Serum Lactate Dehydrogenase in Non-Hodgkin’s Lymphoma: A Prognostic Indicator

Charu Yadav; Afzal Ahmad; Benedicta D’Souza; Ashish Agarwal; M. Nandini; K. Ashok Prabhu; Vivian D’Souza

doi:10.1007/s12291-015-0511-3

Serum Lactate Dehydrogenase in Non-Hodgkin’s Lymphoma: A Prognostic Indicator

Charu Yadav, Afzal Ahmad, Benedicta D’Souza, Ashish Agarwal, M. Nandini, K. Ashok Prabhu, Vivian D’Souza

Department of Biochemistry, Kasturba Medical College, Mangalore

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Non-Hodgkin’s lymphoma constitutes a group of disorders originating from the malignant transformation of lymphocytes and involving either the lymph nodes or extranodal sites. NHL commonly presents in the sixth to seventh decade of life with a male preponderance (50–75 %). Recent studies have shown importance of serum LDH in prognosis of NHL. Authors report a case of a 63 year old male presenting with complaints of fever and backache for past 4 months. General and systemic examination revealed bilateral axillary lymphadenopathy and splenomegaly respectively. Serum LDH level was highly elevated (3441 U/l). Excisional axillary and bone marrow biopsy were done before oncology referral. Complete workup revealed diffuse Non-Hodgkin’s lymphoma with bone marrow infiltration. Patient died because of acute renal failure due to NHL and DM 2 (Type 2 diabetes mellitus).

Original language	English
Pages (from-to)	240-242
Number of pages	3
Journal	Indian Journal of Clinical Biochemistry
Volume	31
Issue number	2
DOIs	https://doi.org/10.1007/s12291-015-0511-3
Publication status	Published - 01-04-2016

All Science Journal Classification (ASJC) codes

Clinical Biochemistry

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10.1007/s12291-015-0511-3

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title = "Serum Lactate Dehydrogenase in Non-Hodgkin{\textquoteright}s Lymphoma: A Prognostic Indicator",

abstract = "Non-Hodgkin{\textquoteright}s lymphoma constitutes a group of disorders originating from the malignant transformation of lymphocytes and involving either the lymph nodes or extranodal sites. NHL commonly presents in the sixth to seventh decade of life with a male preponderance (50–75 %). Recent studies have shown importance of serum LDH in prognosis of NHL. Authors report a case of a 63 year old male presenting with complaints of fever and backache for past 4 months. General and systemic examination revealed bilateral axillary lymphadenopathy and splenomegaly respectively. Serum LDH level was highly elevated (3441 U/l). Excisional axillary and bone marrow biopsy were done before oncology referral. Complete workup revealed diffuse Non-Hodgkin{\textquoteright}s lymphoma with bone marrow infiltration. Patient died because of acute renal failure due to NHL and DM 2 (Type 2 diabetes mellitus).",

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T1 - Serum Lactate Dehydrogenase in Non-Hodgkin’s Lymphoma

T2 - A Prognostic Indicator

AU - Yadav, Charu

AU - Ahmad, Afzal

AU - D’Souza, Benedicta

AU - Agarwal, Ashish

AU - Nandini, M.

AU - Ashok Prabhu, K.

AU - D’Souza, Vivian

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N2 - Non-Hodgkin’s lymphoma constitutes a group of disorders originating from the malignant transformation of lymphocytes and involving either the lymph nodes or extranodal sites. NHL commonly presents in the sixth to seventh decade of life with a male preponderance (50–75 %). Recent studies have shown importance of serum LDH in prognosis of NHL. Authors report a case of a 63 year old male presenting with complaints of fever and backache for past 4 months. General and systemic examination revealed bilateral axillary lymphadenopathy and splenomegaly respectively. Serum LDH level was highly elevated (3441 U/l). Excisional axillary and bone marrow biopsy were done before oncology referral. Complete workup revealed diffuse Non-Hodgkin’s lymphoma with bone marrow infiltration. Patient died because of acute renal failure due to NHL and DM 2 (Type 2 diabetes mellitus).

AB - Non-Hodgkin’s lymphoma constitutes a group of disorders originating from the malignant transformation of lymphocytes and involving either the lymph nodes or extranodal sites. NHL commonly presents in the sixth to seventh decade of life with a male preponderance (50–75 %). Recent studies have shown importance of serum LDH in prognosis of NHL. Authors report a case of a 63 year old male presenting with complaints of fever and backache for past 4 months. General and systemic examination revealed bilateral axillary lymphadenopathy and splenomegaly respectively. Serum LDH level was highly elevated (3441 U/l). Excisional axillary and bone marrow biopsy were done before oncology referral. Complete workup revealed diffuse Non-Hodgkin’s lymphoma with bone marrow infiltration. Patient died because of acute renal failure due to NHL and DM 2 (Type 2 diabetes mellitus).

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Serum Lactate Dehydrogenase in Non-Hodgkin’s Lymphoma: A Prognostic Indicator

Abstract

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