Solubility interactions of trimethoprim and sulphamethoxazole in binary solvents

C.V.S. Subrahmanyam, C. Lalit Chowdary, M. Sreenivasa Reddy

Research output: Contribution to journalArticle

Abstract

The solubility of trimethoprim (TMP) and sulphamethoxazole (SMX) in binary solvents were studied to describe the solute-solvent interactions. Binary mixtures consisting of n-hexane-ethyl acetate, ethyl acetate-methanol and methanol-water systems were employed in this study. When solubilities were obtained for individual components, TMP exhibited solvation in ethyl acetate- methanol mixtures, while SMX showed weaker solute-solvent interactions in the above solvent series. At peak solubility, the solubility of SMX was around 8 times higher than that of TMP when these drugs were combined, SMX lowered the solubility of TMP to the tune of 13 to 74%. Similarly TMP suppressed the solubility of SMX to an extent of 10 to 94%. In water, though the mutual solubility was reduced, the solubility ratio of TMP to SMX was found to be 1:4 on the mole fraction scale. It is interesting because the dose ratio prescribed for TMP to SMX was 1:5. Evaluation of solubility parameters is difficult, because of the suppression of solubility by the other component.
Original languageUndefined/Unknown
Pages (from-to)195-199
Number of pages5
JournalIndian Drugs
Volume33
Issue number5
Publication statusPublished - 1996

Cite this

Subrahmanyam, C.V.S. ; Lalit Chowdary, C. ; Sreenivasa Reddy, M. / Solubility interactions of trimethoprim and sulphamethoxazole in binary solvents. In: Indian Drugs. 1996 ; Vol. 33, No. 5. pp. 195-199.
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abstract = "The solubility of trimethoprim (TMP) and sulphamethoxazole (SMX) in binary solvents were studied to describe the solute-solvent interactions. Binary mixtures consisting of n-hexane-ethyl acetate, ethyl acetate-methanol and methanol-water systems were employed in this study. When solubilities were obtained for individual components, TMP exhibited solvation in ethyl acetate- methanol mixtures, while SMX showed weaker solute-solvent interactions in the above solvent series. At peak solubility, the solubility of SMX was around 8 times higher than that of TMP when these drugs were combined, SMX lowered the solubility of TMP to the tune of 13 to 74{\%}. Similarly TMP suppressed the solubility of SMX to an extent of 10 to 94{\%}. In water, though the mutual solubility was reduced, the solubility ratio of TMP to SMX was found to be 1:4 on the mole fraction scale. It is interesting because the dose ratio prescribed for TMP to SMX was 1:5. Evaluation of solubility parameters is difficult, because of the suppression of solubility by the other component.",
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Subrahmanyam, CVS, Lalit Chowdary, C & Sreenivasa Reddy, M 1996, 'Solubility interactions of trimethoprim and sulphamethoxazole in binary solvents', Indian Drugs, vol. 33, no. 5, pp. 195-199.

Solubility interactions of trimethoprim and sulphamethoxazole in binary solvents. / Subrahmanyam, C.V.S.; Lalit Chowdary, C.; Sreenivasa Reddy, M.

In: Indian Drugs, Vol. 33, No. 5, 1996, p. 195-199.

Research output: Contribution to journalArticle

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AU - Subrahmanyam, C.V.S.

AU - Lalit Chowdary, C.

AU - Sreenivasa Reddy, M.

N1 - cited By 0

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N2 - The solubility of trimethoprim (TMP) and sulphamethoxazole (SMX) in binary solvents were studied to describe the solute-solvent interactions. Binary mixtures consisting of n-hexane-ethyl acetate, ethyl acetate-methanol and methanol-water systems were employed in this study. When solubilities were obtained for individual components, TMP exhibited solvation in ethyl acetate- methanol mixtures, while SMX showed weaker solute-solvent interactions in the above solvent series. At peak solubility, the solubility of SMX was around 8 times higher than that of TMP when these drugs were combined, SMX lowered the solubility of TMP to the tune of 13 to 74%. Similarly TMP suppressed the solubility of SMX to an extent of 10 to 94%. In water, though the mutual solubility was reduced, the solubility ratio of TMP to SMX was found to be 1:4 on the mole fraction scale. It is interesting because the dose ratio prescribed for TMP to SMX was 1:5. Evaluation of solubility parameters is difficult, because of the suppression of solubility by the other component.

AB - The solubility of trimethoprim (TMP) and sulphamethoxazole (SMX) in binary solvents were studied to describe the solute-solvent interactions. Binary mixtures consisting of n-hexane-ethyl acetate, ethyl acetate-methanol and methanol-water systems were employed in this study. When solubilities were obtained for individual components, TMP exhibited solvation in ethyl acetate- methanol mixtures, while SMX showed weaker solute-solvent interactions in the above solvent series. At peak solubility, the solubility of SMX was around 8 times higher than that of TMP when these drugs were combined, SMX lowered the solubility of TMP to the tune of 13 to 74%. Similarly TMP suppressed the solubility of SMX to an extent of 10 to 94%. In water, though the mutual solubility was reduced, the solubility ratio of TMP to SMX was found to be 1:4 on the mole fraction scale. It is interesting because the dose ratio prescribed for TMP to SMX was 1:5. Evaluation of solubility parameters is difficult, because of the suppression of solubility by the other component.

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