SRD5A2 gene polymorphisms affect the risk of breast cancer

Amirtharaj Francis, Saumya Sarkar, Singh Pooja, Daminani Surekha, Digumarthi Raghunatha Rao, Lakshmi Rao, Lingadakai Ramachandra, Satti Vishnupriya, Kapaettu Satyamoorthy, Kumarasamy Thangaraj, Singh Rajender

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Androgens in breast cancer have been studied alone and in correlation with estrogens as estrogen to testosterone ratio. 5-α-reductase is one of the important enzymes participating in androgen metabolism, which affects androgen activity by affecting conversion of testosterone to dihydrotestosterone. We hypothesized that polymorphisms in the SRD5A2 gene (encoding 5-α-reductase) may affect breast cancer risk by affecting total androgen activity. Complete coding region of the SRD5A2 gene was sequenced in a group of 628 patients and 244 control samples from three southern states (Tamil Nadu, Andhra Pradesh, and Karnataka) of India. We observed three common polymorphisms in this gene namely, A49T, V89L, and (TA)n repeats. A49T locus was monomorphic in the study population, but V89L showed a strong correlation with breast cancer (P=0.03, OR=1.40, CI=1.02-1.91). (TA)0/(TA)9 and (TA)9/(TA)9 genotypes were at a lower risk of breast cancer (P=0.01, OR=0.64, CI=0.46-0.90). We conclude that SRD5A2 genotypes significantly affect breast cancer risk in the South Indian populations.

Original languageEnglish
Pages (from-to)137-141
Number of pages5
JournalBreast
Volume23
Issue number2
DOIs
Publication statusPublished - 2014

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Androgens
Breast Neoplasms
Genes
Testosterone
Oxidoreductases
Estrogens
Genotype
Dihydrotestosterone
Population
India
Enzymes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Medicine(all)

Cite this

Francis, A., Sarkar, S., Pooja, S., Surekha, D., Rao, D. R., Rao, L., ... Rajender, S. (2014). SRD5A2 gene polymorphisms affect the risk of breast cancer. Breast, 23(2), 137-141. https://doi.org/10.1016/j.breast.2013.11.010
Francis, Amirtharaj ; Sarkar, Saumya ; Pooja, Singh ; Surekha, Daminani ; Rao, Digumarthi Raghunatha ; Rao, Lakshmi ; Ramachandra, Lingadakai ; Vishnupriya, Satti ; Satyamoorthy, Kapaettu ; Thangaraj, Kumarasamy ; Rajender, Singh. / SRD5A2 gene polymorphisms affect the risk of breast cancer. In: Breast. 2014 ; Vol. 23, No. 2. pp. 137-141.
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abstract = "Androgens in breast cancer have been studied alone and in correlation with estrogens as estrogen to testosterone ratio. 5-α-reductase is one of the important enzymes participating in androgen metabolism, which affects androgen activity by affecting conversion of testosterone to dihydrotestosterone. We hypothesized that polymorphisms in the SRD5A2 gene (encoding 5-α-reductase) may affect breast cancer risk by affecting total androgen activity. Complete coding region of the SRD5A2 gene was sequenced in a group of 628 patients and 244 control samples from three southern states (Tamil Nadu, Andhra Pradesh, and Karnataka) of India. We observed three common polymorphisms in this gene namely, A49T, V89L, and (TA)n repeats. A49T locus was monomorphic in the study population, but V89L showed a strong correlation with breast cancer (P=0.03, OR=1.40, CI=1.02-1.91). (TA)0/(TA)9 and (TA)9/(TA)9 genotypes were at a lower risk of breast cancer (P=0.01, OR=0.64, CI=0.46-0.90). We conclude that SRD5A2 genotypes significantly affect breast cancer risk in the South Indian populations.",
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Francis, A, Sarkar, S, Pooja, S, Surekha, D, Rao, DR, Rao, L, Ramachandra, L, Vishnupriya, S, Satyamoorthy, K, Thangaraj, K & Rajender, S 2014, 'SRD5A2 gene polymorphisms affect the risk of breast cancer', Breast, vol. 23, no. 2, pp. 137-141. https://doi.org/10.1016/j.breast.2013.11.010

SRD5A2 gene polymorphisms affect the risk of breast cancer. / Francis, Amirtharaj; Sarkar, Saumya; Pooja, Singh; Surekha, Daminani; Rao, Digumarthi Raghunatha; Rao, Lakshmi; Ramachandra, Lingadakai; Vishnupriya, Satti; Satyamoorthy, Kapaettu; Thangaraj, Kumarasamy; Rajender, Singh.

In: Breast, Vol. 23, No. 2, 2014, p. 137-141.

Research output: Contribution to journalArticle

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T1 - SRD5A2 gene polymorphisms affect the risk of breast cancer

AU - Francis, Amirtharaj

AU - Sarkar, Saumya

AU - Pooja, Singh

AU - Surekha, Daminani

AU - Rao, Digumarthi Raghunatha

AU - Rao, Lakshmi

AU - Ramachandra, Lingadakai

AU - Vishnupriya, Satti

AU - Satyamoorthy, Kapaettu

AU - Thangaraj, Kumarasamy

AU - Rajender, Singh

PY - 2014

Y1 - 2014

N2 - Androgens in breast cancer have been studied alone and in correlation with estrogens as estrogen to testosterone ratio. 5-α-reductase is one of the important enzymes participating in androgen metabolism, which affects androgen activity by affecting conversion of testosterone to dihydrotestosterone. We hypothesized that polymorphisms in the SRD5A2 gene (encoding 5-α-reductase) may affect breast cancer risk by affecting total androgen activity. Complete coding region of the SRD5A2 gene was sequenced in a group of 628 patients and 244 control samples from three southern states (Tamil Nadu, Andhra Pradesh, and Karnataka) of India. We observed three common polymorphisms in this gene namely, A49T, V89L, and (TA)n repeats. A49T locus was monomorphic in the study population, but V89L showed a strong correlation with breast cancer (P=0.03, OR=1.40, CI=1.02-1.91). (TA)0/(TA)9 and (TA)9/(TA)9 genotypes were at a lower risk of breast cancer (P=0.01, OR=0.64, CI=0.46-0.90). We conclude that SRD5A2 genotypes significantly affect breast cancer risk in the South Indian populations.

AB - Androgens in breast cancer have been studied alone and in correlation with estrogens as estrogen to testosterone ratio. 5-α-reductase is one of the important enzymes participating in androgen metabolism, which affects androgen activity by affecting conversion of testosterone to dihydrotestosterone. We hypothesized that polymorphisms in the SRD5A2 gene (encoding 5-α-reductase) may affect breast cancer risk by affecting total androgen activity. Complete coding region of the SRD5A2 gene was sequenced in a group of 628 patients and 244 control samples from three southern states (Tamil Nadu, Andhra Pradesh, and Karnataka) of India. We observed three common polymorphisms in this gene namely, A49T, V89L, and (TA)n repeats. A49T locus was monomorphic in the study population, but V89L showed a strong correlation with breast cancer (P=0.03, OR=1.40, CI=1.02-1.91). (TA)0/(TA)9 and (TA)9/(TA)9 genotypes were at a lower risk of breast cancer (P=0.01, OR=0.64, CI=0.46-0.90). We conclude that SRD5A2 genotypes significantly affect breast cancer risk in the South Indian populations.

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Francis A, Sarkar S, Pooja S, Surekha D, Rao DR, Rao L et al. SRD5A2 gene polymorphisms affect the risk of breast cancer. Breast. 2014;23(2):137-141. https://doi.org/10.1016/j.breast.2013.11.010