Serum paraoxonase 1 activity status in patients with liver disorders

Vivekananda Kedage, Manjunatha S. Muttigi, Mahesh S. Shetty, Renuka Suvarna, Soumya S. Rao, Chitralekha Joshi, Mungli Prakash

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background/Aim: Paraoxonase 1 (PON1) is an esterase, exclusively synthesized by liver. The present study has two objectives: to determine the PON1 activity status in various disorders associated with hepatocellular damage and to correlate the changes of PON1 activity with the standard liver function and fasting lipid profile tests in these disorders. Patients and Methods: The study groups consisted of 95 patients with liver diseases including acute viral hepatitis (14), cirrhosis with portal hypertension (33), leptospirosis (14), sepsis and multi organ failure (15), left ventricular failure (9), and falciparum malaria (10); and 53 healthy controls. Serum PON1 activity was measured manually using spectrophotometer. Liver function test parameters and fasting lipid profile were performed in clinical chemistry auto analyzer (Hitachi 912). Results: The serum PON1 activity in patients with acute viral hepatitis and sepsis decreased significantly ( P < 0.001) and moderately in falciparum malaria ( P < 0.05). However, in patients with cirrhosis, leptospirosis and left ventricular patients, its activity did not change significantly. On applying Pearson correlation, serum PON1 activity correlated positively with high-density lipoprotein-cholesterol (HDL-C) in patients with sepsis (r=0.633, P < 0.05), left ventricular failure patients (r=0.814, P < 0.05) and negatively with acute viral hepatitis patients (r=- 0.528, P 0.05). Conclusion: PON1 activity has decreased significantly in acute viral hepatitis, sepsis with multi organ failure and falciparum malaria patients. Determination of PON1 activity may serve as a useful additional test in assessing these conditions.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalSaudi Journal of Gastroenterology
Volume16
Issue number2
DOIs
Publication statusPublished - 01-04-2010
Externally publishedYes

Fingerprint

Aryldialkylphosphatase
Liver
Serum
Hepatitis
Falciparum Malaria
Sepsis
Leptospirosis
Fasting
Fibrosis
Lipids
Clinical Chemistry
Liver Function Tests
Portal Hypertension
Esterases
HDL Cholesterol
Liver Diseases

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Kedage, V., Muttigi, M. S., Shetty, M. S., Suvarna, R., Rao, S. S., Joshi, C., & Prakash, M. (2010). Serum paraoxonase 1 activity status in patients with liver disorders. Saudi Journal of Gastroenterology, 16(2), 79-83. https://doi.org/10.4103/1319-3767.61232
Kedage, Vivekananda ; Muttigi, Manjunatha S. ; Shetty, Mahesh S. ; Suvarna, Renuka ; Rao, Soumya S. ; Joshi, Chitralekha ; Prakash, Mungli. / Serum paraoxonase 1 activity status in patients with liver disorders. In: Saudi Journal of Gastroenterology. 2010 ; Vol. 16, No. 2. pp. 79-83.
@article{9d20d9f836094b0b9287b2112137e8e4,
title = "Serum paraoxonase 1 activity status in patients with liver disorders",
abstract = "Background/Aim: Paraoxonase 1 (PON1) is an esterase, exclusively synthesized by liver. The present study has two objectives: to determine the PON1 activity status in various disorders associated with hepatocellular damage and to correlate the changes of PON1 activity with the standard liver function and fasting lipid profile tests in these disorders. Patients and Methods: The study groups consisted of 95 patients with liver diseases including acute viral hepatitis (14), cirrhosis with portal hypertension (33), leptospirosis (14), sepsis and multi organ failure (15), left ventricular failure (9), and falciparum malaria (10); and 53 healthy controls. Serum PON1 activity was measured manually using spectrophotometer. Liver function test parameters and fasting lipid profile were performed in clinical chemistry auto analyzer (Hitachi 912). Results: The serum PON1 activity in patients with acute viral hepatitis and sepsis decreased significantly ( P < 0.001) and moderately in falciparum malaria ( P < 0.05). However, in patients with cirrhosis, leptospirosis and left ventricular patients, its activity did not change significantly. On applying Pearson correlation, serum PON1 activity correlated positively with high-density lipoprotein-cholesterol (HDL-C) in patients with sepsis (r=0.633, P < 0.05), left ventricular failure patients (r=0.814, P < 0.05) and negatively with acute viral hepatitis patients (r=- 0.528, P 0.05). Conclusion: PON1 activity has decreased significantly in acute viral hepatitis, sepsis with multi organ failure and falciparum malaria patients. Determination of PON1 activity may serve as a useful additional test in assessing these conditions.",
author = "Vivekananda Kedage and Muttigi, {Manjunatha S.} and Shetty, {Mahesh S.} and Renuka Suvarna and Rao, {Soumya S.} and Chitralekha Joshi and Mungli Prakash",
year = "2010",
month = "4",
day = "1",
doi = "10.4103/1319-3767.61232",
language = "English",
volume = "16",
pages = "79--83",
journal = "Saudi Journal of Gastroenterology",
issn = "1319-3767",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "2",

}

Kedage, V, Muttigi, MS, Shetty, MS, Suvarna, R, Rao, SS, Joshi, C & Prakash, M 2010, 'Serum paraoxonase 1 activity status in patients with liver disorders', Saudi Journal of Gastroenterology, vol. 16, no. 2, pp. 79-83. https://doi.org/10.4103/1319-3767.61232

Serum paraoxonase 1 activity status in patients with liver disorders. / Kedage, Vivekananda; Muttigi, Manjunatha S.; Shetty, Mahesh S.; Suvarna, Renuka; Rao, Soumya S.; Joshi, Chitralekha; Prakash, Mungli.

In: Saudi Journal of Gastroenterology, Vol. 16, No. 2, 01.04.2010, p. 79-83.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Serum paraoxonase 1 activity status in patients with liver disorders

AU - Kedage, Vivekananda

AU - Muttigi, Manjunatha S.

AU - Shetty, Mahesh S.

AU - Suvarna, Renuka

AU - Rao, Soumya S.

AU - Joshi, Chitralekha

AU - Prakash, Mungli

PY - 2010/4/1

Y1 - 2010/4/1

N2 - Background/Aim: Paraoxonase 1 (PON1) is an esterase, exclusively synthesized by liver. The present study has two objectives: to determine the PON1 activity status in various disorders associated with hepatocellular damage and to correlate the changes of PON1 activity with the standard liver function and fasting lipid profile tests in these disorders. Patients and Methods: The study groups consisted of 95 patients with liver diseases including acute viral hepatitis (14), cirrhosis with portal hypertension (33), leptospirosis (14), sepsis and multi organ failure (15), left ventricular failure (9), and falciparum malaria (10); and 53 healthy controls. Serum PON1 activity was measured manually using spectrophotometer. Liver function test parameters and fasting lipid profile were performed in clinical chemistry auto analyzer (Hitachi 912). Results: The serum PON1 activity in patients with acute viral hepatitis and sepsis decreased significantly ( P < 0.001) and moderately in falciparum malaria ( P < 0.05). However, in patients with cirrhosis, leptospirosis and left ventricular patients, its activity did not change significantly. On applying Pearson correlation, serum PON1 activity correlated positively with high-density lipoprotein-cholesterol (HDL-C) in patients with sepsis (r=0.633, P < 0.05), left ventricular failure patients (r=0.814, P < 0.05) and negatively with acute viral hepatitis patients (r=- 0.528, P 0.05). Conclusion: PON1 activity has decreased significantly in acute viral hepatitis, sepsis with multi organ failure and falciparum malaria patients. Determination of PON1 activity may serve as a useful additional test in assessing these conditions.

AB - Background/Aim: Paraoxonase 1 (PON1) is an esterase, exclusively synthesized by liver. The present study has two objectives: to determine the PON1 activity status in various disorders associated with hepatocellular damage and to correlate the changes of PON1 activity with the standard liver function and fasting lipid profile tests in these disorders. Patients and Methods: The study groups consisted of 95 patients with liver diseases including acute viral hepatitis (14), cirrhosis with portal hypertension (33), leptospirosis (14), sepsis and multi organ failure (15), left ventricular failure (9), and falciparum malaria (10); and 53 healthy controls. Serum PON1 activity was measured manually using spectrophotometer. Liver function test parameters and fasting lipid profile were performed in clinical chemistry auto analyzer (Hitachi 912). Results: The serum PON1 activity in patients with acute viral hepatitis and sepsis decreased significantly ( P < 0.001) and moderately in falciparum malaria ( P < 0.05). However, in patients with cirrhosis, leptospirosis and left ventricular patients, its activity did not change significantly. On applying Pearson correlation, serum PON1 activity correlated positively with high-density lipoprotein-cholesterol (HDL-C) in patients with sepsis (r=0.633, P < 0.05), left ventricular failure patients (r=0.814, P < 0.05) and negatively with acute viral hepatitis patients (r=- 0.528, P 0.05). Conclusion: PON1 activity has decreased significantly in acute viral hepatitis, sepsis with multi organ failure and falciparum malaria patients. Determination of PON1 activity may serve as a useful additional test in assessing these conditions.

UR - http://www.scopus.com/inward/record.url?scp=77950545921&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950545921&partnerID=8YFLogxK

U2 - 10.4103/1319-3767.61232

DO - 10.4103/1319-3767.61232

M3 - Article

C2 - 20339175

AN - SCOPUS:77950545921

VL - 16

SP - 79

EP - 83

JO - Saudi Journal of Gastroenterology

JF - Saudi Journal of Gastroenterology

SN - 1319-3767

IS - 2

ER -

Kedage V, Muttigi MS, Shetty MS, Suvarna R, Rao SS, Joshi C et al. Serum paraoxonase 1 activity status in patients with liver disorders. Saudi Journal of Gastroenterology. 2010 Apr 1;16(2):79-83. https://doi.org/10.4103/1319-3767.61232