Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry

K.K. Srinivasan, A. Shirwaikar, A. Joseph, S. Jacob, L.S. Prabu

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.
Original languageEnglish
Pages (from-to)576-579
Number of pages4
JournalIndian Drugs
Volume42
Issue number9
Publication statusPublished - 2005

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Ambroxol
Ultraviolet Spectrophotometry
Albuterol
Dosage Forms
Sulfates
Expectorants
Bronchodilator Agents
Tablets

Cite this

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title = "Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry",
abstract = "Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.",
author = "K.K. Srinivasan and A. Shirwaikar and A. Joseph and S. Jacob and L.S. Prabu",
note = "Cited By :3 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Srinivasan, K. K.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Mahe, Manipal, India; email: pansrini@yahoo.co.in References: (1996) The Indian Pharmacopoeia, 2, pp. 670-673; (1995) The United States Pharmacopoeia, 23, pp. 38-40; (1988) The British Pharmacopoeia, 2, p. 1001; Patel, M.R., Pattani, V.J., Colorimetric determination of salbutamol sulphate in pharmaceutical formulatuions (1985) Ind.J.Pharm.Sci, 47, p. 59; Rau, H., Laroor, A.R., Gundurao, P., Flourimetric determination of salbutamol sulphate in dosage forms (1992) Ind.J.Pharm.Sci., 54 (2), pp. 79-81; Qin, Y.-P., Zou, Y.-G., Liang, M.-Z., Wang, J.-X., Huang, Y., Yu, Q., Li, T., Determination of salbutamol in human plasma by reversed-phase HPLC with UV detection (2000) Chinese Pharmaceutical Journal, 35 (7), pp. 475-477; Leroux, A.M., Wium, C.A., Joubert, J.R., Van, J.P.P., High Performance Thin layer Chromatographic technique for the determination of salbutamol serum level in clinical trials (1992) J. of Chromatogr.Biomed.Appl., 119, pp. 306-309; Budavari, S., O'Neil, J.M., Smith, A., Heckelman, E.P., (1989) The Merck Index, p. 62. , 11th edition., Merck and Co.Inc., Whitehouse Station.N.J; Reynolds, J.E.F., Prasad, B.A., (1996) Martindale-The Extra Pharmacopoeia, p. 1084. , 33rd Edn., The Pharmaceutical Press,London; Koundourellis, J.E., Malliou, E.T., Broussali, T.A., High performance liquid chromatographic determination of ambroxol in the presence of different preservatives in pharmaceutical formulations (2000) Journal of Pharmaceutical and Biomedical Analysis, 23 (2-3), pp. 469-475. , DOI 10.1016/S0731-7085(00)00318-6, PII S0731708500003186; Zafer, D., Hasan, B., Nilgun, G.G., Quantitative determination of ambroxol in tablets by derivative UV spectrophotometer method and HPLC (2003) J.Pharm. Biomed. Anal., (31), pp. 867-872; Kuchekar, B.S., Shinde, G.S., Naikawadi, I.T., Todkar, K.J., Kharade, S.V., Spectrophotometric estimation of ambroxol hydrochloride in tablets (2003) Ind. J. Pharm. Sci., pp. 193-195. , April",
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Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry. / Srinivasan, K.K.; Shirwaikar, A.; Joseph, A.; Jacob, S.; Prabu, L.S.

In: Indian Drugs, Vol. 42, No. 9, 2005, p. 576-579.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry

AU - Srinivasan, K.K.

AU - Shirwaikar, A.

AU - Joseph, A.

AU - Jacob, S.

AU - Prabu, L.S.

N1 - Cited By :3 Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Srinivasan, K. K.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Mahe, Manipal, India; email: pansrini@yahoo.co.in References: (1996) The Indian Pharmacopoeia, 2, pp. 670-673; (1995) The United States Pharmacopoeia, 23, pp. 38-40; (1988) The British Pharmacopoeia, 2, p. 1001; Patel, M.R., Pattani, V.J., Colorimetric determination of salbutamol sulphate in pharmaceutical formulatuions (1985) Ind.J.Pharm.Sci, 47, p. 59; Rau, H., Laroor, A.R., Gundurao, P., Flourimetric determination of salbutamol sulphate in dosage forms (1992) Ind.J.Pharm.Sci., 54 (2), pp. 79-81; Qin, Y.-P., Zou, Y.-G., Liang, M.-Z., Wang, J.-X., Huang, Y., Yu, Q., Li, T., Determination of salbutamol in human plasma by reversed-phase HPLC with UV detection (2000) Chinese Pharmaceutical Journal, 35 (7), pp. 475-477; Leroux, A.M., Wium, C.A., Joubert, J.R., Van, J.P.P., High Performance Thin layer Chromatographic technique for the determination of salbutamol serum level in clinical trials (1992) J. of Chromatogr.Biomed.Appl., 119, pp. 306-309; Budavari, S., O'Neil, J.M., Smith, A., Heckelman, E.P., (1989) The Merck Index, p. 62. , 11th edition., Merck and Co.Inc., Whitehouse Station.N.J; Reynolds, J.E.F., Prasad, B.A., (1996) Martindale-The Extra Pharmacopoeia, p. 1084. , 33rd Edn., The Pharmaceutical Press,London; Koundourellis, J.E., Malliou, E.T., Broussali, T.A., High performance liquid chromatographic determination of ambroxol in the presence of different preservatives in pharmaceutical formulations (2000) Journal of Pharmaceutical and Biomedical Analysis, 23 (2-3), pp. 469-475. , DOI 10.1016/S0731-7085(00)00318-6, PII S0731708500003186; Zafer, D., Hasan, B., Nilgun, G.G., Quantitative determination of ambroxol in tablets by derivative UV spectrophotometer method and HPLC (2003) J.Pharm. Biomed. Anal., (31), pp. 867-872; Kuchekar, B.S., Shinde, G.S., Naikawadi, I.T., Todkar, K.J., Kharade, S.V., Spectrophotometric estimation of ambroxol hydrochloride in tablets (2003) Ind. J. Pharm. Sci., pp. 193-195. , April

PY - 2005

Y1 - 2005

N2 - Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.

AB - Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.

M3 - Article

VL - 42

SP - 576

EP - 579

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 9

ER -