Sexual ambiguity: Clinical and cytogenetic evaluation of 105 cases

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Abstract

We have studied 105 subjects with sexual ambiguity who attended the Institute of Genetics, Osmania University, Hyderabad, India. They were investigated for chromosomal constitutions and clinical profiles. The correlative results significantly contributed to the classification of these subjects into male pseudohermaphroditism (60.95%), female pseudohermaphroditism (20.95%), true hermaphroditism (13.33%) and mixed gonadal dysgenesis (4.77%). The results also confirm the significant contribution of chromosome abnormalities (18.09%) and hormonal imbalances in the genesis of abnormal sexual development. A thorough understanding of genetic, endocrinological and molecular mechanisms is necessary in the management of children with sexual ambiguity.

Original languageEnglish
Pages (from-to)205-207
Number of pages3
JournalMedical Science Research
Volume27
Issue number3
Publication statusPublished - 1999

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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