Abstract
It is challenging to maintain normoglycemic range of glucose concentration in type I diabetic patients. In this study H∞ control is applied for insulin delivery to prevent the hyperglycemic levels in a type I diabetic patient. From a control theory point of view, the blood glucose regulation problem is reformulated as a tracking one. A glucose tolerance curve (GTC) validated from several patients is used as reference model. Intra- and inter-patient variability poses a challenging task to control blood glucose concentration in diabetic patients. We develop a data based robust controller to control blood glucose concentration in type I diabetic (TIDM) patients in the presence of meal disturbances under patient-model mismatch. Simulation studies are performed on the diabetic patient model under feedback control. It is seen that the proposed control strategy is able to control blood glucose concentration well within the acceptable limits and also compensate for slow parametric drifts.
| Original language | English |
|---|---|
| Pages (from-to) | 230-235 |
| Number of pages | 6 |
| Journal | IETE Journal of Research |
| Volume | 55 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 09-2009 |
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All Science Journal Classification (ASJC) codes
- Theoretical Computer Science
- Computer Science Applications
- Electrical and Electronic Engineering
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Simulation study on closed loop control algorithm of type 1 diabetes mellitus patients. / Kamath, Surekha; George, V. I.; Vidyasagar, Sudha.
In: IETE Journal of Research, Vol. 55, No. 5, 09.2009, p. 230-235.Research output: Contribution to journal › Article
TY - JOUR
T1 - Simulation study on closed loop control algorithm of type 1 diabetes mellitus patients
AU - Kamath, Surekha
AU - George, V. I.
AU - Vidyasagar, Sudha
PY - 2009/9
Y1 - 2009/9
N2 - It is challenging to maintain normoglycemic range of glucose concentration in type I diabetic patients. In this study H∞ control is applied for insulin delivery to prevent the hyperglycemic levels in a type I diabetic patient. From a control theory point of view, the blood glucose regulation problem is reformulated as a tracking one. A glucose tolerance curve (GTC) validated from several patients is used as reference model. Intra- and inter-patient variability poses a challenging task to control blood glucose concentration in diabetic patients. We develop a data based robust controller to control blood glucose concentration in type I diabetic (TIDM) patients in the presence of meal disturbances under patient-model mismatch. Simulation studies are performed on the diabetic patient model under feedback control. It is seen that the proposed control strategy is able to control blood glucose concentration well within the acceptable limits and also compensate for slow parametric drifts.
AB - It is challenging to maintain normoglycemic range of glucose concentration in type I diabetic patients. In this study H∞ control is applied for insulin delivery to prevent the hyperglycemic levels in a type I diabetic patient. From a control theory point of view, the blood glucose regulation problem is reformulated as a tracking one. A glucose tolerance curve (GTC) validated from several patients is used as reference model. Intra- and inter-patient variability poses a challenging task to control blood glucose concentration in diabetic patients. We develop a data based robust controller to control blood glucose concentration in type I diabetic (TIDM) patients in the presence of meal disturbances under patient-model mismatch. Simulation studies are performed on the diabetic patient model under feedback control. It is seen that the proposed control strategy is able to control blood glucose concentration well within the acceptable limits and also compensate for slow parametric drifts.
UR - http://www.scopus.com/inward/record.url?scp=70449449683&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70449449683&partnerID=8YFLogxK
U2 - 10.4103/0377-2063.57601
DO - 10.4103/0377-2063.57601
M3 - Article
VL - 55
SP - 230
EP - 235
JO - IETE Journal of Research
JF - IETE Journal of Research
SN - 0377-2063
IS - 5
ER -