Secreted frizzled related proteins: Implications in cancers

Rohit Surana, Sakshi Sikka, Wanpei Cai, Eun Myoung Shin, Sudha R. Warrier, Hong Jie Gabriel Tan, Frank Arfuso, Simon A. Fox, Arun M. Dharmarajan, Alan Prem Kumar

Research output: Contribution to journalReview article

68 Citations (Scopus)

Abstract

The Wnt (wingless-type) signaling pathway plays an important role in embryonic development, tissue homeostasis, and tumor progression becaluse of its effect on cell proliferation, migration, and differentiation. Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or to Frizzled receptors. In recent years, aberrant expression of SFRPs has been reported to be associated with numerous cancers. As gene expression of SFRP members is often lost through promoter hypermethylation, inhibition of methylation through the use of epigenetic modifying agents could renew the expression of SFRP members and further antagonize deleterious Wnt signaling. Several reports have described epigenetic silencing of these Wnt signaling antagonists in various human cancers, suggesting their possible role as tumor suppressors. SFRP family members thus come across as potential tools in combating Wnt-driven tumorigenesis. However, little is known about SFRP family members and their role in different cancers. This review comprehensively covers all the available information on the role of SFRP molecules in various human cancers.

Original languageEnglish
Pages (from-to)53-65
Number of pages13
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1845
Issue number1
DOIs
Publication statusPublished - 12-2013

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research
  • Genetics

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  • Cite this

    Surana, R., Sikka, S., Cai, W., Shin, E. M., Warrier, S. R., Tan, H. J. G., Arfuso, F., Fox, S. A., Dharmarajan, A. M., & Kumar, A. P. (2013). Secreted frizzled related proteins: Implications in cancers. Biochimica et Biophysica Acta - Reviews on Cancer, 1845(1), 53-65. https://doi.org/10.1016/j.bbcan.2013.11.004