Alpha-2 macroglobulin and ceruloplasmin are acute phase proteins and are said to regulate the progress of inflammation. Chronic inflammatory states follow severe inflammatory response that is untreated or unchecked. Effect of Phenylbutazone a known inhibitor of eicosanoid response in inflammatory states was studied on these acute phase proteins in cotton pellet granuloma model of inflammation. Serum levels of these acute phase proteins were measured at 24 hours interval from the day of cotton pellet implantation for seven days. The data indicated that Phenylbutazone dose dependently reduced the Alpha-2 macroglobulin and ceruloplasmin during the first 24 hours, which was comparable to that seen in acute carrageenan induced inflammation in rats. However thereafter both acute phase protein increased reaching a peak at 72 hours. The persistent high level of Alpha-2 macroglobulin thereafter and a significant decrease in granuloma formation favors the role of Alpha-2 macroglobulin as a protective protein.
|Number of pages||5|
|Publication status||Published - 01-12-1996|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery