Signaling pathways promoting epithelial mesenchymal transition in oral submucous fibrosis and oral squamous cell carcinoma

Smitha Sammith Shetty, Mohit Sharma, Felipe Paiva Fonseca, Pradyumna Jayaram, Ankit Singh Tanwar, Shama Prasada Kabekkodu, Satyamoorthy Kapaettu, Raghu Radhakrishnan

Research output: Contribution to journalReview articlepeer-review

Abstract

Epithelial-mesenchymal transition (EMT) is a critical process that occurs during the embryonic development, wound healing, organ fibrosis and the onset of malignancy. Emerging evidence suggests that the EMT is involved in the invasion and metastasis of cancers. The inflammatory reaction antecedent to fibrosis in the onset of oral submucous fibrosis (OSF) and the role of EMT in its malignant transformation indicates a hitherto unexplored involvement of EMT. This review focuses on the role of EMT markers which are regulators of the EMT mediated complex network of molecular mechanisms involved in the pathogenesis of OSF and OSCC. Further the gene enrichment analysis and pathway analysis supports the association of the upregulated and downregulated genes in various EMT regulating pathways.

Original languageEnglish
Pages (from-to)97-108
Number of pages12
JournalJapanese Dental Science Review
Volume56
Issue number1
DOIs
Publication statusPublished - 11-2020

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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