Significance of C-reactive protein during febrile neutropenia in pediatric malignancies

K. Shreedhara Avabratha, A. T.K. Rau, P. Venkataravanamma, Aarathi Rau

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Fifty episodes of febrile neutropenia (FN) in 33 children with malignancies were studied to evaluate the usefulness of C-reactive protein (CRP) levels as an indicator of infection, and the efficacy of antibiotic therapy. Nineteen FN episodes occurred in children with documented infection whereas, 9 and 22 episodes occurred with probable infection and fever of unknown origin, respectively. CRP positivity during episodes of documented and probable infection was significantly higher than with febrile episodes of unknown origin. Blood culture was positive in 15 episodes; of these, CRP was positive in 11. CRP declined to normal on 7th day of antibiotic therapy. CRP is a useful indicator of infection in neutropenic children and also in determining the efficacy of antibiotic therapy.

Original languageEnglish
Pages (from-to)797-799
Number of pages3
JournalIndian Pediatrics
Volume46
Issue number9
Publication statusPublished - 07-10-2009
Externally publishedYes

Fingerprint

Febrile Neutropenia
C-Reactive Protein
Pediatrics
Fever of Unknown Origin
Infection
Neoplasms
Anti-Bacterial Agents
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Avabratha, K. S., Rau, A. T. K., Venkataravanamma, P., & Rau, A. (2009). Significance of C-reactive protein during febrile neutropenia in pediatric malignancies. Indian Pediatrics, 46(9), 797-799.
Avabratha, K. Shreedhara ; Rau, A. T.K. ; Venkataravanamma, P. ; Rau, Aarathi. / Significance of C-reactive protein during febrile neutropenia in pediatric malignancies. In: Indian Pediatrics. 2009 ; Vol. 46, No. 9. pp. 797-799.
@article{4d475de9bdcd42efa6a57cfef90bf950,
title = "Significance of C-reactive protein during febrile neutropenia in pediatric malignancies",
abstract = "Fifty episodes of febrile neutropenia (FN) in 33 children with malignancies were studied to evaluate the usefulness of C-reactive protein (CRP) levels as an indicator of infection, and the efficacy of antibiotic therapy. Nineteen FN episodes occurred in children with documented infection whereas, 9 and 22 episodes occurred with probable infection and fever of unknown origin, respectively. CRP positivity during episodes of documented and probable infection was significantly higher than with febrile episodes of unknown origin. Blood culture was positive in 15 episodes; of these, CRP was positive in 11. CRP declined to normal on 7th day of antibiotic therapy. CRP is a useful indicator of infection in neutropenic children and also in determining the efficacy of antibiotic therapy.",
author = "Avabratha, {K. Shreedhara} and Rau, {A. T.K.} and P. Venkataravanamma and Aarathi Rau",
year = "2009",
month = "10",
day = "7",
language = "English",
volume = "46",
pages = "797--799",
journal = "Indian Pediatrics",
issn = "0019-6061",
publisher = "Springer India",
number = "9",

}

Avabratha, KS, Rau, ATK, Venkataravanamma, P & Rau, A 2009, 'Significance of C-reactive protein during febrile neutropenia in pediatric malignancies', Indian Pediatrics, vol. 46, no. 9, pp. 797-799.

Significance of C-reactive protein during febrile neutropenia in pediatric malignancies. / Avabratha, K. Shreedhara; Rau, A. T.K.; Venkataravanamma, P.; Rau, Aarathi.

In: Indian Pediatrics, Vol. 46, No. 9, 07.10.2009, p. 797-799.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Significance of C-reactive protein during febrile neutropenia in pediatric malignancies

AU - Avabratha, K. Shreedhara

AU - Rau, A. T.K.

AU - Venkataravanamma, P.

AU - Rau, Aarathi

PY - 2009/10/7

Y1 - 2009/10/7

N2 - Fifty episodes of febrile neutropenia (FN) in 33 children with malignancies were studied to evaluate the usefulness of C-reactive protein (CRP) levels as an indicator of infection, and the efficacy of antibiotic therapy. Nineteen FN episodes occurred in children with documented infection whereas, 9 and 22 episodes occurred with probable infection and fever of unknown origin, respectively. CRP positivity during episodes of documented and probable infection was significantly higher than with febrile episodes of unknown origin. Blood culture was positive in 15 episodes; of these, CRP was positive in 11. CRP declined to normal on 7th day of antibiotic therapy. CRP is a useful indicator of infection in neutropenic children and also in determining the efficacy of antibiotic therapy.

AB - Fifty episodes of febrile neutropenia (FN) in 33 children with malignancies were studied to evaluate the usefulness of C-reactive protein (CRP) levels as an indicator of infection, and the efficacy of antibiotic therapy. Nineteen FN episodes occurred in children with documented infection whereas, 9 and 22 episodes occurred with probable infection and fever of unknown origin, respectively. CRP positivity during episodes of documented and probable infection was significantly higher than with febrile episodes of unknown origin. Blood culture was positive in 15 episodes; of these, CRP was positive in 11. CRP declined to normal on 7th day of antibiotic therapy. CRP is a useful indicator of infection in neutropenic children and also in determining the efficacy of antibiotic therapy.

UR - http://www.scopus.com/inward/record.url?scp=70349588316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349588316&partnerID=8YFLogxK

M3 - Article

VL - 46

SP - 797

EP - 799

JO - Indian Pediatrics

JF - Indian Pediatrics

SN - 0019-6061

IS - 9

ER -

Avabratha KS, Rau ATK, Venkataravanamma P, Rau A. Significance of C-reactive protein during febrile neutropenia in pediatric malignancies. Indian Pediatrics. 2009 Oct 7;46(9):797-799.