A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of granisetron hydrochloride in pure and pharmaceutical dosage form. Granisetron hydrochloride showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 237nm and emission at 307nm. The calibration graph was linear in the range from 0.025 to 0.150mcg/mL. LOD and LOQ was found to be 0.005 and 0.01mcg/mL respectively. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges from 99.33 % to 99.67 %.
|Number of pages||4|
|Publication status||Published - 01-07-2008|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science
- Drug Discovery