Simultaneous estimation for the analysis of salbutamol sulphate and ambroxol hydrochloride in solid dosage forms by ultraviolet spectrophotometry

K.K. Srinivasan, A. Shirwaikar, A. Joseph, S. Jacob, L.S. Prabu

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Abstract

Salbutamol sulphate is a bronchodilator and ambroxol hydrochloride is an expectorant. Simple, precise rapid and selective simultaneous equation and Q-analysis UV spectrophotometric methods have been developed for the simultaneous determination of salbutamol and ambroxol from combined tablet dosage forms. The methods involves solving of simultaneous equation and Q-value analysis based on measurement of absorptivity at 232,244 and 276 nm. Linearity lies between 10-50 mcg/mL for ambroxol and 1-15 mcg/mL for salbutamol.
Original languageEnglish
Pages (from-to)576-579
Number of pages4
JournalIndian Drugs
Volume42
Issue number9
Publication statusPublished - 2005

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