Six-year incidence of angle-closure disease in a South Indian population

The Chennai eye disease incidence study

Lingam Vijaya, Rashima Asokan, Manish Panday, Nikhil S. Choudhari, Sathyamangalam Ve Ramesh, Lokapavani Velumuri, Sachi Devi Boddupalli, Govindan T. Sunil, Ronnie George

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose To estimate the 6-year incidence of primary angle-closure (PAC) disease among adult population aged 40 years and older from rural and urban south India. Design Population-based longitudinal study. Methods A complete ophthalmologic examination, including applanation tonometry, gonioscopy, biometry, stereoscopic fundus examination, and automated perimetry was performed at both baseline and at the 6-year follow up at base hospital. Incident PAC disease was defined as the development of PAC disease during the 6-year follow-up in phakic subjects without PAC disease at baseline. Diagnosis was made using the International Society Geographical and Epidemiological Ophthalmology classification. Results The data were analyzed for 3350 subjects (mean age, 56.4 ± 8.9 years; 1547 males, 1803 females) for a diagnosis of PAC disease at baseline and at follow-up examinations. The incidence of PAC disease was identified in 134 subjects (6-year incidence rate, 4.0%; 95% confidence interval (CI), 3.3-4.7). Among the 134 subjects, 88 subjects (2.6%, 95% CI, 2.1-3.2) were primary angle-closure suspects; 37 subjects (1.1%, 95% CI, 0.7-1.5) had primary angle closure, and 9 subjects (0.3%, 95% CI, 0.1-0.4) had primary angle-closure glaucoma. There was an inverse relationship between the incidence of PAC disease and the cataract surgery rates. Significant risk factors for PAC disease on logistic regressions were higher intraocular pressure, increased lens thickness, shorter axial length, shallow anterior chamber depth, anteriorly positioned lens, and hyperopia. Conclusions The average incidence of PAC disease per year was 0.7%. All biometric parameters were found to be strong predictors for the incidence of PAC disease.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume156
Issue number6
DOIs
Publication statusPublished - 01-01-2013

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Eye Diseases
Cohort Studies
Incidence
Population
Confidence Intervals
Lenses
Gonioscopy
Biometry
Hyperopia
Angle Closure Glaucoma
Visual Field Tests
Manometry
Anterior Chamber
Ophthalmology
Intraocular Pressure
Cataract
Longitudinal Studies
India
Logistic Models

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Vijaya, Lingam ; Asokan, Rashima ; Panday, Manish ; Choudhari, Nikhil S. ; Ramesh, Sathyamangalam Ve ; Velumuri, Lokapavani ; Boddupalli, Sachi Devi ; Sunil, Govindan T. ; George, Ronnie. / Six-year incidence of angle-closure disease in a South Indian population : The Chennai eye disease incidence study. In: American Journal of Ophthalmology. 2013 ; Vol. 156, No. 6.
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abstract = "Purpose To estimate the 6-year incidence of primary angle-closure (PAC) disease among adult population aged 40 years and older from rural and urban south India. Design Population-based longitudinal study. Methods A complete ophthalmologic examination, including applanation tonometry, gonioscopy, biometry, stereoscopic fundus examination, and automated perimetry was performed at both baseline and at the 6-year follow up at base hospital. Incident PAC disease was defined as the development of PAC disease during the 6-year follow-up in phakic subjects without PAC disease at baseline. Diagnosis was made using the International Society Geographical and Epidemiological Ophthalmology classification. Results The data were analyzed for 3350 subjects (mean age, 56.4 ± 8.9 years; 1547 males, 1803 females) for a diagnosis of PAC disease at baseline and at follow-up examinations. The incidence of PAC disease was identified in 134 subjects (6-year incidence rate, 4.0{\%}; 95{\%} confidence interval (CI), 3.3-4.7). Among the 134 subjects, 88 subjects (2.6{\%}, 95{\%} CI, 2.1-3.2) were primary angle-closure suspects; 37 subjects (1.1{\%}, 95{\%} CI, 0.7-1.5) had primary angle closure, and 9 subjects (0.3{\%}, 95{\%} CI, 0.1-0.4) had primary angle-closure glaucoma. There was an inverse relationship between the incidence of PAC disease and the cataract surgery rates. Significant risk factors for PAC disease on logistic regressions were higher intraocular pressure, increased lens thickness, shorter axial length, shallow anterior chamber depth, anteriorly positioned lens, and hyperopia. Conclusions The average incidence of PAC disease per year was 0.7{\%}. All biometric parameters were found to be strong predictors for the incidence of PAC disease.",
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Six-year incidence of angle-closure disease in a South Indian population : The Chennai eye disease incidence study. / Vijaya, Lingam; Asokan, Rashima; Panday, Manish; Choudhari, Nikhil S.; Ramesh, Sathyamangalam Ve; Velumuri, Lokapavani; Boddupalli, Sachi Devi; Sunil, Govindan T.; George, Ronnie.

In: American Journal of Ophthalmology, Vol. 156, No. 6, 01.01.2013.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Six-year incidence of angle-closure disease in a South Indian population

T2 - The Chennai eye disease incidence study

AU - Vijaya, Lingam

AU - Asokan, Rashima

AU - Panday, Manish

AU - Choudhari, Nikhil S.

AU - Ramesh, Sathyamangalam Ve

AU - Velumuri, Lokapavani

AU - Boddupalli, Sachi Devi

AU - Sunil, Govindan T.

AU - George, Ronnie

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Purpose To estimate the 6-year incidence of primary angle-closure (PAC) disease among adult population aged 40 years and older from rural and urban south India. Design Population-based longitudinal study. Methods A complete ophthalmologic examination, including applanation tonometry, gonioscopy, biometry, stereoscopic fundus examination, and automated perimetry was performed at both baseline and at the 6-year follow up at base hospital. Incident PAC disease was defined as the development of PAC disease during the 6-year follow-up in phakic subjects without PAC disease at baseline. Diagnosis was made using the International Society Geographical and Epidemiological Ophthalmology classification. Results The data were analyzed for 3350 subjects (mean age, 56.4 ± 8.9 years; 1547 males, 1803 females) for a diagnosis of PAC disease at baseline and at follow-up examinations. The incidence of PAC disease was identified in 134 subjects (6-year incidence rate, 4.0%; 95% confidence interval (CI), 3.3-4.7). Among the 134 subjects, 88 subjects (2.6%, 95% CI, 2.1-3.2) were primary angle-closure suspects; 37 subjects (1.1%, 95% CI, 0.7-1.5) had primary angle closure, and 9 subjects (0.3%, 95% CI, 0.1-0.4) had primary angle-closure glaucoma. There was an inverse relationship between the incidence of PAC disease and the cataract surgery rates. Significant risk factors for PAC disease on logistic regressions were higher intraocular pressure, increased lens thickness, shorter axial length, shallow anterior chamber depth, anteriorly positioned lens, and hyperopia. Conclusions The average incidence of PAC disease per year was 0.7%. All biometric parameters were found to be strong predictors for the incidence of PAC disease.

AB - Purpose To estimate the 6-year incidence of primary angle-closure (PAC) disease among adult population aged 40 years and older from rural and urban south India. Design Population-based longitudinal study. Methods A complete ophthalmologic examination, including applanation tonometry, gonioscopy, biometry, stereoscopic fundus examination, and automated perimetry was performed at both baseline and at the 6-year follow up at base hospital. Incident PAC disease was defined as the development of PAC disease during the 6-year follow-up in phakic subjects without PAC disease at baseline. Diagnosis was made using the International Society Geographical and Epidemiological Ophthalmology classification. Results The data were analyzed for 3350 subjects (mean age, 56.4 ± 8.9 years; 1547 males, 1803 females) for a diagnosis of PAC disease at baseline and at follow-up examinations. The incidence of PAC disease was identified in 134 subjects (6-year incidence rate, 4.0%; 95% confidence interval (CI), 3.3-4.7). Among the 134 subjects, 88 subjects (2.6%, 95% CI, 2.1-3.2) were primary angle-closure suspects; 37 subjects (1.1%, 95% CI, 0.7-1.5) had primary angle closure, and 9 subjects (0.3%, 95% CI, 0.1-0.4) had primary angle-closure glaucoma. There was an inverse relationship between the incidence of PAC disease and the cataract surgery rates. Significant risk factors for PAC disease on logistic regressions were higher intraocular pressure, increased lens thickness, shorter axial length, shallow anterior chamber depth, anteriorly positioned lens, and hyperopia. Conclusions The average incidence of PAC disease per year was 0.7%. All biometric parameters were found to be strong predictors for the incidence of PAC disease.

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