Simultaneous estimation of telmisartan, hydrochlorothiazide and amlodipine besylate in tablet preparation by chemometric asisted spectrophotometric analysis

A. S. Ghule, T. Thomas, M. Joseph, K. S. Navya Sree, K. Bhat

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A chemometric method was developed by application of Partial Least Square regression to for the simultaneous estimation of telmisartan, hydrochlorothiazide and amlodipine besylate in tablet preparations. Calibration set was prepared considering seven sets; each set with twenty-four mixed solutions and twenty-one ternary mixed solutions, were prepared as a validation set. The absorbance data matrix for training set was obtained by recording absorbance within wavelength range 220-320 nm at 2nm intervals. The developed method was validated according to ICH Q2 (R1) guidelines and results were reported. The developed and validated multivariate method was successfully tested for laboratory mixtures as well as commercial tablet formulation of telmisartan, hydrochlorothiazide and amlodipine besylate.

Original languageEnglish
Pages (from-to)59-66
Number of pages8
JournalIndian Drugs
Volume55
Issue number7
Publication statusPublished - 01-07-2018

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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