Spectrofluorimetric method for determination of citalopram in bulk and pharmaceutical dosage forms

S. Vasantharaju, S. Prabu, A. Jacob

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A simple accurate, sensitive reproducible spectrofluorimetric method was developed for the analysis of citalopram in pure and pharmaceutical dosage form. Citalopram showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 239 nm and emission at 300 nm. All parameters like the effect of different solvents, pH, dilutions, reaction time, temperature and effect of excipients were thoroughly investigated. The calibration graph was linear in the range from 0.100 to 0.900 mg/ml. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between 99.08% to 99.28%.
Original languageEnglish
Pages (from-to)647-648
Number of pages2
JournalIndian Journal of Pharmaceutical Sciences
Volume70
Issue number5
DOIs
Publication statusPublished - 2008

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