Short term antidiabetic studies on alcoholic root extract of Pseudarthria viscida Linn.

K. Rajendran, K.G. Sam, K.K. Srinivasan, A. Shirwaikar

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Pseudarthria viscida (L.) Wight and Arnott. (Leguminosae) commonly known as Salaparani and its roots are commonly used by the tribes of Madhya Pradesh. A short study was undertaken as a preliminary investigation to evaluate the antidiabetic effect of the alcoholic root extract by oral glucose tolerance test (OGTT), normoglycemic and antihyperglycemic activity in streptozotocin (STZ)-nicotinamide induced non insulin-dependent diabetes mellitus rats. Graded doses (250 and 500 mg/kg) of the alcoholic root extract suspended in gum acacia were administered to normal and experimental diabetic rats. Effect on glucose tolerance test showed a significant fall in the blood glucose level of extract treated animals after 1 hr, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed till 4 hr of administration in normoglycemic and diabetic rats. The results were compared with standard drug glibenclamide. © Pharmascope Foundation.
Original languageEnglish
Pages (from-to)382-385
Number of pages4
JournalInternational Journal of Research in Pharmaceutical Sciences
Volume1
Issue number3
Publication statusPublished - 2010

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Hypoglycemic Agents
Glucose Tolerance Test
Blood Glucose
Gum Arabic
Niacinamide
Glyburide
Streptozocin
Fabaceae
Type 2 Diabetes Mellitus
Pharmaceutical Preparations

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Rajendran, K. ; Sam, K.G. ; Srinivasan, K.K. ; Shirwaikar, A. / Short term antidiabetic studies on alcoholic root extract of Pseudarthria viscida Linn. In: International Journal of Research in Pharmaceutical Sciences. 2010 ; Vol. 1, No. 3. pp. 382-385.
@article{56a12f6a82da435980310cbef8c2729d,
title = "Short term antidiabetic studies on alcoholic root extract of Pseudarthria viscida Linn.",
abstract = "Pseudarthria viscida (L.) Wight and Arnott. (Leguminosae) commonly known as Salaparani and its roots are commonly used by the tribes of Madhya Pradesh. A short study was undertaken as a preliminary investigation to evaluate the antidiabetic effect of the alcoholic root extract by oral glucose tolerance test (OGTT), normoglycemic and antihyperglycemic activity in streptozotocin (STZ)-nicotinamide induced non insulin-dependent diabetes mellitus rats. Graded doses (250 and 500 mg/kg) of the alcoholic root extract suspended in gum acacia were administered to normal and experimental diabetic rats. Effect on glucose tolerance test showed a significant fall in the blood glucose level of extract treated animals after 1 hr, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed till 4 hr of administration in normoglycemic and diabetic rats. The results were compared with standard drug glibenclamide. {\circledC} Pharmascope Foundation.",
author = "K. Rajendran and K.G. Sam and K.K. Srinivasan and A. Shirwaikar",
note = "Cited By :4 Export Date: 10 November 2017 Correspondence Address: Rajendran, K.; Department of Pharmacognosy, College of Pharmacy, Al-Jabal Al-Gharbi University, Al-Zawia, Libyan Arab Jamahiriya; email: rajejesus@gmail.com Chemicals/CAS: alcohol, 64-17-5; glibenclamide, 10238-21-8; glucose, 50-99-7, 84778-64-3; gum arabic, 9000-01-5; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4 References: Akowuah, G.A., Sadikun, A., Mariam, A., Flavonoid identification and hypoglycaemic studies of the butanol fraction from gynura procumbens (2002) Pharm. Biol., 40, pp. 405-410; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Cherian, S., Kumar, R.V., Augusti, K.T., Kidwai, J.R., Antidiabetic effect of a glycoside of pelargonidin isolated from the Bark of Ficus bengalenesis Linn (1992) Ind. J. Biochem. Biophy., 29, pp. 380-382; Harborne, J.B., Methods of extraction and isolation (1988) Phytochemical Methods, pp. 60-66. , Chapman & Hall, London; Humaira-Yousuf-Shaw, L., Tripathi, L., Bhattacharya, S., Antidiabetic plants used by tribals in Madhya Pradesh (2004) Nat. Prod.Rad., 3, pp. 427-428; Kokate, C.K., (1994) Practical Pharmacognosy, p. 111. , 1st ed., Vallabh Prakashan, New Delhi; Latner, A., Clinical biochemistry (1958) Carbohydrate Metabolism:Abnormalities of Post Absorptive Blood Sugar Level, p. 48. , 2nd ed. Philadelphia: WB Saunders Co; Manickam, M., Ramanathan, M., Jahromi, M.A., Chansouria, J.P., Ray, A.B., Antihyperglycaemic activity of phenolics from Pterocarpus marsupium (1997) J. Nat. Prod., 60, pp. 609-610; Marshall, C.J., Specificity of receptor tyrosine kinase signaling transient vs. sustained extra cellular signal-regulating kinase activation (1995) Cell, 80, pp. 179-185; Massiello, P., Broca, P., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, Development of a new model of type II diabetes in adult rats administered with streptozotocin and nicotinamide (1988) Diabetes, 47, pp. 224-229; (2001) Guideline for Testing of Chemicals - Acute Oral Toxicity- Up and Down Procedure. Organisation for Economic Co-operation and Development, , http://www.epa.gov/oppfead/harmo-nyization/docs/E425guideline.pdf, OECD. Available at; Prince, S.M., Menon, V.P., Hypoglycaemic and other related actions of Tinospora cordifolia in alloxan induced diabetic rats (2000) J. Ethnopharm., 70, pp. 9-15; Saifi, A.Q., Shinde, S., Kavishwar, W.K., Gupta, S.R., Some aspects of phytochemistry and hypoglycaemic actions of Pterocarpus marsupium (1971) J. Res. Ind. Medi., 6, pp. 205-207; Sheehan, E.W., Zemaitis, M.A., Slatkin, D.J., Schiff, P.L., A constituent of Pterocarpus marsupium, (-)epicatechin, as a potential antidiabetic agent (1983) J. Nat. Prod., 46, pp. 232-234; Warrier, P.K., Nambiar, V.P.K., Raman Kutty, C., (1996) Indian Medicinal Plants, 4, p. 366. , Orient Longman, Hyderabad, India",
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Short term antidiabetic studies on alcoholic root extract of Pseudarthria viscida Linn. / Rajendran, K.; Sam, K.G.; Srinivasan, K.K.; Shirwaikar, A.

In: International Journal of Research in Pharmaceutical Sciences, Vol. 1, No. 3, 2010, p. 382-385.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Short term antidiabetic studies on alcoholic root extract of Pseudarthria viscida Linn.

AU - Rajendran, K.

AU - Sam, K.G.

AU - Srinivasan, K.K.

AU - Shirwaikar, A.

N1 - Cited By :4 Export Date: 10 November 2017 Correspondence Address: Rajendran, K.; Department of Pharmacognosy, College of Pharmacy, Al-Jabal Al-Gharbi University, Al-Zawia, Libyan Arab Jamahiriya; email: rajejesus@gmail.com Chemicals/CAS: alcohol, 64-17-5; glibenclamide, 10238-21-8; glucose, 50-99-7, 84778-64-3; gum arabic, 9000-01-5; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4 References: Akowuah, G.A., Sadikun, A., Mariam, A., Flavonoid identification and hypoglycaemic studies of the butanol fraction from gynura procumbens (2002) Pharm. Biol., 40, pp. 405-410; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of Langerhans (1988) Diabetes, 37, pp. 616-621; Cherian, S., Kumar, R.V., Augusti, K.T., Kidwai, J.R., Antidiabetic effect of a glycoside of pelargonidin isolated from the Bark of Ficus bengalenesis Linn (1992) Ind. J. Biochem. Biophy., 29, pp. 380-382; Harborne, J.B., Methods of extraction and isolation (1988) Phytochemical Methods, pp. 60-66. , Chapman & Hall, London; Humaira-Yousuf-Shaw, L., Tripathi, L., Bhattacharya, S., Antidiabetic plants used by tribals in Madhya Pradesh (2004) Nat. Prod.Rad., 3, pp. 427-428; Kokate, C.K., (1994) Practical Pharmacognosy, p. 111. , 1st ed., Vallabh Prakashan, New Delhi; Latner, A., Clinical biochemistry (1958) Carbohydrate Metabolism:Abnormalities of Post Absorptive Blood Sugar Level, p. 48. , 2nd ed. Philadelphia: WB Saunders Co; Manickam, M., Ramanathan, M., Jahromi, M.A., Chansouria, J.P., Ray, A.B., Antihyperglycaemic activity of phenolics from Pterocarpus marsupium (1997) J. Nat. Prod., 60, pp. 609-610; Marshall, C.J., Specificity of receptor tyrosine kinase signaling transient vs. sustained extra cellular signal-regulating kinase activation (1995) Cell, 80, pp. 179-185; Massiello, P., Broca, P., Gross, R., Roye, M., Manteghetti, M., Hillaire-Buys, Development of a new model of type II diabetes in adult rats administered with streptozotocin and nicotinamide (1988) Diabetes, 47, pp. 224-229; (2001) Guideline for Testing of Chemicals - Acute Oral Toxicity- Up and Down Procedure. Organisation for Economic Co-operation and Development, , http://www.epa.gov/oppfead/harmo-nyization/docs/E425guideline.pdf, OECD. Available at; Prince, S.M., Menon, V.P., Hypoglycaemic and other related actions of Tinospora cordifolia in alloxan induced diabetic rats (2000) J. Ethnopharm., 70, pp. 9-15; Saifi, A.Q., Shinde, S., Kavishwar, W.K., Gupta, S.R., Some aspects of phytochemistry and hypoglycaemic actions of Pterocarpus marsupium (1971) J. Res. Ind. Medi., 6, pp. 205-207; Sheehan, E.W., Zemaitis, M.A., Slatkin, D.J., Schiff, P.L., A constituent of Pterocarpus marsupium, (-)epicatechin, as a potential antidiabetic agent (1983) J. Nat. Prod., 46, pp. 232-234; Warrier, P.K., Nambiar, V.P.K., Raman Kutty, C., (1996) Indian Medicinal Plants, 4, p. 366. , Orient Longman, Hyderabad, India

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AB - Pseudarthria viscida (L.) Wight and Arnott. (Leguminosae) commonly known as Salaparani and its roots are commonly used by the tribes of Madhya Pradesh. A short study was undertaken as a preliminary investigation to evaluate the antidiabetic effect of the alcoholic root extract by oral glucose tolerance test (OGTT), normoglycemic and antihyperglycemic activity in streptozotocin (STZ)-nicotinamide induced non insulin-dependent diabetes mellitus rats. Graded doses (250 and 500 mg/kg) of the alcoholic root extract suspended in gum acacia were administered to normal and experimental diabetic rats. Effect on glucose tolerance test showed a significant fall in the blood glucose level of extract treated animals after 1 hr, indicating its hypoglycemic activity. Continuous blood glucose lowering activity was observed till 4 hr of administration in normoglycemic and diabetic rats. The results were compared with standard drug glibenclamide. © Pharmascope Foundation.

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JO - International Journal of Research in Pharmaceutical Sciences

JF - International Journal of Research in Pharmaceutical Sciences

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