Serum albumin and its relationship with glutathione levels in patients with brain tumor

Bhavna Nayal, B. K. Manjunath Goud, C. V. Raghuveer, Jeevan K. Shetty, Sarsina Devi, K. Deepa, R. N. Devaki

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Abstract

Present study was carried out to compare the levels of serum albumin and glutathione in patients' with brain tumor and healthy controls and to know the relationship between glutathione and serum albumin. The study was carried out in 30 patients with brain tumor and 30 healthy age matched controls. Glutathione levels were measured spectrophotometrically using Beutler's method. Serum albumin and total protein were estimated using automated analyzer and serum globulin was calculated by subtracting albumin from total protein. There was significant decrease in levels of serum albumin, globulin and glutathione (p<0.001) in brain tumor patients compared to healthy controls. On applying Pearson's correlation serum albumin levels correlated positively with glutathione (p<0.01, r = 0.777). Decreased albumin levels reduces the available protein bound thiols, along with decrease in glutathione levels which may further enhances the oxidative stress in patients with brain tumor.

Original languageEnglish
Pages (from-to)828-832
Number of pages5
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume2
Issue number1
Publication statusPublished - 01-01-2011

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All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Nayal, B., Manjunath Goud, B. K., Raghuveer, C. V., Shetty, J. K., Devi, S., Deepa, K., & Devaki, R. N. (2011). Serum albumin and its relationship with glutathione levels in patients with brain tumor. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2(1), 828-832.