Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India

Kalwaje Eshwara Vandana, Chiranjay Mukhopadhyay, Chaitanya Tellapragada, Asha Kamath, Meghan Tipre, Vinod Bhat, Nalini Sathiakumar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Although melioidosis, is an important disease in many Southeast Asian countries and Australia, there is limited data on its prevalence and disease burden in India. However, an increase in case reports of melioidosis in recent years indicates its endemicity in India. Aims and methods: A population-based cross-sectional seroprevalence study was undertaken to determine the seroprevalence of B. pseudomallei by indirect haemagglutination assay and to investigate the associated risk determinants. Subjects were 711 adults aged 18 to 65 years residing in Udupi district, located in south-western coast of India. Key results: Overall, 29% of the study subjects were seropositive (titer ≥20). Females were twice as likely to be seropositive compared to males. Rates of seroprevalence were similar in farmers and non-farmers. Besides gardening, other factors including socio-demographic, occupational and environmental factors did not show any relationship with seropositive status. Major conclusions: There is a serological evidence of exposure to B. pseudomallei among adults in India. While the bacterium inhabits soil, exposure to the agent is not limited to farmers. Non-occupational exposure might play an important role in eliciting antibody response to the bacterium and may also be an important factor in disease causation.

Original languageEnglish
Article numbere0004610
JournalPLoS Neglected Tropical Diseases
Volume10
Issue number4
DOIs
Publication statusPublished - 14-04-2016

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Burkholderia pseudomallei
Seroepidemiologic Studies
India
Melioidosis
Gardening
Bacteria
Hemagglutination
Causality
Antibody Formation
Soil
Cross-Sectional Studies
Demography
Population
Farmers

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

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title = "Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India",
abstract = "Background: Although melioidosis, is an important disease in many Southeast Asian countries and Australia, there is limited data on its prevalence and disease burden in India. However, an increase in case reports of melioidosis in recent years indicates its endemicity in India. Aims and methods: A population-based cross-sectional seroprevalence study was undertaken to determine the seroprevalence of B. pseudomallei by indirect haemagglutination assay and to investigate the associated risk determinants. Subjects were 711 adults aged 18 to 65 years residing in Udupi district, located in south-western coast of India. Key results: Overall, 29{\%} of the study subjects were seropositive (titer ≥20). Females were twice as likely to be seropositive compared to males. Rates of seroprevalence were similar in farmers and non-farmers. Besides gardening, other factors including socio-demographic, occupational and environmental factors did not show any relationship with seropositive status. Major conclusions: There is a serological evidence of exposure to B. pseudomallei among adults in India. While the bacterium inhabits soil, exposure to the agent is not limited to farmers. Non-occupational exposure might play an important role in eliciting antibody response to the bacterium and may also be an important factor in disease causation.",
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Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India. / Vandana, Kalwaje Eshwara; Mukhopadhyay, Chiranjay; Tellapragada, Chaitanya; Kamath, Asha; Tipre, Meghan; Bhat, Vinod; Sathiakumar, Nalini.

In: PLoS Neglected Tropical Diseases, Vol. 10, No. 4, e0004610, 14.04.2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Seroprevalence of Burkholderia pseudomallei among Adults in Coastal Areas in Southwestern India

AU - Vandana, Kalwaje Eshwara

AU - Mukhopadhyay, Chiranjay

AU - Tellapragada, Chaitanya

AU - Kamath, Asha

AU - Tipre, Meghan

AU - Bhat, Vinod

AU - Sathiakumar, Nalini

PY - 2016/4/14

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AB - Background: Although melioidosis, is an important disease in many Southeast Asian countries and Australia, there is limited data on its prevalence and disease burden in India. However, an increase in case reports of melioidosis in recent years indicates its endemicity in India. Aims and methods: A population-based cross-sectional seroprevalence study was undertaken to determine the seroprevalence of B. pseudomallei by indirect haemagglutination assay and to investigate the associated risk determinants. Subjects were 711 adults aged 18 to 65 years residing in Udupi district, located in south-western coast of India. Key results: Overall, 29% of the study subjects were seropositive (titer ≥20). Females were twice as likely to be seropositive compared to males. Rates of seroprevalence were similar in farmers and non-farmers. Besides gardening, other factors including socio-demographic, occupational and environmental factors did not show any relationship with seropositive status. Major conclusions: There is a serological evidence of exposure to B. pseudomallei among adults in India. While the bacterium inhabits soil, exposure to the agent is not limited to farmers. Non-occupational exposure might play an important role in eliciting antibody response to the bacterium and may also be an important factor in disease causation.

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