Abstract

We describe a case of a 40-year-old male patient who was found to have multiple myeloma with spontaneous tumour lysis syndrome (TLS), following a compression fracture of the L-2 vertebrae. Multiple myeloma was confirmed by bone marrow analysis and the M-band on serum protein electrophoresis. Hyperuricaemia (26.2 mg/dL), hyperkalaemia (> 7.0 mEq/L), hyperphosphatemia (16.2 mg of phosphorus/dL), normocalcemia and acute kidney injury, prior to anticancer treatment suggested spontaneous TLS. Inciting events for tumour lysis, such as chemotherapy, dehydration and exposure to steroids were absent. Patient received hydration, hypourecemic drugs and haemodialysis. This case report highlights the rare presentation of multiple myeloma with spontaneous TLS.

Original languageEnglish
Pages (from-to)168-171
Number of pages4
JournalAustralasian Medical Journal
Volume6
Issue number3
DOIs
Publication statusPublished - 05-04-2013

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Tumor Lysis Syndrome
Multiple Myeloma
Hyperphosphatemia
Compression Fractures
Hyperkalemia
Dehydration
Acute Kidney Injury
Phosphorus
Renal Dialysis
Electrophoresis
Blood Proteins
Spine
Bone Marrow
Steroids
Drug Therapy
Pharmaceutical Preparations
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "We describe a case of a 40-year-old male patient who was found to have multiple myeloma with spontaneous tumour lysis syndrome (TLS), following a compression fracture of the L-2 vertebrae. Multiple myeloma was confirmed by bone marrow analysis and the M-band on serum protein electrophoresis. Hyperuricaemia (26.2 mg/dL), hyperkalaemia (> 7.0 mEq/L), hyperphosphatemia (16.2 mg of phosphorus/dL), normocalcemia and acute kidney injury, prior to anticancer treatment suggested spontaneous TLS. Inciting events for tumour lysis, such as chemotherapy, dehydration and exposure to steroids were absent. Patient received hydration, hypourecemic drugs and haemodialysis. This case report highlights the rare presentation of multiple myeloma with spontaneous TLS.",
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Spontaneous tumour lysis syndrome in a case of multiple myeloma - A rare occurrence. / Saravu, Kavitha; Kumar, Suresh; Shastry, Ananthakrishna Barkur; Kurien, Annamma; Prabhu, Ravindra; Kumar, Rishikesh.

In: Australasian Medical Journal, Vol. 6, No. 3, 05.04.2013, p. 168-171.

Research output: Contribution to journalArticle

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