Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy

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Abstract

Background There are many studies documenting increased prevalence of periodontal infection in women with preeclampsia. But, very few studies have attempted to establish causal relationship between the two. Objective To Wnd out causal circumstantial evidence by isolating speciWc periodontal pathogens in oral and placental samples. Materials and methods Antenatal periodontal screening and subgingival plaque collection was carried out in ten women with hypertension in pregnancy and ten normotensive controls on their hospital admission at term for cesarean delivery. Placental biopsy was obtained after aseptic placental collection at the time of elective cesarean delivery. Subgingival plaque and placental biopsy were studied for Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia and Aggregatibacter actinomycetemcomitans using quantitative polymerase chain reaction technique. Periodontist and laboratory personnel were unaware of case or control status. Periodontal status was not informed to the obstetrician recruiting the cases and laboratory. Microbiology report was not revealed till end of the study. Results Periodontal pathogens were found to be high in the group with hypertension than the controls. P gingivalis was found in all the samples from subgingival plaque and placenta, irrespective of the periodontal disease status. Conclusion In cases with hypertension, periodontal pathogens are present in higher proportion in subgingival plaque and placenta.

Original languageEnglish
Pages (from-to)613-619
Number of pages7
JournalArchives of Gynecology and Obstetrics
Volume285
Issue number3
DOIs
Publication statusPublished - 03-2012

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Placenta
Hypertension
Pregnancy
Treponema denticola
Prevotella intermedia
Fusobacterium nucleatum
Aggregatibacter actinomycetemcomitans
Laboratory Personnel
Biopsy
Porphyromonas gingivalis
Periodontal Diseases
Pre-Eclampsia
Microbiology
Dentists
Prenatal Diagnosis
Polymerase Chain Reaction
Infection

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Obstetrics and Gynaecology

Cite this

@article{efddaf1d4ec04d8cb8d0f566322a38dd,
title = "Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy",
abstract = "Background There are many studies documenting increased prevalence of periodontal infection in women with preeclampsia. But, very few studies have attempted to establish causal relationship between the two. Objective To Wnd out causal circumstantial evidence by isolating speciWc periodontal pathogens in oral and placental samples. Materials and methods Antenatal periodontal screening and subgingival plaque collection was carried out in ten women with hypertension in pregnancy and ten normotensive controls on their hospital admission at term for cesarean delivery. Placental biopsy was obtained after aseptic placental collection at the time of elective cesarean delivery. Subgingival plaque and placental biopsy were studied for Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia and Aggregatibacter actinomycetemcomitans using quantitative polymerase chain reaction technique. Periodontist and laboratory personnel were unaware of case or control status. Periodontal status was not informed to the obstetrician recruiting the cases and laboratory. Microbiology report was not revealed till end of the study. Results Periodontal pathogens were found to be high in the group with hypertension than the controls. P gingivalis was found in all the samples from subgingival plaque and placenta, irrespective of the periodontal disease status. Conclusion In cases with hypertension, periodontal pathogens are present in higher proportion in subgingival plaque and placenta.",
author = "P. Swati and Betsy Thomas and Vahab, {Saadi Abdul} and Satyamoorthy Kapaettu and Pralhad Kushtagi",
year = "2012",
month = "3",
doi = "10.1007/s00404-011-2012-9",
language = "English",
volume = "285",
pages = "613--619",
journal = "Archives of Gynecology and Obstetrics",
issn = "0932-0067",
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TY - JOUR

T1 - Simultaneous detection of periodontal pathogens in subgingival plaque and placenta of women with hypertension in pregnancy

AU - Swati, P.

AU - Thomas, Betsy

AU - Vahab, Saadi Abdul

AU - Kapaettu, Satyamoorthy

AU - Kushtagi, Pralhad

PY - 2012/3

Y1 - 2012/3

N2 - Background There are many studies documenting increased prevalence of periodontal infection in women with preeclampsia. But, very few studies have attempted to establish causal relationship between the two. Objective To Wnd out causal circumstantial evidence by isolating speciWc periodontal pathogens in oral and placental samples. Materials and methods Antenatal periodontal screening and subgingival plaque collection was carried out in ten women with hypertension in pregnancy and ten normotensive controls on their hospital admission at term for cesarean delivery. Placental biopsy was obtained after aseptic placental collection at the time of elective cesarean delivery. Subgingival plaque and placental biopsy were studied for Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia and Aggregatibacter actinomycetemcomitans using quantitative polymerase chain reaction technique. Periodontist and laboratory personnel were unaware of case or control status. Periodontal status was not informed to the obstetrician recruiting the cases and laboratory. Microbiology report was not revealed till end of the study. Results Periodontal pathogens were found to be high in the group with hypertension than the controls. P gingivalis was found in all the samples from subgingival plaque and placenta, irrespective of the periodontal disease status. Conclusion In cases with hypertension, periodontal pathogens are present in higher proportion in subgingival plaque and placenta.

AB - Background There are many studies documenting increased prevalence of periodontal infection in women with preeclampsia. But, very few studies have attempted to establish causal relationship between the two. Objective To Wnd out causal circumstantial evidence by isolating speciWc periodontal pathogens in oral and placental samples. Materials and methods Antenatal periodontal screening and subgingival plaque collection was carried out in ten women with hypertension in pregnancy and ten normotensive controls on their hospital admission at term for cesarean delivery. Placental biopsy was obtained after aseptic placental collection at the time of elective cesarean delivery. Subgingival plaque and placental biopsy were studied for Porphyromonas gingivalis, Fusobacterium nucleatum, Treponema denticola, Prevotella intermedia and Aggregatibacter actinomycetemcomitans using quantitative polymerase chain reaction technique. Periodontist and laboratory personnel were unaware of case or control status. Periodontal status was not informed to the obstetrician recruiting the cases and laboratory. Microbiology report was not revealed till end of the study. Results Periodontal pathogens were found to be high in the group with hypertension than the controls. P gingivalis was found in all the samples from subgingival plaque and placenta, irrespective of the periodontal disease status. Conclusion In cases with hypertension, periodontal pathogens are present in higher proportion in subgingival plaque and placenta.

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