Short term antidiabetic studies on alcoholic root extract of Pseudarthria viscida Linn.

K. Rajendran, K.G. Sam, K.K. Srinivasan, A. Shirwaikar

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Pseudarthria viscida (L.) Wight and Arnott. (Leguminosae) commonly known as Salaparani and its roots are commonly used by the tribes of Madhya Pradesh. A short study was undertaken as a preliminary investigation to evaluate the antidiabetic effect of the alcoholic root extract by oral glucose tolerance test (OGTT), normoglycemic and antihyperglycemic activity in streptozotocin (STZ)-nicotinamide induced non insulin-dependent diabetes mellitus rats. Graded doses (250 and 500 mg/kg) of the alcoholic root extract suspended in gum acacia were administered to normal and experimental diabetic rats. Effect on glucose tolerance test showed a significant fall in the blood glucose level of extract treated animals after 1 hr, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed till 4 hr of administration in normoglycemic and diabetic rats. The results were compared with standard drug glibenclamide. © Pharmascope Foundation.
Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalInternational Journal of Research in Pharmaceutical Sciences
Volume1
Issue number3
Publication statusPublished - 2010

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