Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases

Mahesha Vankalakunti, A. Rohan, S. Vishwanath, S. Rampure, R. Bonu, K. Babu, H. Ballal

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6 Citations (Scopus)

Abstract

Spectrum of causes for renal dysfunction in patients with hematolymphoid malignancy (excluding plasma cell dyscrasia) is varied. A retrospective evaluation of native renal biopsies referred to our institute during the period from January 2010 to December 2013 revealed 12 cases. Age ranged between 7 and 69 (median 54.5) years. All patients were males. The neoplasms included non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute lymphoblastic leukemia, Burkitt's lymphoma, intravascular lymphoma, Hodgkin lymphoma and chronic myeloid leukemia. Proteinuria was noted in 66% of the patients (nephrotic range in 5, subnephrotic range in 3). Renal insufficiency was noted in 100% patients. Malignancy-related kidney injury was noted in 75% of the cases. Renal histology showed lymphomatous infiltration (8), membranoproliferative glomerulonephritis (MPGN) (3), intracapillary monoclonal deposit disease (1) and intravascular lymphoma (1). Distribution of lymphomatous infiltration was diffuse in 50% and focal in 50%. We observed that renal dysfunction was predominantly a direct effect, that is, lymphomatous invasion. Paraneoplastic glomerulopathic changes occur in the form of MPGN. Proteinuria of >2 g/day correlated with glomerular disease.

Original languageEnglish
Pages (from-to)201-205
Number of pages5
JournalIndian Journal of Nephrology
Volume25
Issue number4
DOIs
Publication statusPublished - 01-07-2015

All Science Journal Classification (ASJC) codes

  • Nephrology

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    Vankalakunti, M., Rohan, A., Vishwanath, S., Rampure, S., Bonu, R., Babu, K., & Ballal, H. (2015). Spectrum of renal involvement in hematolymphoid neoplasms: Renal biopsy findings of 12 cases. Indian Journal of Nephrology, 25(4), 201-205. https://doi.org/10.4103/0971-4065.139093