Six-year incidence of visually significant age-related cataract: The Chennai eye disease incidence study

Manish Panday, Ronnie George, Rashima Asokan, Satyamangalam Ve Ramesh, Lokapavani Velumuri, Nikhil S. Choudhari, Sachi Devi Boddupalli, Govindan T. Sunil, Lingam Vijaya

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Abstract

Background: The aim of this study is to report the 6-year incidence of age-related cataract in a population-based study. Design: The design used is a population-based cohort study. Participants: A cohort of 2484 phakic subjects, aged 40years and above at baseline, from a south Indian population was included in the study. Methods: Bilateral phakics with visual acuity of 6/12 or better and cataract less than N2, C2 and P2 on the Lens Opacities Classification System II at baseline were included. Subjects with glaucoma and corneal or retinal diseases were excluded. Incident visually significant cataract was defined as visual acuity of less than 6/18 with a corresponding one grade or greater change in Lens Opacities Classification System II or history of having undergone cataract surgery with evidence of pseudophakia or aphakia at the 6-year follow-up. Main Outcome Measures: Six-year incidence of visually significant cataract and associated risk factors data were collected. Results: Incident visually significant cataract at 6years was seen in 158 subjects (6.36%, 95% CI: 5.40-7.32, phakics:pseudophakics/aphakics 70:88). Incidence was higher in the rural cohort as compared with the urban cohort (P<0.001). Incidence increased with age and was highest in the ≥70years age group (odds ratio (OR):31.23, 95% CI: 15.20-64.16, P<0.001). Other associated risk factors included illiteracy (OR 1.75, 95% CI: 1.17-2.61, P=0.007) and smoking (OR 1.77, 95% CI: 1.08-2.88, P=0.02). Conclusions: A significant proportion of the population developed visually significant age-related cataract at 6years. Incident visually significant cataract was significantly greater for the rural cohort between 50 and 69 years old.

Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalClinical and Experimental Ophthalmology
Volume44
Issue number2
DOIs
Publication statusPublished - 01-03-2016

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Eye Diseases
Cataract
Cohort Studies
Incidence
Odds Ratio
Population
Visual Acuity
Pseudophakia
Corneal Diseases
Aphakia
Retinal Diseases
Glaucoma
Age Groups
Smoking
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Panday, Manish ; George, Ronnie ; Asokan, Rashima ; Ve Ramesh, Satyamangalam ; Velumuri, Lokapavani ; Choudhari, Nikhil S. ; Boddupalli, Sachi Devi ; Sunil, Govindan T. ; Vijaya, Lingam. / Six-year incidence of visually significant age-related cataract : The Chennai eye disease incidence study. In: Clinical and Experimental Ophthalmology. 2016 ; Vol. 44, No. 2. pp. 114-120.
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title = "Six-year incidence of visually significant age-related cataract: The Chennai eye disease incidence study",
abstract = "Background: The aim of this study is to report the 6-year incidence of age-related cataract in a population-based study. Design: The design used is a population-based cohort study. Participants: A cohort of 2484 phakic subjects, aged 40years and above at baseline, from a south Indian population was included in the study. Methods: Bilateral phakics with visual acuity of 6/12 or better and cataract less than N2, C2 and P2 on the Lens Opacities Classification System II at baseline were included. Subjects with glaucoma and corneal or retinal diseases were excluded. Incident visually significant cataract was defined as visual acuity of less than 6/18 with a corresponding one grade or greater change in Lens Opacities Classification System II or history of having undergone cataract surgery with evidence of pseudophakia or aphakia at the 6-year follow-up. Main Outcome Measures: Six-year incidence of visually significant cataract and associated risk factors data were collected. Results: Incident visually significant cataract at 6years was seen in 158 subjects (6.36{\%}, 95{\%} CI: 5.40-7.32, phakics:pseudophakics/aphakics 70:88). Incidence was higher in the rural cohort as compared with the urban cohort (P<0.001). Incidence increased with age and was highest in the ≥70years age group (odds ratio (OR):31.23, 95{\%} CI: 15.20-64.16, P<0.001). Other associated risk factors included illiteracy (OR 1.75, 95{\%} CI: 1.17-2.61, P=0.007) and smoking (OR 1.77, 95{\%} CI: 1.08-2.88, P=0.02). Conclusions: A significant proportion of the population developed visually significant age-related cataract at 6years. Incident visually significant cataract was significantly greater for the rural cohort between 50 and 69 years old.",
author = "Manish Panday and Ronnie George and Rashima Asokan and {Ve Ramesh}, Satyamangalam and Lokapavani Velumuri and Choudhari, {Nikhil S.} and Boddupalli, {Sachi Devi} and Sunil, {Govindan T.} and Lingam Vijaya",
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Panday, M, George, R, Asokan, R, Ve Ramesh, S, Velumuri, L, Choudhari, NS, Boddupalli, SD, Sunil, GT & Vijaya, L 2016, 'Six-year incidence of visually significant age-related cataract: The Chennai eye disease incidence study', Clinical and Experimental Ophthalmology, vol. 44, no. 2, pp. 114-120. https://doi.org/10.1111/ceo.12636

Six-year incidence of visually significant age-related cataract : The Chennai eye disease incidence study. / Panday, Manish; George, Ronnie; Asokan, Rashima; Ve Ramesh, Satyamangalam; Velumuri, Lokapavani; Choudhari, Nikhil S.; Boddupalli, Sachi Devi; Sunil, Govindan T.; Vijaya, Lingam.

In: Clinical and Experimental Ophthalmology, Vol. 44, No. 2, 01.03.2016, p. 114-120.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Six-year incidence of visually significant age-related cataract

T2 - The Chennai eye disease incidence study

AU - Panday, Manish

AU - George, Ronnie

AU - Asokan, Rashima

AU - Ve Ramesh, Satyamangalam

AU - Velumuri, Lokapavani

AU - Choudhari, Nikhil S.

AU - Boddupalli, Sachi Devi

AU - Sunil, Govindan T.

AU - Vijaya, Lingam

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Background: The aim of this study is to report the 6-year incidence of age-related cataract in a population-based study. Design: The design used is a population-based cohort study. Participants: A cohort of 2484 phakic subjects, aged 40years and above at baseline, from a south Indian population was included in the study. Methods: Bilateral phakics with visual acuity of 6/12 or better and cataract less than N2, C2 and P2 on the Lens Opacities Classification System II at baseline were included. Subjects with glaucoma and corneal or retinal diseases were excluded. Incident visually significant cataract was defined as visual acuity of less than 6/18 with a corresponding one grade or greater change in Lens Opacities Classification System II or history of having undergone cataract surgery with evidence of pseudophakia or aphakia at the 6-year follow-up. Main Outcome Measures: Six-year incidence of visually significant cataract and associated risk factors data were collected. Results: Incident visually significant cataract at 6years was seen in 158 subjects (6.36%, 95% CI: 5.40-7.32, phakics:pseudophakics/aphakics 70:88). Incidence was higher in the rural cohort as compared with the urban cohort (P<0.001). Incidence increased with age and was highest in the ≥70years age group (odds ratio (OR):31.23, 95% CI: 15.20-64.16, P<0.001). Other associated risk factors included illiteracy (OR 1.75, 95% CI: 1.17-2.61, P=0.007) and smoking (OR 1.77, 95% CI: 1.08-2.88, P=0.02). Conclusions: A significant proportion of the population developed visually significant age-related cataract at 6years. Incident visually significant cataract was significantly greater for the rural cohort between 50 and 69 years old.

AB - Background: The aim of this study is to report the 6-year incidence of age-related cataract in a population-based study. Design: The design used is a population-based cohort study. Participants: A cohort of 2484 phakic subjects, aged 40years and above at baseline, from a south Indian population was included in the study. Methods: Bilateral phakics with visual acuity of 6/12 or better and cataract less than N2, C2 and P2 on the Lens Opacities Classification System II at baseline were included. Subjects with glaucoma and corneal or retinal diseases were excluded. Incident visually significant cataract was defined as visual acuity of less than 6/18 with a corresponding one grade or greater change in Lens Opacities Classification System II or history of having undergone cataract surgery with evidence of pseudophakia or aphakia at the 6-year follow-up. Main Outcome Measures: Six-year incidence of visually significant cataract and associated risk factors data were collected. Results: Incident visually significant cataract at 6years was seen in 158 subjects (6.36%, 95% CI: 5.40-7.32, phakics:pseudophakics/aphakics 70:88). Incidence was higher in the rural cohort as compared with the urban cohort (P<0.001). Incidence increased with age and was highest in the ≥70years age group (odds ratio (OR):31.23, 95% CI: 15.20-64.16, P<0.001). Other associated risk factors included illiteracy (OR 1.75, 95% CI: 1.17-2.61, P=0.007) and smoking (OR 1.77, 95% CI: 1.08-2.88, P=0.02). Conclusions: A significant proportion of the population developed visually significant age-related cataract at 6years. Incident visually significant cataract was significantly greater for the rural cohort between 50 and 69 years old.

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