Solitary fibrous tumour of the oral cavity: An update

Fernanda Bispo Nunes, Maria Sissa Pereira Sant'Ana, André Myller Barbosa Silva, Michelle Agostini, Nathalie Henriques Silva Canedo, Bruno Augusto Benevenuto de Andrade, Mário José Romañach, Davi Lavareda Corrêa, Ramiro Alejandro Tomasi, Raghu Radhakrishnan, Ricardo Santiago Gomez, Silvia Ferreira de Sousa, Peter A. Brennan, Felipe Paiva Fonseca

Research output: Contribution to journalReview article

Abstract

Background: Solitary fibrous tumour is an unusual neoplasm of the oral cavity that is sometimes not clinically distinguishable from other lesions. The purpose of the present study was to review the clinical, microscopic and molecular aspects of malignant and benign solitary fibrous tumour of the oral cavity currently available in literature. Methods: For our review, an electronic search was performed using PubMed, Scopus, Ovid/MedLine, Web of science and ProQuest Dissertations and Theses Global database. Results: A total of 74 publications reporting 150 cases were included. Oral solitary fibrous tumours are most frequently described as submucosal, well-circumscribed, asymptomatic nodule, more prevalent in females in their fourth to fifth decades of life. Buccal mucosa is the most commonly affected site by the benign tumour variant, whereas the tongue is the most common location affected by the malignant form of the neoplasm. Most of the lesions were treated by conservative surgery. One recurrent malignant tumour and one metastasis are reported. Conclusion: Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.

Original languageEnglish
JournalJournal of Oral Pathology and Medicine
DOIs
Publication statusAccepted/In press - 01-01-2019

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Solitary Fibrous Tumors
Mouth
Mouth Mucosa
Tongue
Neoplasms
PubMed
Cytogenetics
Publications
Immunohistochemistry
Databases
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

Nunes, F. B., Sant'Ana, M. S. P., Silva, A. M. B., Agostini, M., Silva Canedo, N. H., de Andrade, B. A. B., ... Fonseca, F. P. (Accepted/In press). Solitary fibrous tumour of the oral cavity: An update. Journal of Oral Pathology and Medicine. https://doi.org/10.1111/jop.12953
Nunes, Fernanda Bispo ; Sant'Ana, Maria Sissa Pereira ; Silva, André Myller Barbosa ; Agostini, Michelle ; Silva Canedo, Nathalie Henriques ; de Andrade, Bruno Augusto Benevenuto ; Romañach, Mário José ; Corrêa, Davi Lavareda ; Tomasi, Ramiro Alejandro ; Radhakrishnan, Raghu ; Gomez, Ricardo Santiago ; de Sousa, Silvia Ferreira ; Brennan, Peter A. ; Fonseca, Felipe Paiva. / Solitary fibrous tumour of the oral cavity : An update. In: Journal of Oral Pathology and Medicine. 2019.
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title = "Solitary fibrous tumour of the oral cavity: An update",
abstract = "Background: Solitary fibrous tumour is an unusual neoplasm of the oral cavity that is sometimes not clinically distinguishable from other lesions. The purpose of the present study was to review the clinical, microscopic and molecular aspects of malignant and benign solitary fibrous tumour of the oral cavity currently available in literature. Methods: For our review, an electronic search was performed using PubMed, Scopus, Ovid/MedLine, Web of science and ProQuest Dissertations and Theses Global database. Results: A total of 74 publications reporting 150 cases were included. Oral solitary fibrous tumours are most frequently described as submucosal, well-circumscribed, asymptomatic nodule, more prevalent in females in their fourth to fifth decades of life. Buccal mucosa is the most commonly affected site by the benign tumour variant, whereas the tongue is the most common location affected by the malignant form of the neoplasm. Most of the lesions were treated by conservative surgery. One recurrent malignant tumour and one metastasis are reported. Conclusion: Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.",
author = "Nunes, {Fernanda Bispo} and Sant'Ana, {Maria Sissa Pereira} and Silva, {Andr{\'e} Myller Barbosa} and Michelle Agostini and {Silva Canedo}, {Nathalie Henriques} and {de Andrade}, {Bruno Augusto Benevenuto} and Roma{\~n}ach, {M{\'a}rio Jos{\'e}} and Corr{\^e}a, {Davi Lavareda} and Tomasi, {Ramiro Alejandro} and Raghu Radhakrishnan and Gomez, {Ricardo Santiago} and {de Sousa}, {Silvia Ferreira} and Brennan, {Peter A.} and Fonseca, {Felipe Paiva}",
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Nunes, FB, Sant'Ana, MSP, Silva, AMB, Agostini, M, Silva Canedo, NH, de Andrade, BAB, Romañach, MJ, Corrêa, DL, Tomasi, RA, Radhakrishnan, R, Gomez, RS, de Sousa, SF, Brennan, PA & Fonseca, FP 2019, 'Solitary fibrous tumour of the oral cavity: An update', Journal of Oral Pathology and Medicine. https://doi.org/10.1111/jop.12953

Solitary fibrous tumour of the oral cavity : An update. / Nunes, Fernanda Bispo; Sant'Ana, Maria Sissa Pereira; Silva, André Myller Barbosa; Agostini, Michelle; Silva Canedo, Nathalie Henriques; de Andrade, Bruno Augusto Benevenuto; Romañach, Mário José; Corrêa, Davi Lavareda; Tomasi, Ramiro Alejandro; Radhakrishnan, Raghu; Gomez, Ricardo Santiago; de Sousa, Silvia Ferreira; Brennan, Peter A.; Fonseca, Felipe Paiva.

In: Journal of Oral Pathology and Medicine, 01.01.2019.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Solitary fibrous tumour of the oral cavity

T2 - An update

AU - Nunes, Fernanda Bispo

AU - Sant'Ana, Maria Sissa Pereira

AU - Silva, André Myller Barbosa

AU - Agostini, Michelle

AU - Silva Canedo, Nathalie Henriques

AU - de Andrade, Bruno Augusto Benevenuto

AU - Romañach, Mário José

AU - Corrêa, Davi Lavareda

AU - Tomasi, Ramiro Alejandro

AU - Radhakrishnan, Raghu

AU - Gomez, Ricardo Santiago

AU - de Sousa, Silvia Ferreira

AU - Brennan, Peter A.

AU - Fonseca, Felipe Paiva

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Solitary fibrous tumour is an unusual neoplasm of the oral cavity that is sometimes not clinically distinguishable from other lesions. The purpose of the present study was to review the clinical, microscopic and molecular aspects of malignant and benign solitary fibrous tumour of the oral cavity currently available in literature. Methods: For our review, an electronic search was performed using PubMed, Scopus, Ovid/MedLine, Web of science and ProQuest Dissertations and Theses Global database. Results: A total of 74 publications reporting 150 cases were included. Oral solitary fibrous tumours are most frequently described as submucosal, well-circumscribed, asymptomatic nodule, more prevalent in females in their fourth to fifth decades of life. Buccal mucosa is the most commonly affected site by the benign tumour variant, whereas the tongue is the most common location affected by the malignant form of the neoplasm. Most of the lesions were treated by conservative surgery. One recurrent malignant tumour and one metastasis are reported. Conclusion: Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.

AB - Background: Solitary fibrous tumour is an unusual neoplasm of the oral cavity that is sometimes not clinically distinguishable from other lesions. The purpose of the present study was to review the clinical, microscopic and molecular aspects of malignant and benign solitary fibrous tumour of the oral cavity currently available in literature. Methods: For our review, an electronic search was performed using PubMed, Scopus, Ovid/MedLine, Web of science and ProQuest Dissertations and Theses Global database. Results: A total of 74 publications reporting 150 cases were included. Oral solitary fibrous tumours are most frequently described as submucosal, well-circumscribed, asymptomatic nodule, more prevalent in females in their fourth to fifth decades of life. Buccal mucosa is the most commonly affected site by the benign tumour variant, whereas the tongue is the most common location affected by the malignant form of the neoplasm. Most of the lesions were treated by conservative surgery. One recurrent malignant tumour and one metastasis are reported. Conclusion: Asymptomatic normal-coloured submucosal nodules located in the buccal mucosa and tongue in adult patients are suggestive of oral solitary fibrous tumour, but only a careful microscopic examination can differentiate benign from malignant variants and the use of immunohistochemistry (CD34, Bcl-2, CD99 and STAT6), and cytogenetic studies (NAB2-STAT6) contribute significantly to confirm the diagnosis of solitary fibrous tumour in difficult cases.

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Nunes FB, Sant'Ana MSP, Silva AMB, Agostini M, Silva Canedo NH, de Andrade BAB et al. Solitary fibrous tumour of the oral cavity: An update. Journal of Oral Pathology and Medicine. 2019 Jan 1. https://doi.org/10.1111/jop.12953