Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method

S. Prabu, A. Shirwaikar, C. Kumar, A. Joseph, R. Kumar

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 μg/ml and 8-30 μg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.
Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number1
DOIs
Publication statusPublished - 2008

Fingerprint

Esomeprazole
Domperidone
Dosage Forms

Cite this

Prabu, S. ; Shirwaikar, A. ; Kumar, C. ; Joseph, A. ; Kumar, R. / Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method. In: Indian Journal of Pharmaceutical Sciences. 2008 ; Vol. 70, No. 1. pp. 128-131.
@article{de79d0172c484c07a6d80fe5fced289d,
title = "Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method",
abstract = "A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 μg/ml and 8-30 μg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.",
author = "S. Prabu and A. Shirwaikar and C. Kumar and A. Joseph and R. Kumar",
note = "Cited By :25 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: domperidone, 57808-66-9; esomeprazole, 119141-88-7, 202742-32-3, 217087-09-7, 217087-10-0 References: Andersson, T., Hassan-Alin, M., Hasselgren, G., Rohss, K., Weidolf, L., Pharmacokinetic studies with Esomeprazole, the (S)-Isomer of omeprazole (2001) Clinical Pharmacokinetics, 40, pp. 411-426; Scott, L.J., Dunn, C.J., Mallarkey, G., Sharpe, M., Esomeprazole- A review of its use in the management of acid-related disorders (2002) Drugs, 62, pp. 1503-1538; British Pharmacopoeia, 1, London: Her Majesty's Stationary Office; 1993. p. 519; Petersen, K.U., Schmutzler, W., Proton pump inhibitors release of active substance from various preparation (1999) Detsche Apotheker Zeitung, 139, pp. 68-69; Castro, D., Moreno, M.A., Torrado, S., Lastres, J.L., Comparison of derivative spectrophotometric and liquid chromatographic methods for the determination of omeprazole in aqueous solution during stability studies (1999) J Pharm Biomed Anal, 21, pp. 291-298; Ozaltin, N., Kocer, A., Determination of omeprazole in pharmaceuticals by derivative spectroscopy (1997) J Pharm Biomed Anal, 16, pp. 337-342; Dogrukol, A.K., Tunalier, Z., Tuncel, M., TLC densitometric determination of omeprazole in pharmaceutical preparations (1998) Pharmazie, 53, pp. 272-273; Sluggett, G.W., Stong, J.D., Adams, J.H., Zhao, Z., Omeprazole determination using HPLC with coulometric detection (2001) J Pharm Biomed Anal, 25, pp. 357-361; Mathew, M., Gupta, V.D., Bailery, R.E., Stability of omeprazole solutions at various pH values as determined by high performance liquid chromatography (1998) Drug Develop Ind Pharm, 21, pp. 965-971; Ding, L., Yang, J., Yan, H.L., Zhang, Z.X., An, D.K., Determination of omeprazole and its pharmacokinetic in human plasma by an improved HPLC method (1999) Chinese J Pharm Anal, 17, pp. 458-461; Shim, S.H., Bok, S.J., Kwon, K.I., Determination of omeprazole in rat plasma by HPLC with column switching (1994) Arch Pharm Res, 17, pp. 458-461; Zhi, X.J., Hunang, J., Zhang, J.H., Wang, H.T., Zhang, L.L., Determination of omeprazole and its metabolites in plasma by RP-HPLC (1999) Chinese J Pharm, 30, pp. 166-168; Motevalian, M., Saeedi, G., Keyhanfar, F., Tayebi, L., Mahmoudian, M., Simultaneous determination of omeprazole and its metabolites in human plasma by HPLC using solid phase extraction (1999) Pharm Pharmacol Commun, 5, pp. 265-268; Yeung, P.K., Little, R., Jiang, Y.Q., Buckley, S.J., Veldhuyzen, S.J., Zanten, V.N., Simple high performance liquid chromatography assay for simultaneous determination of omeprazole and metronidazole in human plasma and gastric fluid (1998) J Pharm Biomed Anal, 17, pp. 1393-1398; Kobayashi, K., Chiba, K.O., Sohn, D.R., Kato, Y., Ishizaki, T., Simultaneous determination of omeprazole and its metabolites in plasma and urine by reversed phase high performance liquid chromatography with an alkaline resistant polymer coated C18 column (1992) J Chromatogr B, 117, pp. 299-305; Amantea, M.A., Narang, P.K., Improved procedure for quantization of omeprazole and metabolites using reversed phase high performance liquid chromatography (1988) J Chromatogr A, 426, pp. 216-222; Hassan-Alin, M., Andersson, T., Bredberg, E., Rohss, K., Pharmacokinetics of esomeprazole after oral and intravenous administration of single and repeated doses to healthy subjects (2000) Eur J Clin Pharmacol, pp. 56-61,665-670; Johnson, D.A., Roach, A.C., Carlsson, A.S., Karlsson, A.A., Behr, D.E., Stability of esomeprazole capsule contents after in vitro suspension in common soft foods and beverages (2003) Pharmacotherapy, 23, pp. 731-734; Li, X.Q., Anderson, T.B., Ahlstrom, M., Weidolf, L., (2004) Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities Drug Metab Dispos, 32, pp. 821-827; Shetty, R., Subramanian, G., Ranjith Kumar, A., Pandey, S., Udupa, N., Estimation of esomeprazole in human plasma by reverse phase high performance liquid chromatography (2005) Indian Drugs, 42, pp. 158-161; Al Khamis, K.L., Hagga, M.E., Al-Khamis, H.A., Spectrophotometric determination of domperidone using absorbance difference method (1990) Anal Lett, 23, pp. 451-460; Ramamohan, Y., Avadhanulu, A.B., Extractive spectrophotometric determination of domperidone in its pharmaceutical dosage forms (1998) Indian Drugs, 35, pp. 754-756; Yamamoto, K., Hagino, M., Kotaki, H., Iga, I., Quantitative determination of domperidone in rat plasma by high performance liquid chromatography with fluorescence detection (1998) J Chromatogr B Biomed Appl, 720, pp. 252-255; Argekar, A.P., Shah, S.J., Simultaneous determination of cinnarizine and domperidone maleate from tablet dosage form by reverse phase ion pair high performance liquid chromatography (1999) J Pharm Biomed Anal, 19, pp. 813-817; Zarapkar, S.S., Kanyawar, N.S., Simultaneous estimation of domperidone and omeprazole in pharmaceutical dosage by reverse phase high performance liquid chromatography (2002) Indian Drugs, 39, pp. 217-221; Kobylinska, M., Kobylinska, K., High-performance liquid chromatographic analysis for the determination of domperidone in human plasma (2000) J Chromatogr B Biomed Sci Appl, 744, pp. 207-212; Zarapkar, S.S., Salunkhe, B.B., Determination of domperidone by high performance thinlayer chromatography in pharmaceutical preparations (1990) Indian Drugs, 27, pp. 537-540",
year = "2008",
doi = "10.4103/0250-474X.40351",
language = "English",
volume = "70",
pages = "128--131",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method. / Prabu, S.; Shirwaikar, A.; Kumar, C.; Joseph, A.; Kumar, R.

In: Indian Journal of Pharmaceutical Sciences, Vol. 70, No. 1, 2008, p. 128-131.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Simultaneous estimation of esomeprazole and domperidone by UV spectrophotometric method

AU - Prabu, S.

AU - Shirwaikar, A.

AU - Kumar, C.

AU - Joseph, A.

AU - Kumar, R.

N1 - Cited By :25 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India; email: arunshirwaikar@yahoo.co.in Chemicals/CAS: domperidone, 57808-66-9; esomeprazole, 119141-88-7, 202742-32-3, 217087-09-7, 217087-10-0 References: Andersson, T., Hassan-Alin, M., Hasselgren, G., Rohss, K., Weidolf, L., Pharmacokinetic studies with Esomeprazole, the (S)-Isomer of omeprazole (2001) Clinical Pharmacokinetics, 40, pp. 411-426; Scott, L.J., Dunn, C.J., Mallarkey, G., Sharpe, M., Esomeprazole- A review of its use in the management of acid-related disorders (2002) Drugs, 62, pp. 1503-1538; British Pharmacopoeia, 1, London: Her Majesty's Stationary Office; 1993. p. 519; Petersen, K.U., Schmutzler, W., Proton pump inhibitors release of active substance from various preparation (1999) Detsche Apotheker Zeitung, 139, pp. 68-69; Castro, D., Moreno, M.A., Torrado, S., Lastres, J.L., Comparison of derivative spectrophotometric and liquid chromatographic methods for the determination of omeprazole in aqueous solution during stability studies (1999) J Pharm Biomed Anal, 21, pp. 291-298; Ozaltin, N., Kocer, A., Determination of omeprazole in pharmaceuticals by derivative spectroscopy (1997) J Pharm Biomed Anal, 16, pp. 337-342; Dogrukol, A.K., Tunalier, Z., Tuncel, M., TLC densitometric determination of omeprazole in pharmaceutical preparations (1998) Pharmazie, 53, pp. 272-273; Sluggett, G.W., Stong, J.D., Adams, J.H., Zhao, Z., Omeprazole determination using HPLC with coulometric detection (2001) J Pharm Biomed Anal, 25, pp. 357-361; Mathew, M., Gupta, V.D., Bailery, R.E., Stability of omeprazole solutions at various pH values as determined by high performance liquid chromatography (1998) Drug Develop Ind Pharm, 21, pp. 965-971; Ding, L., Yang, J., Yan, H.L., Zhang, Z.X., An, D.K., Determination of omeprazole and its pharmacokinetic in human plasma by an improved HPLC method (1999) Chinese J Pharm Anal, 17, pp. 458-461; Shim, S.H., Bok, S.J., Kwon, K.I., Determination of omeprazole in rat plasma by HPLC with column switching (1994) Arch Pharm Res, 17, pp. 458-461; Zhi, X.J., Hunang, J., Zhang, J.H., Wang, H.T., Zhang, L.L., Determination of omeprazole and its metabolites in plasma by RP-HPLC (1999) Chinese J Pharm, 30, pp. 166-168; Motevalian, M., Saeedi, G., Keyhanfar, F., Tayebi, L., Mahmoudian, M., Simultaneous determination of omeprazole and its metabolites in human plasma by HPLC using solid phase extraction (1999) Pharm Pharmacol Commun, 5, pp. 265-268; Yeung, P.K., Little, R., Jiang, Y.Q., Buckley, S.J., Veldhuyzen, S.J., Zanten, V.N., Simple high performance liquid chromatography assay for simultaneous determination of omeprazole and metronidazole in human plasma and gastric fluid (1998) J Pharm Biomed Anal, 17, pp. 1393-1398; Kobayashi, K., Chiba, K.O., Sohn, D.R., Kato, Y., Ishizaki, T., Simultaneous determination of omeprazole and its metabolites in plasma and urine by reversed phase high performance liquid chromatography with an alkaline resistant polymer coated C18 column (1992) J Chromatogr B, 117, pp. 299-305; Amantea, M.A., Narang, P.K., Improved procedure for quantization of omeprazole and metabolites using reversed phase high performance liquid chromatography (1988) J Chromatogr A, 426, pp. 216-222; Hassan-Alin, M., Andersson, T., Bredberg, E., Rohss, K., Pharmacokinetics of esomeprazole after oral and intravenous administration of single and repeated doses to healthy subjects (2000) Eur J Clin Pharmacol, pp. 56-61,665-670; Johnson, D.A., Roach, A.C., Carlsson, A.S., Karlsson, A.A., Behr, D.E., Stability of esomeprazole capsule contents after in vitro suspension in common soft foods and beverages (2003) Pharmacotherapy, 23, pp. 731-734; Li, X.Q., Anderson, T.B., Ahlstrom, M., Weidolf, L., (2004) Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities Drug Metab Dispos, 32, pp. 821-827; Shetty, R., Subramanian, G., Ranjith Kumar, A., Pandey, S., Udupa, N., Estimation of esomeprazole in human plasma by reverse phase high performance liquid chromatography (2005) Indian Drugs, 42, pp. 158-161; Al Khamis, K.L., Hagga, M.E., Al-Khamis, H.A., Spectrophotometric determination of domperidone using absorbance difference method (1990) Anal Lett, 23, pp. 451-460; Ramamohan, Y., Avadhanulu, A.B., Extractive spectrophotometric determination of domperidone in its pharmaceutical dosage forms (1998) Indian Drugs, 35, pp. 754-756; Yamamoto, K., Hagino, M., Kotaki, H., Iga, I., Quantitative determination of domperidone in rat plasma by high performance liquid chromatography with fluorescence detection (1998) J Chromatogr B Biomed Appl, 720, pp. 252-255; Argekar, A.P., Shah, S.J., Simultaneous determination of cinnarizine and domperidone maleate from tablet dosage form by reverse phase ion pair high performance liquid chromatography (1999) J Pharm Biomed Anal, 19, pp. 813-817; Zarapkar, S.S., Kanyawar, N.S., Simultaneous estimation of domperidone and omeprazole in pharmaceutical dosage by reverse phase high performance liquid chromatography (2002) Indian Drugs, 39, pp. 217-221; Kobylinska, M., Kobylinska, K., High-performance liquid chromatographic analysis for the determination of domperidone in human plasma (2000) J Chromatogr B Biomed Sci Appl, 744, pp. 207-212; Zarapkar, S.S., Salunkhe, B.B., Determination of domperidone by high performance thinlayer chromatography in pharmaceutical preparations (1990) Indian Drugs, 27, pp. 537-540

PY - 2008

Y1 - 2008

N2 - A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 μg/ml and 8-30 μg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.

AB - A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, λ max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 μg/ml and 8-30 μg/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.

U2 - 10.4103/0250-474X.40351

DO - 10.4103/0250-474X.40351

M3 - Article

VL - 70

SP - 128

EP - 131

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 1

ER -