Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry

K.K. Srinivasan, A. Shirwaikar, A. Joseph, S. Jacob, L.S. Prabu

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.
Original languageEnglish
Pages (from-to)576-579
Number of pages4
JournalIndian Drugs
Volume42
Issue number9
Publication statusPublished - 2005

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Ambroxol
Ultraviolet Spectrophotometry
Albuterol
Dosage Forms
Sulfates
Expectorants
Bronchodilator Agents
Tablets

Cite this

Srinivasan, K.K. ; Shirwaikar, A. ; Joseph, A. ; Jacob, S. ; Prabu, L.S. / Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry. In: Indian Drugs. 2005 ; Vol. 42, No. 9. pp. 576-579.
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abstract = "Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.",
author = "K.K. Srinivasan and A. Shirwaikar and A. Joseph and S. Jacob and L.S. Prabu",
note = "Cited By :3 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Srinivasan, K. K.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Mahe, Manipal, India; email: pansrini@yahoo.co.in References: (1996) The Indian Pharmacopoeia, 2, pp. 670-673; (1995) The United States Pharmacopoeia, 23, pp. 38-40; (1988) The British Pharmacopoeia, 2, p. 1001; Patel, M.R., Pattani, V.J., Colorimetric determination of salbutamol sulphate in pharmaceutical formulatuions (1985) Ind.J.Pharm.Sci, 47, p. 59; Rau, H., Laroor, A.R., Gundurao, P., Flourimetric determination of salbutamol sulphate in dosage forms (1992) Ind.J.Pharm.Sci., 54 (2), pp. 79-81; Qin, Y.-P., Zou, Y.-G., Liang, M.-Z., Wang, J.-X., Huang, Y., Yu, Q., Li, T., Determination of salbutamol in human plasma by reversed-phase HPLC with UV detection (2000) Chinese Pharmaceutical Journal, 35 (7), pp. 475-477; Leroux, A.M., Wium, C.A., Joubert, J.R., Van, J.P.P., High Performance Thin layer Chromatographic technique for the determination of salbutamol serum level in clinical trials (1992) J. of Chromatogr.Biomed.Appl., 119, pp. 306-309; Budavari, S., O'Neil, J.M., Smith, A., Heckelman, E.P., (1989) The Merck Index, p. 62. , 11th edition., Merck and Co.Inc., Whitehouse Station.N.J; Reynolds, J.E.F., Prasad, B.A., (1996) Martindale-The Extra Pharmacopoeia, p. 1084. , 33rd Edn., The Pharmaceutical Press,London; Koundourellis, J.E., Malliou, E.T., Broussali, T.A., High performance liquid chromatographic determination of ambroxol in the presence of different preservatives in pharmaceutical formulations (2000) Journal of Pharmaceutical and Biomedical Analysis, 23 (2-3), pp. 469-475. , DOI 10.1016/S0731-7085(00)00318-6, PII S0731708500003186; Zafer, D., Hasan, B., Nilgun, G.G., Quantitative determination of ambroxol in tablets by derivative UV spectrophotometer method and HPLC (2003) J.Pharm. Biomed. Anal., (31), pp. 867-872; Kuchekar, B.S., Shinde, G.S., Naikawadi, I.T., Todkar, K.J., Kharade, S.V., Spectrophotometric estimation of ambroxol hydrochloride in tablets (2003) Ind. J. Pharm. Sci., pp. 193-195. , April",
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Srinivasan, KK, Shirwaikar, A, Joseph, A, Jacob, S & Prabu, LS 2005, 'Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry', Indian Drugs, vol. 42, no. 9, pp. 576-579.

Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry. / Srinivasan, K.K.; Shirwaikar, A.; Joseph, A.; Jacob, S.; Prabu, L.S.

In: Indian Drugs, Vol. 42, No. 9, 2005, p. 576-579.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry

AU - Srinivasan, K.K.

AU - Shirwaikar, A.

AU - Joseph, A.

AU - Jacob, S.

AU - Prabu, L.S.

N1 - Cited By :3 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Srinivasan, K. K.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Mahe, Manipal, India; email: pansrini@yahoo.co.in References: (1996) The Indian Pharmacopoeia, 2, pp. 670-673; (1995) The United States Pharmacopoeia, 23, pp. 38-40; (1988) The British Pharmacopoeia, 2, p. 1001; Patel, M.R., Pattani, V.J., Colorimetric determination of salbutamol sulphate in pharmaceutical formulatuions (1985) Ind.J.Pharm.Sci, 47, p. 59; Rau, H., Laroor, A.R., Gundurao, P., Flourimetric determination of salbutamol sulphate in dosage forms (1992) Ind.J.Pharm.Sci., 54 (2), pp. 79-81; Qin, Y.-P., Zou, Y.-G., Liang, M.-Z., Wang, J.-X., Huang, Y., Yu, Q., Li, T., Determination of salbutamol in human plasma by reversed-phase HPLC with UV detection (2000) Chinese Pharmaceutical Journal, 35 (7), pp. 475-477; Leroux, A.M., Wium, C.A., Joubert, J.R., Van, J.P.P., High Performance Thin layer Chromatographic technique for the determination of salbutamol serum level in clinical trials (1992) J. of Chromatogr.Biomed.Appl., 119, pp. 306-309; Budavari, S., O'Neil, J.M., Smith, A., Heckelman, E.P., (1989) The Merck Index, p. 62. , 11th edition., Merck and Co.Inc., Whitehouse Station.N.J; Reynolds, J.E.F., Prasad, B.A., (1996) Martindale-The Extra Pharmacopoeia, p. 1084. , 33rd Edn., The Pharmaceutical Press,London; Koundourellis, J.E., Malliou, E.T., Broussali, T.A., High performance liquid chromatographic determination of ambroxol in the presence of different preservatives in pharmaceutical formulations (2000) Journal of Pharmaceutical and Biomedical Analysis, 23 (2-3), pp. 469-475. , DOI 10.1016/S0731-7085(00)00318-6, PII S0731708500003186; Zafer, D., Hasan, B., Nilgun, G.G., Quantitative determination of ambroxol in tablets by derivative UV spectrophotometer method and HPLC (2003) J.Pharm. Biomed. Anal., (31), pp. 867-872; Kuchekar, B.S., Shinde, G.S., Naikawadi, I.T., Todkar, K.J., Kharade, S.V., Spectrophotometric estimation of ambroxol hydrochloride in tablets (2003) Ind. J. Pharm. Sci., pp. 193-195. , April

PY - 2005

Y1 - 2005

N2 - Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.

AB - Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.

M3 - Article

VL - 42

SP - 576

EP - 579

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 9

ER -

Srinivasan KK, Shirwaikar A, Joseph A, Jacob S, Prabu LS. Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry. Indian Drugs. 2005;42(9):576-579.

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