Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method

S. Prabu, A. Shirwaikar, C. Kumar, A. Joseph, R. Kumar

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 μg/ml and 8-30 μg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.
Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number1
DOIs
Publication statusPublished - 2008

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