Abstract

Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques for solid dispersion and compiles some of the recent technology transfers. The different types of solid dispersions based on the molecular arrangement have been highlighted. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization, along with an insight into the molecular arrangement of drugs in solid dispersions are also discussed. Finally, an in-depth rationale for limited commercialization of solid dispersions and recent revival has been considered.

Original languageEnglish
Pages (from-to)234-246
Number of pages13
JournalPakistan Journal of Pharmaceutical Sciences
Volume22
Issue number2
Publication statusPublished - 01-04-2009

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Technology Transfer
Pharmaceutical Preparations
Biological Availability

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Dhirendra, K. ; Lewis, S. ; Udupa, N. ; Atin, K. / Solid dispersions : a review. In: Pakistan Journal of Pharmaceutical Sciences. 2009 ; Vol. 22, No. 2. pp. 234-246.
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Dhirendra, K, Lewis, S, Udupa, N & Atin, K 2009, 'Solid dispersions: a review.', Pakistan Journal of Pharmaceutical Sciences, vol. 22, no. 2, pp. 234-246.

Solid dispersions : a review. / Dhirendra, K.; Lewis, S.; Udupa, N.; Atin, K.

In: Pakistan Journal of Pharmaceutical Sciences, Vol. 22, No. 2, 01.04.2009, p. 234-246.

Research output: Contribution to journalReview article

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AU - Lewis, S.

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AU - Atin, K.

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AB - Solid dispersions have attracted considerable interest as an efficient means of improving the dissolution rate and hence the bioavailability of a range of hydrophobic drugs. This article reviews the various preparation techniques for solid dispersion and compiles some of the recent technology transfers. The different types of solid dispersions based on the molecular arrangement have been highlighted. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection of carrier and methods of physicochemical characterization, along with an insight into the molecular arrangement of drugs in solid dispersions are also discussed. Finally, an in-depth rationale for limited commercialization of solid dispersions and recent revival has been considered.

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