Abstract
Present study was carried out to compare the levels of serum albumin and glutathione in patients' with brain tumor and healthy controls and to know the relationship between glutathione and serum albumin. The study was carried out in 30 patients with brain tumor and 30 healthy age matched controls. Glutathione levels were measured spectrophotometrically using Beutler's method. Serum albumin and total protein were estimated using automated analyzer and serum globulin was calculated by subtracting albumin from total protein. There was significant decrease in levels of serum albumin, globulin and glutathione (p<0.001) in brain tumor patients compared to healthy controls. On applying Pearson's correlation serum albumin levels correlated positively with glutathione (p<0.01, r = 0.777). Decreased albumin levels reduces the available protein bound thiols, along with decrease in glutathione levels which may further enhances the oxidative stress in patients with brain tumor.
| Original language | English |
|---|---|
| Pages (from-to) | 828-832 |
| Number of pages | 5 |
| Journal | Research Journal of Pharmaceutical, Biological and Chemical Sciences |
| Volume | 2 |
| Issue number | 1 |
| Publication status | Published - 01-01-2011 |
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All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Serum albumin and its relationship with glutathione levels in patients with brain tumor. / Nayal, Bhavna; Manjunath Goud, B. K.; Raghuveer, C. V.; Shetty, Jeevan K.; Devi, Sarsina; Deepa, K.; Devaki, R. N.
In: Research Journal of Pharmaceutical, Biological and Chemical Sciences, Vol. 2, No. 1, 01.01.2011, p. 828-832.Research output: Contribution to journal › Article
TY - JOUR
T1 - Serum albumin and its relationship with glutathione levels in patients with brain tumor
AU - Nayal, Bhavna
AU - Manjunath Goud, B. K.
AU - Raghuveer, C. V.
AU - Shetty, Jeevan K.
AU - Devi, Sarsina
AU - Deepa, K.
AU - Devaki, R. N.
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Present study was carried out to compare the levels of serum albumin and glutathione in patients' with brain tumor and healthy controls and to know the relationship between glutathione and serum albumin. The study was carried out in 30 patients with brain tumor and 30 healthy age matched controls. Glutathione levels were measured spectrophotometrically using Beutler's method. Serum albumin and total protein were estimated using automated analyzer and serum globulin was calculated by subtracting albumin from total protein. There was significant decrease in levels of serum albumin, globulin and glutathione (p<0.001) in brain tumor patients compared to healthy controls. On applying Pearson's correlation serum albumin levels correlated positively with glutathione (p<0.01, r = 0.777). Decreased albumin levels reduces the available protein bound thiols, along with decrease in glutathione levels which may further enhances the oxidative stress in patients with brain tumor.
AB - Present study was carried out to compare the levels of serum albumin and glutathione in patients' with brain tumor and healthy controls and to know the relationship between glutathione and serum albumin. The study was carried out in 30 patients with brain tumor and 30 healthy age matched controls. Glutathione levels were measured spectrophotometrically using Beutler's method. Serum albumin and total protein were estimated using automated analyzer and serum globulin was calculated by subtracting albumin from total protein. There was significant decrease in levels of serum albumin, globulin and glutathione (p<0.001) in brain tumor patients compared to healthy controls. On applying Pearson's correlation serum albumin levels correlated positively with glutathione (p<0.01, r = 0.777). Decreased albumin levels reduces the available protein bound thiols, along with decrease in glutathione levels which may further enhances the oxidative stress in patients with brain tumor.
UR - http://www.scopus.com/inward/record.url?scp=79952145145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952145145&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:79952145145
VL - 2
SP - 828
EP - 832
JO - Research Journal of Pharmaceutical, Biological and Chemical Sciences
JF - Research Journal of Pharmaceutical, Biological and Chemical Sciences
SN - 0975-8585
IS - 1
ER -