Secreted frizzled related protein 4 (sFRP4) update

A brief review

Neelam M. Pawar, Pragna Rao

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Secreted frizzled-related proteins control a multitude of biological phenomena throughout development and adult life in humans. In parallel, aberrant gene expression and abnormal secreted protein levels accompany a wide range of pathologies in humans. In this review, we provide a brief introduction to sFRP4, an update of the pathways it's involved, its various physiological actions that are reported to contribute to diseases, outlining the importance of its wider research and specific modulation by pharmacologic interventions. First recognized as a novel molecule that co-purified with a disparate protein, its identity was based on its sequence homology to the frizzled receptors. Once multiple members of the family were cloned, their genetic loci, tissue and subcellular distributions were located. Nucleotide and amino acid sequences were characterized and homology to different organisms was found to be present that helped elucidate their actions. Following subsequent experimental studies, they were found to be secreted proteins with an affinity to bind to the Wnt ligands, participating in different developmental and adult homeostatic pathways by the virtue of their regulatory function to the Wnt signal transduction system. Secreted frizzled related protein 4 has garnered considerable attention in the recent years following breakthrough discoveries implicating them in the pathogenesis of various diseases. Studies investigating them can provide information not only regarding their association with a disease but can also help use them as potential biomarkers and therapeutic targets.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalCellular Signalling
Volume45
DOIs
Publication statusPublished - 01-05-2018

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Frizzled Receptors
Biological Phenomena
Proteins
Genetic Loci
Tissue Distribution
Sequence Homology
Amino Acid Sequence
Signal Transduction
Nucleotides
Biomarkers
Pathology
Ligands
Gene Expression
Research
rat Sfrp4 protein
Therapeutics
FRZB protein

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

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Secreted frizzled related protein 4 (sFRP4) update : A brief review. / Pawar, Neelam M.; Rao, Pragna.

In: Cellular Signalling, Vol. 45, 01.05.2018, p. 63-70.

Research output: Contribution to journalReview article

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