Significance of platelet volume indices in stemi patients: An casecontrol study

Sravan K. Reddy, Ranjan Shetty, Srujitha Marupuru, Nishanth Yedavalli, Kiran Shetty

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. Materials and Methods: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria. In total, 364 patients were included, 173 patients with STEMI, from those patients admitted to the intensive care unit and the emergency ward. In addition, 191 healthy non diabetic non hypertensive agematched controls were enrolled. Results: The Mean age of cases was 59.4±11.9 years and of controls were 55.25±8.5 years. Males (74.6%) had higher incidence of STEMI then females (25.4%). The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.2±2.8) as compared to controls (8.5±6.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.05). According to Pearson correlation analysis, the positive relationship determined between MPV and Gensini score was statistically significant (p < 0.001, r = 0.132). Conclusion: High MPV and PDW seem to be an independent risk factor for STEMI and correlated with the severity of the STEMI. They can be used as a simple, reliable, and economical method for predicting an impending acute coronary event.

Original languageEnglish
Pages (from-to)LC05-LC07
JournalJournal of Clinical and Diagnostic Research
Volume11
Issue number4
DOIs
Publication statusPublished - 01-04-2017
Externally publishedYes

Fingerprint

Platelets
Blood Platelets
Mean Platelet Volume
Intensive care units
ST Elevation Myocardial Infarction
Platelet Count
Observational Studies
Intensive Care Units
Case-Control Studies
Hospital Emergency Service
Atherosclerosis
Myocardial Infarction
Incidence

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Reddy, Sravan K. ; Shetty, Ranjan ; Marupuru, Srujitha ; Yedavalli, Nishanth ; Shetty, Kiran. / Significance of platelet volume indices in stemi patients : An casecontrol study. In: Journal of Clinical and Diagnostic Research. 2017 ; Vol. 11, No. 4. pp. LC05-LC07.
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abstract = "Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. Materials and Methods: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria. In total, 364 patients were included, 173 patients with STEMI, from those patients admitted to the intensive care unit and the emergency ward. In addition, 191 healthy non diabetic non hypertensive agematched controls were enrolled. Results: The Mean age of cases was 59.4±11.9 years and of controls were 55.25±8.5 years. Males (74.6{\%}) had higher incidence of STEMI then females (25.4{\%}). The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.2±2.8) as compared to controls (8.5±6.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.05). According to Pearson correlation analysis, the positive relationship determined between MPV and Gensini score was statistically significant (p < 0.001, r = 0.132). Conclusion: High MPV and PDW seem to be an independent risk factor for STEMI and correlated with the severity of the STEMI. They can be used as a simple, reliable, and economical method for predicting an impending acute coronary event.",
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Significance of platelet volume indices in stemi patients : An casecontrol study. / Reddy, Sravan K.; Shetty, Ranjan; Marupuru, Srujitha; Yedavalli, Nishanth; Shetty, Kiran.

In: Journal of Clinical and Diagnostic Research, Vol. 11, No. 4, 01.04.2017, p. LC05-LC07.

Research output: Contribution to journalArticle

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T1 - Significance of platelet volume indices in stemi patients

T2 - An casecontrol study

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AU - Shetty, Ranjan

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N2 - Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. Materials and Methods: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria. In total, 364 patients were included, 173 patients with STEMI, from those patients admitted to the intensive care unit and the emergency ward. In addition, 191 healthy non diabetic non hypertensive agematched controls were enrolled. Results: The Mean age of cases was 59.4±11.9 years and of controls were 55.25±8.5 years. Males (74.6%) had higher incidence of STEMI then females (25.4%). The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.2±2.8) as compared to controls (8.5±6.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.05). According to Pearson correlation analysis, the positive relationship determined between MPV and Gensini score was statistically significant (p < 0.001, r = 0.132). Conclusion: High MPV and PDW seem to be an independent risk factor for STEMI and correlated with the severity of the STEMI. They can be used as a simple, reliable, and economical method for predicting an impending acute coronary event.

AB - Introduction: Platelets have been well known contributors in the pathogenesis of cardiovascular disorders such as atherosclerosis and its complications such as acute Myocardial Infarction (MI). Aim: To study the changes in platelet volume indices and platelet count in ST-Elevated Myocardial Infarction (STEMI) and assess their usefulness in predicting coronary events. Materials and Methods: A case-control observational study was carried out on 173 cases diagnosed with STEMI and 191 controls from January 2015 to December 2015, considering the inclusion and exclusion criteria. In total, 364 patients were included, 173 patients with STEMI, from those patients admitted to the intensive care unit and the emergency ward. In addition, 191 healthy non diabetic non hypertensive agematched controls were enrolled. Results: The Mean age of cases was 59.4±11.9 years and of controls were 55.25±8.5 years. Males (74.6%) had higher incidence of STEMI then females (25.4%). The Mean Platelet Volume (MPV) was significantly higher in patients with STEMI (10.2±2.8) as compared to controls (8.5±6.9). The Platelet Distribution Width (PDW) was also significantly higher in cases compared to controls (p<0.05). According to Pearson correlation analysis, the positive relationship determined between MPV and Gensini score was statistically significant (p < 0.001, r = 0.132). Conclusion: High MPV and PDW seem to be an independent risk factor for STEMI and correlated with the severity of the STEMI. They can be used as a simple, reliable, and economical method for predicting an impending acute coronary event.

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