Serum copper, ceruloplasmin and thiobarbituric acid reactive substance status in patients with ovarian cancer

Shivananda B. Nayak, Vinutha R. Bhat, Srimathi S. Mayya

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Serum copper, ceruloplasmin and thiobarbituric acid reactive substances (TBARS) were estimated in 30 patients of ovarian cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.01) and ceruloplasmin (P<0.001) levels were significantly increased in ovarian cancer patients as compared to controls. TBARS levels were also found to be highly significant (P<0.001). Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of antioxidants like ceruloplasmin and TBARS along with the trace element like copper may be of value in the early diagnosis of cancer.

Original languageEnglish
Pages (from-to)486-488
Number of pages3
JournalIndian Journal of Physiology and Pharmacology
Volume48
Issue number4
Publication statusPublished - 10-2004

Fingerprint

Ceruloplasmin
Thiobarbituric Acid Reactive Substances
Ovarian Neoplasms
Copper
Trace Elements
Serum
Early Detection of Cancer
Free Radicals
Antioxidants
Neoplasms

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

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abstract = "Serum copper, ceruloplasmin and thiobarbituric acid reactive substances (TBARS) were estimated in 30 patients of ovarian cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.01) and ceruloplasmin (P<0.001) levels were significantly increased in ovarian cancer patients as compared to controls. TBARS levels were also found to be highly significant (P<0.001). Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of antioxidants like ceruloplasmin and TBARS along with the trace element like copper may be of value in the early diagnosis of cancer.",
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AU - Nayak, Shivananda B.

AU - Bhat, Vinutha R.

AU - Mayya, Srimathi S.

PY - 2004/10

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AB - Serum copper, ceruloplasmin and thiobarbituric acid reactive substances (TBARS) were estimated in 30 patients of ovarian cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.01) and ceruloplasmin (P<0.001) levels were significantly increased in ovarian cancer patients as compared to controls. TBARS levels were also found to be highly significant (P<0.001). Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of antioxidants like ceruloplasmin and TBARS along with the trace element like copper may be of value in the early diagnosis of cancer.

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