Serum total thiol status in alcohol abusers

Mungli Prakash, Jeevan K. Shetty, Sudeshna Tripathy, Manish Verma, Saddinamane Vasudev, Panambur V. Bhandary

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Thiol (-SH) groups are the major intracellular and extracellular reducing agents. This study estimates such thiol groups in alcohol abusers. Serum total thiols and liver function test parameters were estimated by spectrophotometric methods in alcohol abusers on admission (group I) and thirty days after alcohol abstinence along with life style modification (group II) and in non-alcoholic healthy controls. Serum amino transaminases, gamma glutamyl transpeptidase levels were increased and total thiols, total proteins and albumin levels were decreased in group I cases compared to group II cases and controls. Total thiols status improved significantly along with tranasaminases and transapeptidase with thirty days of alcohol abstinence and life style modification. In conclusion, total thiol status is decreased in alcohol abusers and abstinence of alcohol along with life style modification improves thiol antioxidant status and liver function.

Original languageEnglish
Pages (from-to)48-51
Number of pages4
JournalAsian Journal of Biochemistry
Issue number1
Publication statusPublished - 01-01-2008
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Biochemistry, medical

Cite this

Prakash, M., Shetty, J. K., Tripathy, S., Verma, M., Vasudev, S., & Bhandary, P. V. (2008). Serum total thiol status in alcohol abusers. Asian Journal of Biochemistry, 3(1), 48-51.