Serial changes in complete blood counts in patients with leptospirosis

Our experience

Deepa Sowkur Anandarama Adiga, Salony Mittal, Harini Venugopal, Sowmya Mittal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Leptospirosis is an infectious disease caused by Leptospira interrogans. It is endemic in many parts of the world. The symptoms vary between milder forms to severe type with organ dysfunction. The disease presents with diagnostic challenge as it clinically mimics acute febrile illness due to other causes. Aim: To study serial changes in complete blood counts in patients with leptospirosis. Materials and Methods: A retrospectively collected data was prospectively studied for clinical and laboratory data of leptospirosis patients proven by raised IgM titres by ELISA on day 2 (Counted from day of admission of patient to hospital) of unexplained fever. The changes in complete blood counts from admission upto the discharge of the patient were studied. SPSS version 13 (SPSS Inc. Chicago) was used for data analysis. The collected data was analysed using frequency, percentage, mean, median, standard deviation and Mann-Whitney test. A p-value less than 0.05 were considered significant. Results: Mean haemoglobin concentration showed a progressive decline (<12.5 gm/dl) from day 1 to day 7 in both mild and severe disease. Platelet counts were significantly low (p=0.002), (<1,50,000 cells/mm3) in severe disease and showed a declining trend as compared to mild disease. Total leukocyte counts were significantly higher (p=0.001), (>11,000 cells/m3) in patients with severe disease from day 4 to day 5 of the illness. Conclusion: Complete blood count is a routine test done in the monitoring of patients with leptospirosis. Declining haemoglobin, marked thrombocytopenia and a normal to high total leukocyte count will help in early detection of severe disease and thus preventing mortality by timely management.

Original languageEnglish
Pages (from-to)EC21-EC24
JournalJournal of Clinical and Diagnostic Research
Volume11
Issue number5
DOIs
Publication statusPublished - 01-05-2017

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Leptospirosis
Blood Cell Count
Blood
Hemoglobins
Fever
Leptospira interrogans
Sick Leave
Patient Discharge
Patient Admission
Physiologic Monitoring
Leukocyte Count
Thrombocytopenia
Communicable Diseases
Immunoglobulin M
Early Diagnosis
Enzyme-Linked Immunosorbent Assay
Mortality
Monitoring

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Adiga, Deepa Sowkur Anandarama ; Mittal, Salony ; Venugopal, Harini ; Mittal, Sowmya. / Serial changes in complete blood counts in patients with leptospirosis : Our experience. In: Journal of Clinical and Diagnostic Research. 2017 ; Vol. 11, No. 5. pp. EC21-EC24.
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Serial changes in complete blood counts in patients with leptospirosis : Our experience. / Adiga, Deepa Sowkur Anandarama; Mittal, Salony; Venugopal, Harini; Mittal, Sowmya.

In: Journal of Clinical and Diagnostic Research, Vol. 11, No. 5, 01.05.2017, p. EC21-EC24.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serial changes in complete blood counts in patients with leptospirosis

T2 - Our experience

AU - Adiga, Deepa Sowkur Anandarama

AU - Mittal, Salony

AU - Venugopal, Harini

AU - Mittal, Sowmya

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Introduction: Leptospirosis is an infectious disease caused by Leptospira interrogans. It is endemic in many parts of the world. The symptoms vary between milder forms to severe type with organ dysfunction. The disease presents with diagnostic challenge as it clinically mimics acute febrile illness due to other causes. Aim: To study serial changes in complete blood counts in patients with leptospirosis. Materials and Methods: A retrospectively collected data was prospectively studied for clinical and laboratory data of leptospirosis patients proven by raised IgM titres by ELISA on day 2 (Counted from day of admission of patient to hospital) of unexplained fever. The changes in complete blood counts from admission upto the discharge of the patient were studied. SPSS version 13 (SPSS Inc. Chicago) was used for data analysis. The collected data was analysed using frequency, percentage, mean, median, standard deviation and Mann-Whitney test. A p-value less than 0.05 were considered significant. Results: Mean haemoglobin concentration showed a progressive decline (<12.5 gm/dl) from day 1 to day 7 in both mild and severe disease. Platelet counts were significantly low (p=0.002), (<1,50,000 cells/mm3) in severe disease and showed a declining trend as compared to mild disease. Total leukocyte counts were significantly higher (p=0.001), (>11,000 cells/m3) in patients with severe disease from day 4 to day 5 of the illness. Conclusion: Complete blood count is a routine test done in the monitoring of patients with leptospirosis. Declining haemoglobin, marked thrombocytopenia and a normal to high total leukocyte count will help in early detection of severe disease and thus preventing mortality by timely management.

AB - Introduction: Leptospirosis is an infectious disease caused by Leptospira interrogans. It is endemic in many parts of the world. The symptoms vary between milder forms to severe type with organ dysfunction. The disease presents with diagnostic challenge as it clinically mimics acute febrile illness due to other causes. Aim: To study serial changes in complete blood counts in patients with leptospirosis. Materials and Methods: A retrospectively collected data was prospectively studied for clinical and laboratory data of leptospirosis patients proven by raised IgM titres by ELISA on day 2 (Counted from day of admission of patient to hospital) of unexplained fever. The changes in complete blood counts from admission upto the discharge of the patient were studied. SPSS version 13 (SPSS Inc. Chicago) was used for data analysis. The collected data was analysed using frequency, percentage, mean, median, standard deviation and Mann-Whitney test. A p-value less than 0.05 were considered significant. Results: Mean haemoglobin concentration showed a progressive decline (<12.5 gm/dl) from day 1 to day 7 in both mild and severe disease. Platelet counts were significantly low (p=0.002), (<1,50,000 cells/mm3) in severe disease and showed a declining trend as compared to mild disease. Total leukocyte counts were significantly higher (p=0.001), (>11,000 cells/m3) in patients with severe disease from day 4 to day 5 of the illness. Conclusion: Complete blood count is a routine test done in the monitoring of patients with leptospirosis. Declining haemoglobin, marked thrombocytopenia and a normal to high total leukocyte count will help in early detection of severe disease and thus preventing mortality by timely management.

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