Significance of lymphocytic sister chromatid exchange frequencies in ovarian cancer patients

Pawan Kumar Dhar, Sulochna Devi, T. Ramesh Rao, Usha Kumari, Anita Joseph, M. R. Kumar, Satish Nayak, Y. Shreemati, S. M. Bhat, K. R. Bhat

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Abstract

Very few studies report the analysis of sister chromatid exchanges in ovarian cancer patients. We tested the null hypothesis that SCE frequency increases with the advancing stages of ovarian cancer and follows a Poisson distribution. As controls we examined age- and sex-matched healthy volunteers who had no such past history. An increased average SCE frequency was observed in ovarian cancer patients (6.34 ± 0.09) vis-a-vis controls (4.47 ± 0.12). Further, the data also suggested a stage-wise increase in the SCE frequency.

Original languageEnglish
Pages (from-to)105-108
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume89
Issue number2
DOIs
Publication statusPublished - 15-07-1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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    Kumar Dhar, P., Devi, S., Ramesh Rao, T., Kumari, U., Joseph, A., Kumar, M. R., Nayak, S., Shreemati, Y., Bhat, S. M., & Bhat, K. R. (1996). Significance of lymphocytic sister chromatid exchange frequencies in ovarian cancer patients. Cancer Genetics and Cytogenetics, 89(2), 105-108. https://doi.org/10.1016/0165-4608(95)00071-2