Serum apolipoproteins A and B, lecithin:cholesterol acyl transferase activities and urinary cholesterol levels in nephrotic syndrome patients before and during steroid treatment

S. S. Nayak, N. Bhaskaranand, K. S. Kamath, M. Baliga, A. Venkatesh, A. R. Aroor

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Abstract

Serum apolipoproteins A (Apo-A) and B (Apo-B) and lecithin:cholesterol acyl transferase (LCAT) activities and 24-hour urinary cholesterol levels were estimated in 25 nephrotic children before and during steroid treatment with 4 weeks of daily prednisolone followed by another 4 weeks of alternate-day prednisolone. The patients with untreated nephrotic syndrome (NS) showed significant decrease in serum Apo-A and LCAT activities associated with significant increase in serum Apo-B and urinary cholesterol levels compared to healthy controls (n = 25). Serum Apo-A levels correlated directly and Apo-B levels inversely with the serum albumin concentrations. After a transient elevation, the serum Apo-A level returned to control range by 8 weeks of treatment accompanied by a gradual increase in serum LCAT activity and decrease in urinary cholesterol excretion. Though, the serum Apo-b level was decreased with treatment, it was still significantly high compared to the controls.

Original languageEnglish
Pages (from-to)234-239
Number of pages6
JournalNephron
Volume54
Issue number3
Publication statusPublished - 01-01-1990

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All Science Journal Classification (ASJC) codes

  • Physiology
  • Nephrology
  • Urology
  • Physiology (medical)

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