Sertraline-induced hyponatremia

Dhananjay H. Bhat, Harish Thanusubramanian, O. Balaji

Research output: Contribution to journalArticle

Abstract

A 53-year-old female patient with a history of carcinoma of the breast in remission and dilated cardiomyopathy on treatment was newly diagnosed with depression. She was started on sertraline 50 mg once a day. 2 days later she developed severe hyponatremia (serum sodium 114 mEq/l). Her condition further deteriorated and on the 6th day her medication was stopped and replaced with mirtazapine. Osmolality studies she was diagnosed with syndrome of inappropriate antidiuretic hormone secretion. She was treated with IV sodium chloride for her hyponatremia. At discharge serum sodium levels improved (127 mEq/l) and subsequent follow-up 4 weeks later showed normal sodium values (138 mEq/L).

Original languageEnglish
Pages (from-to)1-2
Number of pages2
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume10
Issue number4
DOIs
Publication statusPublished - 01-04-2017
Externally publishedYes

Fingerprint

Sertraline
Hyponatremia
Sodium
Inappropriate ADH Syndrome
Dilated Cardiomyopathy
Serum
Sodium Chloride
Osmolar Concentration
Reference Values
Breast Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Pharmacology (medical)

Cite this

Bhat, Dhananjay H. ; Thanusubramanian, Harish ; Balaji, O. / Sertraline-induced hyponatremia. In: Asian Journal of Pharmaceutical and Clinical Research. 2017 ; Vol. 10, No. 4. pp. 1-2.
@article{b52e4b371f1a4f3197182befb1006c35,
title = "Sertraline-induced hyponatremia",
abstract = "A 53-year-old female patient with a history of carcinoma of the breast in remission and dilated cardiomyopathy on treatment was newly diagnosed with depression. She was started on sertraline 50 mg once a day. 2 days later she developed severe hyponatremia (serum sodium 114 mEq/l). Her condition further deteriorated and on the 6th day her medication was stopped and replaced with mirtazapine. Osmolality studies she was diagnosed with syndrome of inappropriate antidiuretic hormone secretion. She was treated with IV sodium chloride for her hyponatremia. At discharge serum sodium levels improved (127 mEq/l) and subsequent follow-up 4 weeks later showed normal sodium values (138 mEq/L).",
author = "Bhat, {Dhananjay H.} and Harish Thanusubramanian and O. Balaji",
year = "2017",
month = "4",
day = "1",
doi = "10.22159/ajpcr.2017.v10i4.14334",
language = "English",
volume = "10",
pages = "1--2",
journal = "Asian Journal of Pharmaceutical and Clinical Research",
issn = "0974-2441",
publisher = "Innovare Academics Sciences Pvt. Ltd",
number = "4",

}

Sertraline-induced hyponatremia. / Bhat, Dhananjay H.; Thanusubramanian, Harish; Balaji, O.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 10, No. 4, 01.04.2017, p. 1-2.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sertraline-induced hyponatremia

AU - Bhat, Dhananjay H.

AU - Thanusubramanian, Harish

AU - Balaji, O.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - A 53-year-old female patient with a history of carcinoma of the breast in remission and dilated cardiomyopathy on treatment was newly diagnosed with depression. She was started on sertraline 50 mg once a day. 2 days later she developed severe hyponatremia (serum sodium 114 mEq/l). Her condition further deteriorated and on the 6th day her medication was stopped and replaced with mirtazapine. Osmolality studies she was diagnosed with syndrome of inappropriate antidiuretic hormone secretion. She was treated with IV sodium chloride for her hyponatremia. At discharge serum sodium levels improved (127 mEq/l) and subsequent follow-up 4 weeks later showed normal sodium values (138 mEq/L).

AB - A 53-year-old female patient with a history of carcinoma of the breast in remission and dilated cardiomyopathy on treatment was newly diagnosed with depression. She was started on sertraline 50 mg once a day. 2 days later she developed severe hyponatremia (serum sodium 114 mEq/l). Her condition further deteriorated and on the 6th day her medication was stopped and replaced with mirtazapine. Osmolality studies she was diagnosed with syndrome of inappropriate antidiuretic hormone secretion. She was treated with IV sodium chloride for her hyponatremia. At discharge serum sodium levels improved (127 mEq/l) and subsequent follow-up 4 weeks later showed normal sodium values (138 mEq/L).

UR - http://www.scopus.com/inward/record.url?scp=85017145565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017145565&partnerID=8YFLogxK

U2 - 10.22159/ajpcr.2017.v10i4.14334

DO - 10.22159/ajpcr.2017.v10i4.14334

M3 - Article

VL - 10

SP - 1

EP - 2

JO - Asian Journal of Pharmaceutical and Clinical Research

JF - Asian Journal of Pharmaceutical and Clinical Research

SN - 0974-2441

IS - 4

ER -