Spectrum of Imaging Findings in Paget’s Disease of the Breast—A Pictorial Review

Smiti Sripathi, Anurag Ayachit, Rajagopal Kadavigere, Sandeep Kumar, Asha Eleti, Aron Sraj

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Purpose: We aimed to demonstrate imaging features of Paget’s disease of breast, which is an extremely uncommon malignancy that presents with changes in the nipple-areolar region that may or may not be associated with an underlying in situ component or invasive cancer. Methods and Results: Mammography is the initial investigation of choice, having a high sensitivity especially in cases where a palpable mass is present. The addition of ultrasound improves the accuracy of mammography. When both mammography and ultrasound are negative, MRI may detect an underlying mass or ductal carcinoma in situ (DCIS). Conclusion: The surgical management of Paget’s disease includes mastectomy with or without axillary dissection, though breast conservation surgery in the form of wide local excision can also be done in a selected group of patients. Management should be based on both clinical and imaging findings, including mammography and ultrasound, with MRI playing a crucial role in defining the extent of involvement. Teaching Points • To differentiate Paget’s disease from other chronic skin conditions. • Mammographic and ultrasound findings of histopathologically established Paget’s disease. • When ultrasound and mammogram are negative, MRI may detect underlying malignancy.

Original languageEnglish
Pages (from-to)419-429
Number of pages11
JournalInsights into Imaging
Volume6
Issue number4
DOIs
Publication statusPublished - 29-08-2015

Fingerprint

Mammary Ultrasonography
Mammography
Mammary Paget's Disease
Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Nipples
Mastectomy
Disease Management
Dissection
Teaching
Breast
Chronic Disease
Skin

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Sripathi, Smiti ; Ayachit, Anurag ; Kadavigere, Rajagopal ; Kumar, Sandeep ; Eleti, Asha ; Sraj, Aron. / Spectrum of Imaging Findings in Paget’s Disease of the Breast—A Pictorial Review. In: Insights into Imaging. 2015 ; Vol. 6, No. 4. pp. 419-429.
@article{9815ae022a0a46d89cbd0911e2e7879f,
title = "Spectrum of Imaging Findings in Paget’s Disease of the Breast—A Pictorial Review",
abstract = "Purpose: We aimed to demonstrate imaging features of Paget’s disease of breast, which is an extremely uncommon malignancy that presents with changes in the nipple-areolar region that may or may not be associated with an underlying in situ component or invasive cancer. Methods and Results: Mammography is the initial investigation of choice, having a high sensitivity especially in cases where a palpable mass is present. The addition of ultrasound improves the accuracy of mammography. When both mammography and ultrasound are negative, MRI may detect an underlying mass or ductal carcinoma in situ (DCIS). Conclusion: The surgical management of Paget’s disease includes mastectomy with or without axillary dissection, though breast conservation surgery in the form of wide local excision can also be done in a selected group of patients. Management should be based on both clinical and imaging findings, including mammography and ultrasound, with MRI playing a crucial role in defining the extent of involvement. Teaching Points • To differentiate Paget’s disease from other chronic skin conditions. • Mammographic and ultrasound findings of histopathologically established Paget’s disease. • When ultrasound and mammogram are negative, MRI may detect underlying malignancy.",
author = "Smiti Sripathi and Anurag Ayachit and Rajagopal Kadavigere and Sandeep Kumar and Asha Eleti and Aron Sraj",
year = "2015",
month = "8",
day = "29",
doi = "10.1007/s13244-015-0415-z",
language = "English",
volume = "6",
pages = "419--429",
journal = "Insights into Imaging",
issn = "1869-4101",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "4",

}

Spectrum of Imaging Findings in Paget’s Disease of the Breast—A Pictorial Review. / Sripathi, Smiti; Ayachit, Anurag; Kadavigere, Rajagopal; Kumar, Sandeep; Eleti, Asha; Sraj, Aron.

In: Insights into Imaging, Vol. 6, No. 4, 29.08.2015, p. 419-429.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Spectrum of Imaging Findings in Paget’s Disease of the Breast—A Pictorial Review

AU - Sripathi, Smiti

AU - Ayachit, Anurag

AU - Kadavigere, Rajagopal

AU - Kumar, Sandeep

AU - Eleti, Asha

AU - Sraj, Aron

PY - 2015/8/29

Y1 - 2015/8/29

N2 - Purpose: We aimed to demonstrate imaging features of Paget’s disease of breast, which is an extremely uncommon malignancy that presents with changes in the nipple-areolar region that may or may not be associated with an underlying in situ component or invasive cancer. Methods and Results: Mammography is the initial investigation of choice, having a high sensitivity especially in cases where a palpable mass is present. The addition of ultrasound improves the accuracy of mammography. When both mammography and ultrasound are negative, MRI may detect an underlying mass or ductal carcinoma in situ (DCIS). Conclusion: The surgical management of Paget’s disease includes mastectomy with or without axillary dissection, though breast conservation surgery in the form of wide local excision can also be done in a selected group of patients. Management should be based on both clinical and imaging findings, including mammography and ultrasound, with MRI playing a crucial role in defining the extent of involvement. Teaching Points • To differentiate Paget’s disease from other chronic skin conditions. • Mammographic and ultrasound findings of histopathologically established Paget’s disease. • When ultrasound and mammogram are negative, MRI may detect underlying malignancy.

AB - Purpose: We aimed to demonstrate imaging features of Paget’s disease of breast, which is an extremely uncommon malignancy that presents with changes in the nipple-areolar region that may or may not be associated with an underlying in situ component or invasive cancer. Methods and Results: Mammography is the initial investigation of choice, having a high sensitivity especially in cases where a palpable mass is present. The addition of ultrasound improves the accuracy of mammography. When both mammography and ultrasound are negative, MRI may detect an underlying mass or ductal carcinoma in situ (DCIS). Conclusion: The surgical management of Paget’s disease includes mastectomy with or without axillary dissection, though breast conservation surgery in the form of wide local excision can also be done in a selected group of patients. Management should be based on both clinical and imaging findings, including mammography and ultrasound, with MRI playing a crucial role in defining the extent of involvement. Teaching Points • To differentiate Paget’s disease from other chronic skin conditions. • Mammographic and ultrasound findings of histopathologically established Paget’s disease. • When ultrasound and mammogram are negative, MRI may detect underlying malignancy.

UR - http://www.scopus.com/inward/record.url?scp=84938360336&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938360336&partnerID=8YFLogxK

U2 - 10.1007/s13244-015-0415-z

DO - 10.1007/s13244-015-0415-z

M3 - Review article

AN - SCOPUS:84938360336

VL - 6

SP - 419

EP - 429

JO - Insights into Imaging

JF - Insights into Imaging

SN - 1869-4101

IS - 4

ER -