Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: Case of cervical and oral cancers

Gopal Karemore, Sujatha, Lavanya Rai, Keerthilatha M. Pai, V. B. Kartha, C. Santhosh

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Abstract

The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.

Original languageEnglish
Article number71820J
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7182
DOIs
Publication statusPublished - 01-06-2009

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All Science Journal Classification (ASJC) codes

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

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