroendocrine stress, oxidative stress and decreases antioxidant defence in them.",
author = "Surekha Bhat and Guruprasad Rao and Murthy, {K. Dilip} and Bhat, {P. Gopalakrishna}",
year = "2008",
month = "9",
day = "15",
doi = "10.1007/s12291-008-0042-2",
language = "English",
volume = "23",
pages = "191--194",
journal = "Indian Journal of Clinical Biochemistry",
issn = "0970-1915",
publisher = "Springer India",
number = "2",

}

Seasonal variations in markers of stress and oxidative stress in rats. / Bhat, Surekha; Rao, Guruprasad; Murthy, K. Dilip; Bhat, P. Gopalakrishna.

In: Indian Journal of Clinical Biochemistry, Vol. 23, No. 2, 15.09.2008, p. 191-194.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seasonal variations in markers of stress and oxidative stress in rats

AU - Bhat, Surekha

AU - Rao, Guruprasad

AU - Murthy, K. Dilip

AU - Bhat, P. Gopalakrishna

PY - 2008/9/15

Y1 - 2008/9/15

N2 - High ambient temperature has been reported to increase oxidative stress by increasing lipid peroxidation and decreasing antioxidant defence in transition dairy cows. It is also known to cause an increase in plasma cortisol levels in goats, European hedgehog and human volunteers. High levels of glucocorticoids have been reported to decrease blood glutathione and erythrocyte superoxide dismutase activity in rats. Although institutional animal houses in research laboratories of developed countries maintain animals in air-conditioned rooms at constant temperature, the same is not true of animal houses in the developing countries especially those belonging to smaller institutions and this could affect the results of the experiments being conducted on these animals. The present research study was done to assess the effects of seasonal variations on the status of erythrocyte oxidative damage, antioxidant defence and plasma cortisol levels in adult female Wistar rats. Rats were kept in their home cages and were left in non-air-conditioned procedure rooms in two different seasons, Hot season (March-May) and Cool season (June to September). Erythrocyte Thiobarbituric acid reactive substances and plasma cortisol levels were significantly increased in rats exposed to high ambient temperature and humidity of the hot season as compared to the rats of the cool season. Erythrocyte reduced glutathione levels, erythrocyte glutathione peroxidase and superoxide dismutase activities were significantly decreased in the hot season group of rats. The results of our experiments showed that exposure of adult female Wistar rats to high ambient temperature and humidity of the hot season increases neuroendocrine stress, oxidative stress and decreases antioxidant defence in them.

AB - High ambient temperature has been reported to increase oxidative stress by increasing lipid peroxidation and decreasing antioxidant defence in transition dairy cows. It is also known to cause an increase in plasma cortisol levels in goats, European hedgehog and human volunteers. High levels of glucocorticoids have been reported to decrease blood glutathione and erythrocyte superoxide dismutase activity in rats. Although institutional animal houses in research laboratories of developed countries maintain animals in air-conditioned rooms at constant temperature, the same is not true of animal houses in the developing countries especially those belonging to smaller institutions and this could affect the results of the experiments being conducted on these animals. The present research study was done to assess the effects of seasonal variations on the status of erythrocyte oxidative damage, antioxidant defence and plasma cortisol levels in adult female Wistar rats. Rats were kept in their home cages and were left in non-air-conditioned procedure rooms in two different seasons, Hot season (March-May) and Cool season (June to September). Erythrocyte Thiobarbituric acid reactive substances and plasma cortisol levels were significantly increased in rats exposed to high ambient temperature and humidity of the hot season as compared to the rats of the cool season. Erythrocyte reduced glutathione levels, erythrocyte glutathione peroxidase and superoxide dismutase activities were significantly decreased in the hot season group of rats. The results of our experiments showed that exposure of adult female Wistar rats to high ambient temperature and humidity of the hot season increases neuroendocrine stress, oxidative stress and decreases antioxidant defence in them.

UR - http://www.scopus.com/inward/record.url?scp=51349092443&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51349092443&partnerID=8YFLogxK

U2 - 10.1007/s12291-008-0042-2

DO - 10.1007/s12291-008-0042-2

M3 - Article

VL - 23

SP - 191

EP - 194

JO - Indian Journal of Clinical Biochemistry

JF - Indian Journal of Clinical Biochemistry

SN - 0970-1915

IS - 2

ER -