Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity

A preliminary study

Paul Shapshak, Brian T. Foley, Seetharaman Balaji, David M. Segal, Clyde McCoy, J. Brian Page

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences-specifically hypervariable domains (V1-V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.

Original languageEnglish
Title of host publicationGlobal Virology II - HIV and NeuroAIDS
PublisherSpringer New York
Pages347-373
Number of pages27
ISBN (Electronic)9781493972906
ISBN (Print)9781493972883
DOIs
Publication statusPublished - 01-01-2017

Fingerprint

Drug Users
HIV
Injections
Pharmaceutical Preparations
Risk-Taking
Glycosylation
Thermodynamics
Cluster Analysis
Psychiatry
Morbidity
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Neuroscience(all)

Cite this

Shapshak, P., Foley, B. T., Balaji, S., Segal, D. M., McCoy, C., & Page, J. B. (2017). Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity: A preliminary study. In Global Virology II - HIV and NeuroAIDS (pp. 347-373). Springer New York. https://doi.org/10.1007/978-1-4939-7290-6_15
Shapshak, Paul ; Foley, Brian T. ; Balaji, Seetharaman ; Segal, David M. ; McCoy, Clyde ; Page, J. Brian. / Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity : A preliminary study. Global Virology II - HIV and NeuroAIDS. Springer New York, 2017. pp. 347-373
@inbook{4152ce67be5947ff9ce2d85fa5098a53,
title = "Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity: A preliminary study",
abstract = "Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences-specifically hypervariable domains (V1-V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.",
author = "Paul Shapshak and Foley, {Brian T.} and Seetharaman Balaji and Segal, {David M.} and Clyde McCoy and Page, {J. Brian}",
year = "2017",
month = "1",
day = "1",
doi = "10.1007/978-1-4939-7290-6_15",
language = "English",
isbn = "9781493972883",
pages = "347--373",
booktitle = "Global Virology II - HIV and NeuroAIDS",
publisher = "Springer New York",
address = "United States",

}

Shapshak, P, Foley, BT, Balaji, S, Segal, DM, McCoy, C & Page, JB 2017, Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity: A preliminary study. in Global Virology II - HIV and NeuroAIDS. Springer New York, pp. 347-373. https://doi.org/10.1007/978-1-4939-7290-6_15

Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity : A preliminary study. / Shapshak, Paul; Foley, Brian T.; Balaji, Seetharaman; Segal, David M.; McCoy, Clyde; Page, J. Brian.

Global Virology II - HIV and NeuroAIDS. Springer New York, 2017. p. 347-373.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity

T2 - A preliminary study

AU - Shapshak, Paul

AU - Foley, Brian T.

AU - Balaji, Seetharaman

AU - Segal, David M.

AU - McCoy, Clyde

AU - Page, J. Brian

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences-specifically hypervariable domains (V1-V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.

AB - Injection drug use is a major risk behavior associated with transmission of HIV-1B. Yet, despite its importance there have not been many detailed studies characterizing the transmission of HIV-1B in well-defined injection drug use networks. This preliminary study characterized people who were closely associated and injected drugs together under private circumstances compared to those who injected drugs in a context of public risk locales with many injectors in attendance. In this study, we examined networks of HIV-1B seropositive injection drug users (IDUs). We wished to ascertain whether socioepidemiological connections and relationships (including IDU and sexual) among individuals who inject drugs would be reflected in the molecular relatedness and clustering of their HIV-1B nucleotide and protein sequences-specifically hypervariable domains (V1-V5) of the HIV-1B envelope (env) gene. We wished to learn if there was a link between subject socioepidemiology and viral sequence diversity, phylogenetic relationships, signatures, thermodynamics, and glycosylation patterns. This chapter addresses whether in risk locales where many people inject together, there are variations in probability of relatedness of HIV-1B env sequences. In addition, it is pointed out that IDU behaviors are associated with psychiatric morbidities.

UR - http://www.scopus.com/inward/record.url?scp=85042625673&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042625673&partnerID=8YFLogxK

U2 - 10.1007/978-1-4939-7290-6_15

DO - 10.1007/978-1-4939-7290-6_15

M3 - Chapter

SN - 9781493972883

SP - 347

EP - 373

BT - Global Virology II - HIV and NeuroAIDS

PB - Springer New York

ER -

Shapshak P, Foley BT, Balaji S, Segal DM, McCoy C, Page JB. Socioepidemiology of injection drug users in Miami and HIV-1B envelope (V1-V5) genetic diversity: A preliminary study. In Global Virology II - HIV and NeuroAIDS. Springer New York. 2017. p. 347-373 https://doi.org/10.1007/978-1-4939-7290-6_15