Self-assembling peptide nanofibrous scaffolds for tissue engineering: Novel approaches and strategies for effective functional regeneration

Manasa Nune, Priyadharshini Kumaraswamy, Uma Maheswari Krishnan, Swaminathan Sethuraman

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Tissue engineering requires an ideal scaffold that will aid in the regeneration of the damaged tissues both structurally and functionally. Conventionally, polymeric nanofibrous scaffolds have been extensively used due to their structural similarity to the native extracellular matrix. Thus far, top-down approaches like electrospinning and phase separation have been predominantly used for the nanofiber fabrication. Recently, self-assembling peptide nanofibers (SAPNF) have been identified as promising scaffolds for tissue engineering applications. Molecular self-assembly of peptides, which is a bottom-up approach has laid foundations for the development of such novel scaffolds. Designer self-assembling peptides provide functional support as well as bio-recognition due to the presence of bioactive motifs embedded in them. However, there are certain limitations to both electrospun and SAPNF scaffolds in terms of synthesis, cues presented to the biological system and applications. Design of composite, hybrid scaffolds by super-positioning possible cues may result in effective functional tissue regeneration at multiple levels.

Original languageEnglish
Pages (from-to)70-84
Number of pages15
JournalCurrent Protein and Peptide Science
Volume14
Issue number1
DOIs
Publication statusPublished - 2013

Fingerprint

Tissue Engineering
Nanofibers
Tissue engineering
Scaffolds
Regeneration
Peptides
Cues
Tissue regeneration
Electrospinning
Biological systems
Scaffolds (biology)
Phase separation
Self assembly
Extracellular Matrix
Tissue
Fabrication
Composite materials

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Nune, Manasa ; Kumaraswamy, Priyadharshini ; Krishnan, Uma Maheswari ; Sethuraman, Swaminathan. / Self-assembling peptide nanofibrous scaffolds for tissue engineering : Novel approaches and strategies for effective functional regeneration. In: Current Protein and Peptide Science. 2013 ; Vol. 14, No. 1. pp. 70-84.
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Self-assembling peptide nanofibrous scaffolds for tissue engineering : Novel approaches and strategies for effective functional regeneration. / Nune, Manasa; Kumaraswamy, Priyadharshini; Krishnan, Uma Maheswari; Sethuraman, Swaminathan.

In: Current Protein and Peptide Science, Vol. 14, No. 1, 2013, p. 70-84.

Research output: Contribution to journalArticle

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