Spink1 mutation in idiopathic recurrent acute pancreatitis-pilot study

Shiran Shetty, Thaiagarajan Sairam, Krishnaveni Janarthanan, Venkatakrishnan Leelakrishnan, Ramalingam Sankaran

Research output: Contribution to journalArticle

Abstract

Introduction: Recurrent Acute Pancreatitis (RAP) and Chronic Pancreatitis (CP) are labeled as idiopathic when no identifiable factors are found. The identifications of genetic mutations associated with pancreatitis have provided opportunities for identifying patients at risk for idiopathic pancreatitis. Aim: The aim of the present study was to study the clinical profile and prevalence of SPINK1 mutation in idiopathic RAP. Materials and Methods: The present study was a prospective observational study of idiopathic RAP patients at a tertiary care hospital. DNA was isolated from blood obtained from patients and genotyping of SPINK1 mutation was studied. Results: A total of 17 patients with idiopathic RAP were included. Their mean age was 22.29±9.7 years, 14 (82%) were male, 7 (41.7%) had SPINK1 mutation. Patients with SPINK1 mutations had more frequent acute episodes of pancreatitis. Conclusion: SPINK1 mutation patients have more frequent acute episodes of pancreatitis and nearly 7 (41.7%) had SPINK1 mutations in the so called idiopathic RAP. Genetic testing in idiopathic pancreatitis might have role in future. Multicenter studies are further required to confirm the role of genetic testing in RAP.

Original languageEnglish
Pages (from-to)OC15-OC17
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number3
DOIs
Publication statusPublished - 01-03-2018

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Pancreatitis
Mutation
Testing
Blood
DNA
Genetic Testing
Chronic Pancreatitis
Tertiary Healthcare
Tertiary Care Centers
Multicenter Studies
Observational Studies
Cross-Sectional Studies
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Shetty, Shiran ; Sairam, Thaiagarajan ; Janarthanan, Krishnaveni ; Leelakrishnan, Venkatakrishnan ; Sankaran, Ramalingam. / Spink1 mutation in idiopathic recurrent acute pancreatitis-pilot study. In: Journal of Clinical and Diagnostic Research. 2018 ; Vol. 12, No. 3. pp. OC15-OC17.
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abstract = "Introduction: Recurrent Acute Pancreatitis (RAP) and Chronic Pancreatitis (CP) are labeled as idiopathic when no identifiable factors are found. The identifications of genetic mutations associated with pancreatitis have provided opportunities for identifying patients at risk for idiopathic pancreatitis. Aim: The aim of the present study was to study the clinical profile and prevalence of SPINK1 mutation in idiopathic RAP. Materials and Methods: The present study was a prospective observational study of idiopathic RAP patients at a tertiary care hospital. DNA was isolated from blood obtained from patients and genotyping of SPINK1 mutation was studied. Results: A total of 17 patients with idiopathic RAP were included. Their mean age was 22.29±9.7 years, 14 (82{\%}) were male, 7 (41.7{\%}) had SPINK1 mutation. Patients with SPINK1 mutations had more frequent acute episodes of pancreatitis. Conclusion: SPINK1 mutation patients have more frequent acute episodes of pancreatitis and nearly 7 (41.7{\%}) had SPINK1 mutations in the so called idiopathic RAP. Genetic testing in idiopathic pancreatitis might have role in future. Multicenter studies are further required to confirm the role of genetic testing in RAP.",
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Spink1 mutation in idiopathic recurrent acute pancreatitis-pilot study. / Shetty, Shiran; Sairam, Thaiagarajan; Janarthanan, Krishnaveni; Leelakrishnan, Venkatakrishnan; Sankaran, Ramalingam.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 3, 01.03.2018, p. OC15-OC17.

Research output: Contribution to journalArticle

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AU - Shetty, Shiran

AU - Sairam, Thaiagarajan

AU - Janarthanan, Krishnaveni

AU - Leelakrishnan, Venkatakrishnan

AU - Sankaran, Ramalingam

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N2 - Introduction: Recurrent Acute Pancreatitis (RAP) and Chronic Pancreatitis (CP) are labeled as idiopathic when no identifiable factors are found. The identifications of genetic mutations associated with pancreatitis have provided opportunities for identifying patients at risk for idiopathic pancreatitis. Aim: The aim of the present study was to study the clinical profile and prevalence of SPINK1 mutation in idiopathic RAP. Materials and Methods: The present study was a prospective observational study of idiopathic RAP patients at a tertiary care hospital. DNA was isolated from blood obtained from patients and genotyping of SPINK1 mutation was studied. Results: A total of 17 patients with idiopathic RAP were included. Their mean age was 22.29±9.7 years, 14 (82%) were male, 7 (41.7%) had SPINK1 mutation. Patients with SPINK1 mutations had more frequent acute episodes of pancreatitis. Conclusion: SPINK1 mutation patients have more frequent acute episodes of pancreatitis and nearly 7 (41.7%) had SPINK1 mutations in the so called idiopathic RAP. Genetic testing in idiopathic pancreatitis might have role in future. Multicenter studies are further required to confirm the role of genetic testing in RAP.

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