Abstract

The aim of the present study was to select the cryoprotective agent for valsartan solid lipidnanoparticles. The cryoprotective agents were mixed with prepared nanoemulsion and lyophilized for 24h. The cryoprotective agent and its concentration were selected on the basis of particle size, polydispersity index and zeta potential. The stability of prepared nanoparticles (with and without cryoprotective agents)was also determined in respect of particle size and polydispersity index. The cryoprotective agents showed their effect in the following order: mannitol > lactose > sorbitol > maltose > glucose > sucrose > PVP > fructose > starch > dextrose. The particle size, PDI and zeta potential of the nanoformulations containing 10 % mannitol was found to be 403 nm, 0.39 and -19.27 mV, respectively. Six months accelerated stabilitystudy data does not show any significant effect (at p > 005) of temperature on the lyophilized nanoformulations.The present study concludes that the mannitol is a very good cryoprotective agent to retain thesmall particle size and least PDI value of valsartan nanoformulations even at temperatures of 30 and 40°C.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalLatin American Journal of Pharmacy
Volume35
Issue number2
Publication statusPublished - 2016

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Valsartan
Cryoprotective Agents
Freeze Drying
Nanoparticles
Lipids
Particle Size
Mannitol
Glucose
Temperature
Maltose
Sorbitol
Lactose
Fructose
Starch
Sucrose

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Drug Discovery

Cite this

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title = "Selection of cryoprotective agent for freeze drying of valsartan solid lipid nanoparticles",
abstract = "The aim of the present study was to select the cryoprotective agent for valsartan solid lipidnanoparticles. The cryoprotective agents were mixed with prepared nanoemulsion and lyophilized for 24h. The cryoprotective agent and its concentration were selected on the basis of particle size, polydispersity index and zeta potential. The stability of prepared nanoparticles (with and without cryoprotective agents)was also determined in respect of particle size and polydispersity index. The cryoprotective agents showed their effect in the following order: mannitol > lactose > sorbitol > maltose > glucose > sucrose > PVP > fructose > starch > dextrose. The particle size, PDI and zeta potential of the nanoformulations containing 10 {\%} mannitol was found to be 403 nm, 0.39 and -19.27 mV, respectively. Six months accelerated stabilitystudy data does not show any significant effect (at p > 005) of temperature on the lyophilized nanoformulations.The present study concludes that the mannitol is a very good cryoprotective agent to retain thesmall particle size and least PDI value of valsartan nanoformulations even at temperatures of 30 and 40°C.",
author = "Lalit Kumar and Reddy, {Meka S.} and Ruchi Verma and Koteshwara, {K. B.}",
year = "2016",
language = "English",
volume = "35",
pages = "284--290",
journal = "Latin American Journal of Pharmacy",
issn = "0326-2383",
publisher = "Colegio de Farmaceuticos de la Provincia de Buenos Aires",
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TY - JOUR

T1 - Selection of cryoprotective agent for freeze drying of valsartan solid lipid nanoparticles

AU - Kumar, Lalit

AU - Reddy, Meka S.

AU - Verma, Ruchi

AU - Koteshwara, K. B.

PY - 2016

Y1 - 2016

N2 - The aim of the present study was to select the cryoprotective agent for valsartan solid lipidnanoparticles. The cryoprotective agents were mixed with prepared nanoemulsion and lyophilized for 24h. The cryoprotective agent and its concentration were selected on the basis of particle size, polydispersity index and zeta potential. The stability of prepared nanoparticles (with and without cryoprotective agents)was also determined in respect of particle size and polydispersity index. The cryoprotective agents showed their effect in the following order: mannitol > lactose > sorbitol > maltose > glucose > sucrose > PVP > fructose > starch > dextrose. The particle size, PDI and zeta potential of the nanoformulations containing 10 % mannitol was found to be 403 nm, 0.39 and -19.27 mV, respectively. Six months accelerated stabilitystudy data does not show any significant effect (at p > 005) of temperature on the lyophilized nanoformulations.The present study concludes that the mannitol is a very good cryoprotective agent to retain thesmall particle size and least PDI value of valsartan nanoformulations even at temperatures of 30 and 40°C.

AB - The aim of the present study was to select the cryoprotective agent for valsartan solid lipidnanoparticles. The cryoprotective agents were mixed with prepared nanoemulsion and lyophilized for 24h. The cryoprotective agent and its concentration were selected on the basis of particle size, polydispersity index and zeta potential. The stability of prepared nanoparticles (with and without cryoprotective agents)was also determined in respect of particle size and polydispersity index. The cryoprotective agents showed their effect in the following order: mannitol > lactose > sorbitol > maltose > glucose > sucrose > PVP > fructose > starch > dextrose. The particle size, PDI and zeta potential of the nanoformulations containing 10 % mannitol was found to be 403 nm, 0.39 and -19.27 mV, respectively. Six months accelerated stabilitystudy data does not show any significant effect (at p > 005) of temperature on the lyophilized nanoformulations.The present study concludes that the mannitol is a very good cryoprotective agent to retain thesmall particle size and least PDI value of valsartan nanoformulations even at temperatures of 30 and 40°C.

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