Spectrofluorimetric method for determination of granisetron hydrochloride in bulk and pharmaceutical dosage forms

A. Shirwaikar, S. L. Prabu, A. Joseph, R. S.J. Prakash

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6 Citations (Scopus)

Abstract

A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of granisetron hydrochloride in pure and pharmaceutical dosage form. Granisetron hydrochloride showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 237nm and emission at 307nm. The calibration graph was linear in the range from 0.025 to 0.150mcg/mL. LOD and LOQ was found to be 0.005 and 0.01mcg/mL respectively. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges from 99.33 % to 99.67 %.

Original languageEnglish
Pages (from-to)563-566
Number of pages4
JournalIndian Drugs
Volume45
Issue number7
Publication statusPublished - 01-07-2008

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

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