Spectrofluorimetric method for determination of granisetron hydrochloride in bulk and pharmaceutical dosage forms

A. Shirwaikar, S. L. Prabu, A. Joseph, R. S.J. Prakash

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of granisetron hydrochloride in pure and pharmaceutical dosage form. Granisetron hydrochloride showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 237nm and emission at 307nm. The calibration graph was linear in the range from 0.025 to 0.150mcg/mL. LOD and LOQ was found to be 0.005 and 0.01mcg/mL respectively. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges from 99.33 % to 99.67 %.

Original languageEnglish
Pages (from-to)563-566
Number of pages4
JournalIndian Drugs
Volume45
Issue number7
Publication statusPublished - 01-07-2008

Fingerprint

Granisetron
Dosage Forms
Pharmaceutical Preparations
Calibration
Tablets
Fluorescence
Acids

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Shirwaikar, A. ; Prabu, S. L. ; Joseph, A. ; Prakash, R. S.J. / Spectrofluorimetric method for determination of granisetron hydrochloride in bulk and pharmaceutical dosage forms. In: Indian Drugs. 2008 ; Vol. 45, No. 7. pp. 563-566.
@article{7971cfc68ceb48078e4ff8f1e934a1a4,
title = "Spectrofluorimetric method for determination of granisetron hydrochloride in bulk and pharmaceutical dosage forms",
abstract = "A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of granisetron hydrochloride in pure and pharmaceutical dosage form. Granisetron hydrochloride showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 237nm and emission at 307nm. The calibration graph was linear in the range from 0.025 to 0.150mcg/mL. LOD and LOQ was found to be 0.005 and 0.01mcg/mL respectively. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges from 99.33 {\%} to 99.67 {\%}.",
author = "A. Shirwaikar and Prabu, {S. L.} and A. Joseph and Prakash, {R. S.J.}",
year = "2008",
month = "7",
day = "1",
language = "English",
volume = "45",
pages = "563--566",
journal = "Indian Drugs",
issn = "0019-462X",
publisher = "Indian Drug Manufacturers' Association",
number = "7",

}

Spectrofluorimetric method for determination of granisetron hydrochloride in bulk and pharmaceutical dosage forms. / Shirwaikar, A.; Prabu, S. L.; Joseph, A.; Prakash, R. S.J.

In: Indian Drugs, Vol. 45, No. 7, 01.07.2008, p. 563-566.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Spectrofluorimetric method for determination of granisetron hydrochloride in bulk and pharmaceutical dosage forms

AU - Shirwaikar, A.

AU - Prabu, S. L.

AU - Joseph, A.

AU - Prakash, R. S.J.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of granisetron hydrochloride in pure and pharmaceutical dosage form. Granisetron hydrochloride showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 237nm and emission at 307nm. The calibration graph was linear in the range from 0.025 to 0.150mcg/mL. LOD and LOQ was found to be 0.005 and 0.01mcg/mL respectively. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges from 99.33 % to 99.67 %.

AB - A simple accurate, sensitive and reproducible spectrofluorimetric method was developed for the analysis of granisetron hydrochloride in pure and pharmaceutical dosage form. Granisetron hydrochloride showed strong native fluorescence in 0.05 M sulphuric acid having excitation at 237nm and emission at 307nm. The calibration graph was linear in the range from 0.025 to 0.150mcg/mL. LOD and LOQ was found to be 0.005 and 0.01mcg/mL respectively. The proposed method was statistically validated and successfully applied for analysis of tablet dosage forms. The percentage recovery was found to be between the ranges from 99.33 % to 99.67 %.

UR - http://www.scopus.com/inward/record.url?scp=77954936185&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954936185&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:77954936185

VL - 45

SP - 563

EP - 566

JO - Indian Drugs

JF - Indian Drugs

SN - 0019-462X

IS - 7

ER -