Single-Dose Oral Treatment of Vaginal Trichomoniasis with Tinidazole and Metronidazole

H. T.Manorama Rao, D. Radhakrishna Shenoy

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Abstract

Sixty cases of trichomonal vaginitis were randomly allocated to treatment with tinidazole or metronidazole, both administered as a 2 g single dose. One patient on tinidazole did not complete her follow-up. Parasitological cure was obtained in all patients in both the treatment groups. A satisfactory clinical response was obtained in all 29 patients on tinidazole, and in 27 out of 30 (90%) on metronidazole. Complete relief of symptoms was obtained in 62% (18/29) and 13% (4/30) of patients on tinidazole and metronidazole, respectively (p<0.01). Ten patients on tinidazole and 24 on metronidazole manifested side-effects. The frequency and severity of side-effects were much more in the metronidazole group (p <0.01). Tinidazole has distinct advantages over metronidazole in the one-dose treatment of trichomonal vaginitis.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalJournal of International Medical Research
Volume6
Issue number1
DOIs
Publication statusPublished - 01-01-1978
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

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