Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence

Case of cervical and oral cancers

Gopal Karemore, Sujatha, Lavanya Rai, Keerthilatha M. Pai, V. B. Kartha, C. Santhosh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.

Original languageEnglish
Article number71820J
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7182
DOIs
Publication statusPublished - 01-06-2009

Fingerprint

Laser-induced Fluorescence
Mouth Neoplasms
High-performance Liquid Chromatography
liquid chromatography
High performance liquid chromatography
Uterine Cervical Neoplasms
serums
laser induced fluorescence
Blood Proteins
Cancer
Lasers
Fluorescence
cancer
High Pressure Liquid Chromatography
proteins
Proteins
Protein
Cluster Analysis
Fuzzy clustering
profiles

All Science Journal Classification (ASJC) codes

  • Applied Mathematics
  • Computer Science Applications
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

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