Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein

Shivananda B. Nayak, S. Yashwanth, Sneha M. Pinto, Vinutha R. Bhat, Srimathi S. Mayya

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalIndian Journal of Physiology and Pharmacology
Volume49
Issue number3
Publication statusPublished - 07-2005

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Ceruloplasmin
Thiobarbituric Acid Reactive Substances
alpha-Fetoproteins
Liver Neoplasms
Sulfhydryl Compounds
Copper
Serum
Proteins
Trace Elements
Early Detection of Cancer
Free Radicals
Neoplasms

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

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abstract = "Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.",
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Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein. / Nayak, Shivananda B.; Yashwanth, S.; Pinto, Sneha M.; Bhat, Vinutha R.; Mayya, Srimathi S.

In: Indian Journal of Physiology and Pharmacology, Vol. 49, No. 3, 07.2005, p. 341-344.

Research output: Contribution to journalArticle

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AU - Mayya, Srimathi S.

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AB - Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.

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