Serum C peptide level and renal function in diabetes mellitus

M. N. Chowta, P. M. Adhikari, N. K. Chowta, A. K. Shenoy, S. D'Souza

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

C peptide is an active peptide hormone with potentially important physiological effects. C peptide has the capacity to diminish glomerular hyperfiltration and reduce urinary albumin excretion in both experimental and human type 1 diabetes. The present study is aimed at correlating the serum C peptide level with that of renal clearance, urinary albumin excretion and duration of diabetes. This is a prospective cross sectional study. Patients with diagnosis of type 2 diabetes mellitus were evaluated for their baseline clinical and laboratory profile. Both males and females above the age of 18 years were included in the study. The laboratory investigations include fasting serum C peptide, HbA1C , serum creatinine, blood urea nitrogen, urine albumin and creatinine. Creatinine clearance was calculated using modification of diet in renal disease formula from serum creatinine value. A total of 168 patients were included in the study, among them 90 were females (53.57%) and 78 males (46.43%). Mean age of the patients was 57.64 years. Pearson correlation test showed negative correlation of serum C peptide level with creatinine clearance, though statistically not significant. Negative correlation was also seen between serum C peptide, and urine albumin, urine albumin creatinine ratio, HbA1C and duration of diabetes. Mean urine albumin was higher in patients with subnormal C peptide level. Duration of disease was more in patients with lower serum C peptide level. The study has shown weak association of serum C peptide level with microalbuminuria and creatinine clearance. Risk of albuminuria is more in patients with low serum C peptide level.

Original languageEnglish
Pages (from-to)25-28
Number of pages4
JournalIndian Journal of Nephrology
Volume20
Issue number1
DOIs
Publication statusPublished - 01-01-2010

Fingerprint

C-Peptide
Diabetes Mellitus
Kidney
Creatinine
Albumins
Serum
Urine
Diet Therapy
Albuminuria
Peptide Hormones
Blood Urea Nitrogen
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Fasting
Cross-Sectional Studies

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

@article{f913369e070f4922882dd23cde569d02,
title = "Serum C peptide level and renal function in diabetes mellitus",
abstract = "C peptide is an active peptide hormone with potentially important physiological effects. C peptide has the capacity to diminish glomerular hyperfiltration and reduce urinary albumin excretion in both experimental and human type 1 diabetes. The present study is aimed at correlating the serum C peptide level with that of renal clearance, urinary albumin excretion and duration of diabetes. This is a prospective cross sectional study. Patients with diagnosis of type 2 diabetes mellitus were evaluated for their baseline clinical and laboratory profile. Both males and females above the age of 18 years were included in the study. The laboratory investigations include fasting serum C peptide, HbA1C , serum creatinine, blood urea nitrogen, urine albumin and creatinine. Creatinine clearance was calculated using modification of diet in renal disease formula from serum creatinine value. A total of 168 patients were included in the study, among them 90 were females (53.57{\%}) and 78 males (46.43{\%}). Mean age of the patients was 57.64 years. Pearson correlation test showed negative correlation of serum C peptide level with creatinine clearance, though statistically not significant. Negative correlation was also seen between serum C peptide, and urine albumin, urine albumin creatinine ratio, HbA1C and duration of diabetes. Mean urine albumin was higher in patients with subnormal C peptide level. Duration of disease was more in patients with lower serum C peptide level. The study has shown weak association of serum C peptide level with microalbuminuria and creatinine clearance. Risk of albuminuria is more in patients with low serum C peptide level.",
author = "Chowta, {M. N.} and Adhikari, {P. M.} and Chowta, {N. K.} and Shenoy, {A. K.} and S. D'Souza",
year = "2010",
month = "1",
day = "1",
doi = "10.4103/0971-4065.62093",
language = "English",
volume = "20",
pages = "25--28",
journal = "Indian Journal of Nephrology",
issn = "0971-4065",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Serum C peptide level and renal function in diabetes mellitus. / Chowta, M. N.; Adhikari, P. M.; Chowta, N. K.; Shenoy, A. K.; D'Souza, S.

In: Indian Journal of Nephrology, Vol. 20, No. 1, 01.01.2010, p. 25-28.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum C peptide level and renal function in diabetes mellitus

AU - Chowta, M. N.

AU - Adhikari, P. M.

AU - Chowta, N. K.

AU - Shenoy, A. K.

AU - D'Souza, S.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - C peptide is an active peptide hormone with potentially important physiological effects. C peptide has the capacity to diminish glomerular hyperfiltration and reduce urinary albumin excretion in both experimental and human type 1 diabetes. The present study is aimed at correlating the serum C peptide level with that of renal clearance, urinary albumin excretion and duration of diabetes. This is a prospective cross sectional study. Patients with diagnosis of type 2 diabetes mellitus were evaluated for their baseline clinical and laboratory profile. Both males and females above the age of 18 years were included in the study. The laboratory investigations include fasting serum C peptide, HbA1C , serum creatinine, blood urea nitrogen, urine albumin and creatinine. Creatinine clearance was calculated using modification of diet in renal disease formula from serum creatinine value. A total of 168 patients were included in the study, among them 90 were females (53.57%) and 78 males (46.43%). Mean age of the patients was 57.64 years. Pearson correlation test showed negative correlation of serum C peptide level with creatinine clearance, though statistically not significant. Negative correlation was also seen between serum C peptide, and urine albumin, urine albumin creatinine ratio, HbA1C and duration of diabetes. Mean urine albumin was higher in patients with subnormal C peptide level. Duration of disease was more in patients with lower serum C peptide level. The study has shown weak association of serum C peptide level with microalbuminuria and creatinine clearance. Risk of albuminuria is more in patients with low serum C peptide level.

AB - C peptide is an active peptide hormone with potentially important physiological effects. C peptide has the capacity to diminish glomerular hyperfiltration and reduce urinary albumin excretion in both experimental and human type 1 diabetes. The present study is aimed at correlating the serum C peptide level with that of renal clearance, urinary albumin excretion and duration of diabetes. This is a prospective cross sectional study. Patients with diagnosis of type 2 diabetes mellitus were evaluated for their baseline clinical and laboratory profile. Both males and females above the age of 18 years were included in the study. The laboratory investigations include fasting serum C peptide, HbA1C , serum creatinine, blood urea nitrogen, urine albumin and creatinine. Creatinine clearance was calculated using modification of diet in renal disease formula from serum creatinine value. A total of 168 patients were included in the study, among them 90 were females (53.57%) and 78 males (46.43%). Mean age of the patients was 57.64 years. Pearson correlation test showed negative correlation of serum C peptide level with creatinine clearance, though statistically not significant. Negative correlation was also seen between serum C peptide, and urine albumin, urine albumin creatinine ratio, HbA1C and duration of diabetes. Mean urine albumin was higher in patients with subnormal C peptide level. Duration of disease was more in patients with lower serum C peptide level. The study has shown weak association of serum C peptide level with microalbuminuria and creatinine clearance. Risk of albuminuria is more in patients with low serum C peptide level.

UR - http://www.scopus.com/inward/record.url?scp=77953453846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953453846&partnerID=8YFLogxK

U2 - 10.4103/0971-4065.62093

DO - 10.4103/0971-4065.62093

M3 - Article

VL - 20

SP - 25

EP - 28

JO - Indian Journal of Nephrology

JF - Indian Journal of Nephrology

SN - 0971-4065

IS - 1

ER -