@article{a8c672f40f954cd1af76bb70c293004e,
title = "Spectrofluorimetric method for the determination of trifluoperazine hydrochloride in bulk and pharmaceutical dosage forms",
abstract = "A simple, precise and rapid fluorimetric method was developed for the determination of trifluoperazine hydrochloride in pharmaceutical dosage forms. Spectrofluorimetric method is based on the measurement of the native fluorescence and has always proved selective with relatively low detection limits. Trifluoperazine hydrochloride showed strong native fluorescence in water with excitation at 305.0 nm and emission at 480.0 nm. All parameters, viz; effect of different solvents and pH, were thoroughly investigated. The effect of potential interference due to common ingredients was investigated. The proposed method was statistically validated for linearity, accuracy and precision following International Conference on Harmonization, 1996 (ICH) recommendations and the USP (2003). Fluorescence intensity versus concentration in calibration graph was rectilinear in the range from 8 - 20 mcg/mL. The intra-day and inter-day precision were found to be 0.30 - 0.56, 0.43 - 0.71, respectively. The percent recovery was found to be 99.21±0.14. The method was successfully applied for the assay of trifluoperazine in pure form and in pharmaceutical dosage form.",
author = "S.G. Vasantharaju and {Lakshmana Prabu}, S. and A. Jacob and P.C. Jagdish and N. Sivagurunathan",
note = "Export Date: 10 November 2017 CODEN: INDRB Correspondence Address: Vasantharaju, S. G.; Manipal College of Pharmaceutical Sciences, Manipal - 576 104 Karnataka, India; email: sgvasanth65@gmall.com Chemicals/CAS: trifluoperazine, 117-89-5, 440-17-5; water, 7732-18-5 References: (2003) United States Pharmacopoeia/NF, p. 1880. , 26th edn., The US Pharmacopoeia Convention, Inc., Rockville, MD; (1996) Indian Pharmacopoeia, 2, p. 775. , 4th edn., Government of India, Ministry of Health and Family Welfare, New Delhi; Waston, J.R., Trifluoperazine tablets: Alternative methods of analysis (1970) J. Pharm. Sci., 59, p. 391; Saudagar, R.B., Swarnlata, S., Saraf, S., Spectrophotometric determination of chlordiazepoxide and trifluoperazine hydrochloride from combined dosage form (2007) Ind. J. Pharm. Sci., 69, p. 149; Zarapkar, S.S., Athalye, K.R., New colorimetric method of estimation of promethazine HCI, promethazine theoclate and pentazine (1988) Indian Drugs, 26, p. 32; El-Gindy, A., El-Zeany, B.T., Shabana, M.M., Spectrophotometric determination of trifluoperazine HCI and isopropamide iodide in binary mixture using second derivative and second derivative of the ratio spectra methods (2001) J. Pharm. Biomed. Anal., 26, p. 203; El-Gindy, A., El-Zeany, B.T., Shabana, M.M., Derivative spectrophotometric, thin layer chromatographic-densitometric and high performance liquid chromatographic determination of trifluoperazine hydrochloride in presence of its hydrogen peroxide induced-degradation product (2002) J. Pharm. Biomed. Anal., 32, p. 9; Abdel-Moety, E.M., Al-Rashood, K.A., Rauf, A., Khattab, N.A., Photostability-indicating HPLC method for determination of trifluoperazine in bulk form and pharmaceutical formulations (1996) J. Pharm. Biomed. Anal., 14 (11), pp. 1639-1644; Desai, S.M., Khatri, J.M., Lalla, J.K., HPLC determination of chlorpromazine HCI and trifluoperazine HCI from controlled release suspension (1990) Indian Drugs, 27, p. 389; Mahadik, K.R., Aggarwal, H., Kaul, N., Simultaneous HPTLC estimation of trifluoperazine, trihexyphenidyl HCI and chlorpromazine HCI in tablet dosage form (2003) Indian Drugs, 40, p. 340",
year = "2008",
language = "English",
volume = "45",
pages = "821--823",
journal = "Indian Drugs",
issn = "0019-462X",
publisher = "Indian Drug Manufacturers' Association",
number = "10",
}