Six-year incidence of ocular hypertension in a South Indian population: The Chennai eye disease incidence study

Manish Panday, Ronnie George, Rashima Asokan, Satyamangalam Ve Ramesh, Lokapavani Velumuri, Nikhil S. Choudhari, Sachi Devi Boddupalli, Govindan T. Sunil, Lingam Vijaya

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Abstract

Aims: To report the 6-year incidence and risk factors for ocular hypertension (OHT) in a population-based study in southern India. Methods: 6 years after baseline evaluation, 56.9% subjects (participants:non-participants, 4421:3353) were re-examined at the base hospital. Incident OHT was defined as an intraocular pressure above the 97.5th centile for the population with no evidence of glaucoma in the 2852 phakic subjects, 40 years or older. Subjects with trauma, laser or incisional surgery at baseline or follow-up were excluded (total exclusions: 1569). Results: Incidence of OHT at 6 years was 62/2852 subjects (2.17% (95% CI 1.64% to 2.71%, men: women, 36:26)). Incidence was higher in the rural cohort as compared with the urban cohort (80.6% vs 19.4%, p<0.001). A higher baseline intraocular pressure (with increasing OR: 16-18 mm Hg (OR 4.0, 95% CI 2.1 to 7.9), 19-21 mm Hg (OR 11.4, 95% CI 5.7 to 22.9), 22-24 mm Hg (OR 42.6, 95% CI 11.0 to 164.8, in the urban cohort)) and increasing age (50-59 years (OR 1.9, 95% CI 1.1 to 3.3), 70 years and above (OR 3.6, 95% CI 1.2 to 10.6)) were significantly associated risk factors for incident OHT. Conclusions: A significant proportion of this normal population converted to OHT. A higher incidence of conversion was seen in the rural population.

Original languageEnglish
Pages (from-to)604-608
Number of pages5
JournalBritish Journal of Ophthalmology
Volume99
Issue number5
DOIs
Publication statusPublished - 01-01-2015

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Ocular Hypertension
Eye Diseases
Cohort Studies
Incidence
Population
Intraocular Pressure
Rural Population
Glaucoma
India
Lasers
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Panday, Manish ; George, Ronnie ; Asokan, Rashima ; Ve Ramesh, Satyamangalam ; Velumuri, Lokapavani ; Choudhari, Nikhil S. ; Boddupalli, Sachi Devi ; Sunil, Govindan T. ; Vijaya, Lingam. / Six-year incidence of ocular hypertension in a South Indian population : The Chennai eye disease incidence study. In: British Journal of Ophthalmology. 2015 ; Vol. 99, No. 5. pp. 604-608.
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title = "Six-year incidence of ocular hypertension in a South Indian population: The Chennai eye disease incidence study",
abstract = "Aims: To report the 6-year incidence and risk factors for ocular hypertension (OHT) in a population-based study in southern India. Methods: 6 years after baseline evaluation, 56.9{\%} subjects (participants:non-participants, 4421:3353) were re-examined at the base hospital. Incident OHT was defined as an intraocular pressure above the 97.5th centile for the population with no evidence of glaucoma in the 2852 phakic subjects, 40 years or older. Subjects with trauma, laser or incisional surgery at baseline or follow-up were excluded (total exclusions: 1569). Results: Incidence of OHT at 6 years was 62/2852 subjects (2.17{\%} (95{\%} CI 1.64{\%} to 2.71{\%}, men: women, 36:26)). Incidence was higher in the rural cohort as compared with the urban cohort (80.6{\%} vs 19.4{\%}, p<0.001). A higher baseline intraocular pressure (with increasing OR: 16-18 mm Hg (OR 4.0, 95{\%} CI 2.1 to 7.9), 19-21 mm Hg (OR 11.4, 95{\%} CI 5.7 to 22.9), 22-24 mm Hg (OR 42.6, 95{\%} CI 11.0 to 164.8, in the urban cohort)) and increasing age (50-59 years (OR 1.9, 95{\%} CI 1.1 to 3.3), 70 years and above (OR 3.6, 95{\%} CI 1.2 to 10.6)) were significantly associated risk factors for incident OHT. Conclusions: A significant proportion of this normal population converted to OHT. A higher incidence of conversion was seen in the rural population.",
author = "Manish Panday and Ronnie George and Rashima Asokan and {Ve Ramesh}, Satyamangalam and Lokapavani Velumuri and Choudhari, {Nikhil S.} and Boddupalli, {Sachi Devi} and Sunil, {Govindan T.} and Lingam Vijaya",
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Panday, M, George, R, Asokan, R, Ve Ramesh, S, Velumuri, L, Choudhari, NS, Boddupalli, SD, Sunil, GT & Vijaya, L 2015, 'Six-year incidence of ocular hypertension in a South Indian population: The Chennai eye disease incidence study', British Journal of Ophthalmology, vol. 99, no. 5, pp. 604-608. https://doi.org/10.1136/bjophthalmol-2014-305714

Six-year incidence of ocular hypertension in a South Indian population : The Chennai eye disease incidence study. / Panday, Manish; George, Ronnie; Asokan, Rashima; Ve Ramesh, Satyamangalam; Velumuri, Lokapavani; Choudhari, Nikhil S.; Boddupalli, Sachi Devi; Sunil, Govindan T.; Vijaya, Lingam.

In: British Journal of Ophthalmology, Vol. 99, No. 5, 01.01.2015, p. 604-608.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Six-year incidence of ocular hypertension in a South Indian population

T2 - The Chennai eye disease incidence study

AU - Panday, Manish

AU - George, Ronnie

AU - Asokan, Rashima

AU - Ve Ramesh, Satyamangalam

AU - Velumuri, Lokapavani

AU - Choudhari, Nikhil S.

AU - Boddupalli, Sachi Devi

AU - Sunil, Govindan T.

AU - Vijaya, Lingam

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Aims: To report the 6-year incidence and risk factors for ocular hypertension (OHT) in a population-based study in southern India. Methods: 6 years after baseline evaluation, 56.9% subjects (participants:non-participants, 4421:3353) were re-examined at the base hospital. Incident OHT was defined as an intraocular pressure above the 97.5th centile for the population with no evidence of glaucoma in the 2852 phakic subjects, 40 years or older. Subjects with trauma, laser or incisional surgery at baseline or follow-up were excluded (total exclusions: 1569). Results: Incidence of OHT at 6 years was 62/2852 subjects (2.17% (95% CI 1.64% to 2.71%, men: women, 36:26)). Incidence was higher in the rural cohort as compared with the urban cohort (80.6% vs 19.4%, p<0.001). A higher baseline intraocular pressure (with increasing OR: 16-18 mm Hg (OR 4.0, 95% CI 2.1 to 7.9), 19-21 mm Hg (OR 11.4, 95% CI 5.7 to 22.9), 22-24 mm Hg (OR 42.6, 95% CI 11.0 to 164.8, in the urban cohort)) and increasing age (50-59 years (OR 1.9, 95% CI 1.1 to 3.3), 70 years and above (OR 3.6, 95% CI 1.2 to 10.6)) were significantly associated risk factors for incident OHT. Conclusions: A significant proportion of this normal population converted to OHT. A higher incidence of conversion was seen in the rural population.

AB - Aims: To report the 6-year incidence and risk factors for ocular hypertension (OHT) in a population-based study in southern India. Methods: 6 years after baseline evaluation, 56.9% subjects (participants:non-participants, 4421:3353) were re-examined at the base hospital. Incident OHT was defined as an intraocular pressure above the 97.5th centile for the population with no evidence of glaucoma in the 2852 phakic subjects, 40 years or older. Subjects with trauma, laser or incisional surgery at baseline or follow-up were excluded (total exclusions: 1569). Results: Incidence of OHT at 6 years was 62/2852 subjects (2.17% (95% CI 1.64% to 2.71%, men: women, 36:26)). Incidence was higher in the rural cohort as compared with the urban cohort (80.6% vs 19.4%, p<0.001). A higher baseline intraocular pressure (with increasing OR: 16-18 mm Hg (OR 4.0, 95% CI 2.1 to 7.9), 19-21 mm Hg (OR 11.4, 95% CI 5.7 to 22.9), 22-24 mm Hg (OR 42.6, 95% CI 11.0 to 164.8, in the urban cohort)) and increasing age (50-59 years (OR 1.9, 95% CI 1.1 to 3.3), 70 years and above (OR 3.6, 95% CI 1.2 to 10.6)) were significantly associated risk factors for incident OHT. Conclusions: A significant proportion of this normal population converted to OHT. A higher incidence of conversion was seen in the rural population.

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