Sexual ambiguity

Clinical and cytogenetic evaluation of 105 cases

M. Rajasekhar

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Abstract

    We have studied 105 subjects with sexual ambiguity who attended the Institute of Genetics, Osmania University, Hyderabad, India. They were investigated for chromosomal constitutions and clinical profiles. The correlative results significantly contributed to the classification of these subjects into male pseudohermaphroditism (60.95%), female pseudohermaphroditism (20.95%), true hermaphroditism (13.33%) and mixed gonadal dysgenesis (4.77%). The results also confirm the significant contribution of chromosome abnormalities (18.09%) and hormonal imbalances in the genesis of abnormal sexual development. A thorough understanding of genetic, endocrinological and molecular mechanisms is necessary in the management of children with sexual ambiguity.

    Original languageEnglish
    Pages (from-to)205-207
    Number of pages3
    JournalMedical Science Research
    Volume27
    Issue number3
    Publication statusPublished - 1999

    Fingerprint

    Mixed Gonadal Dysgenesis
    XX Disorders of Sex Development 46
    Ovotesticular Disorders of Sex Development
    XY Disorders of Sex Development 46
    Sexual Development
    Constitution and Bylaws
    Chromosomes
    Cytogenetics
    Chromosome Aberrations
    Molecular Biology
    India
    Genetics

    All Science Journal Classification (ASJC) codes

    • Medicine(all)
    • Biochemistry, Genetics and Molecular Biology(all)

    Cite this

    @article{9102dabef9ba466e97200accb67e9b8c,
    title = "Sexual ambiguity: Clinical and cytogenetic evaluation of 105 cases",
    abstract = "We have studied 105 subjects with sexual ambiguity who attended the Institute of Genetics, Osmania University, Hyderabad, India. They were investigated for chromosomal constitutions and clinical profiles. The correlative results significantly contributed to the classification of these subjects into male pseudohermaphroditism (60.95{\%}), female pseudohermaphroditism (20.95{\%}), true hermaphroditism (13.33{\%}) and mixed gonadal dysgenesis (4.77{\%}). The results also confirm the significant contribution of chromosome abnormalities (18.09{\%}) and hormonal imbalances in the genesis of abnormal sexual development. A thorough understanding of genetic, endocrinological and molecular mechanisms is necessary in the management of children with sexual ambiguity.",
    author = "M. Rajasekhar",
    year = "1999",
    language = "English",
    volume = "27",
    pages = "205--207",
    journal = "Medical Science Research",
    issn = "0269-8951",
    publisher = "Lippincott Williams and Wilkins",
    number = "3",

    }

    Sexual ambiguity : Clinical and cytogenetic evaluation of 105 cases. / Rajasekhar, M.

    In: Medical Science Research, Vol. 27, No. 3, 1999, p. 205-207.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Sexual ambiguity

    T2 - Clinical and cytogenetic evaluation of 105 cases

    AU - Rajasekhar, M.

    PY - 1999

    Y1 - 1999

    N2 - We have studied 105 subjects with sexual ambiguity who attended the Institute of Genetics, Osmania University, Hyderabad, India. They were investigated for chromosomal constitutions and clinical profiles. The correlative results significantly contributed to the classification of these subjects into male pseudohermaphroditism (60.95%), female pseudohermaphroditism (20.95%), true hermaphroditism (13.33%) and mixed gonadal dysgenesis (4.77%). The results also confirm the significant contribution of chromosome abnormalities (18.09%) and hormonal imbalances in the genesis of abnormal sexual development. A thorough understanding of genetic, endocrinological and molecular mechanisms is necessary in the management of children with sexual ambiguity.

    AB - We have studied 105 subjects with sexual ambiguity who attended the Institute of Genetics, Osmania University, Hyderabad, India. They were investigated for chromosomal constitutions and clinical profiles. The correlative results significantly contributed to the classification of these subjects into male pseudohermaphroditism (60.95%), female pseudohermaphroditism (20.95%), true hermaphroditism (13.33%) and mixed gonadal dysgenesis (4.77%). The results also confirm the significant contribution of chromosome abnormalities (18.09%) and hormonal imbalances in the genesis of abnormal sexual development. A thorough understanding of genetic, endocrinological and molecular mechanisms is necessary in the management of children with sexual ambiguity.

    UR - http://www.scopus.com/inward/record.url?scp=0032775849&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0032775849&partnerID=8YFLogxK

    M3 - Article

    VL - 27

    SP - 205

    EP - 207

    JO - Medical Science Research

    JF - Medical Science Research

    SN - 0269-8951

    IS - 3

    ER -