Stability indicating HPLC method for venlafaxine hydrochloride capsules

R. Vijayaraghavan, S. Radha, G. Shenoy Gautham, S. Jain, L. Vaidya, F. Ahmad

Research output: Contribution to journalArticle

Abstract

A stability indicating HPLC method for the analysis of venlafaxine hydrochloride in its pharmaceutical dosage forms is developed employing Kromasil C18 column, mobile phase consisted of sodium acetate buffer-acetonitrile (65:35) with UV-detection at 226 nm. The method was validated as per ICH guidelines for specificity, linearity, precision and accuracy. Forced degradation studies were performed on the bulk sample using 0.5 N HCl, 0.1 N NaOH, 33 % H2O2 and heat (50°C).
Original languageEnglish
Pages (from-to)6297-6300
Number of pages4
JournalAsian Journal of Chemistry
Volume20
Issue number8
Publication statusPublished - 2008

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Sodium Acetate
Dosage Forms
Capsules
Buffers
Degradation
Pharmaceutical Preparations
acetonitrile
Hot Temperature
Venlafaxine Hydrochloride

Cite this

Vijayaraghavan, R., Radha, S., Shenoy Gautham, G., Jain, S., Vaidya, L., & Ahmad, F. (2008). Stability indicating HPLC method for venlafaxine hydrochloride capsules. Asian Journal of Chemistry, 20(8), 6297-6300.
Vijayaraghavan, R. ; Radha, S. ; Shenoy Gautham, G. ; Jain, S. ; Vaidya, L. ; Ahmad, F. / Stability indicating HPLC method for venlafaxine hydrochloride capsules. In: Asian Journal of Chemistry. 2008 ; Vol. 20, No. 8. pp. 6297-6300.
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note = "Export Date: 10 November 2017 CODEN: AJCHE Correspondence Address: Radha, S.; School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior-474 011, India; email: sharma.radha@rediffmail.com References: Kuss, H.J., (1986) Practice of High Performance Liquid Chromatography, 94, p. 7. , ed, H. Engelhard, Springer Berlin; Tripathi, K.D., (1999) Essentials of Medical Pharmacology, Jaypee Publishers, 419, p. 4; Labat, L., Deveaux, M., Dallet, P., Dubost, J.P., (2002) J. Chromatogr. B, 773, p. 17; Langford, N.J., Ruprah, M.M., Ferner, R.E., (2002) J. Clin. Pharm. Ther, 465, p. 7; Matoga, M., Pehoureq, F., Titier, K., Dumaro, F., Jarry, C., (2001) J. Chromatogr, 213; Reis, M., Lundmark, J., Bjork, F., (2002) Ther. Drug Monit, 545, p. 24; Tournel, G., Houdret, N., Hedouin, V., Deveau, M., Gosset, D., Lhermitte, M., (2001) J. Chromatogr. B, 761, p. 143; Veefkind, A.H., Hoffmans, P.M.J., Hoenecamp, E., (2000) Ther. Drug Monit, 202, p. 22; Waschgier, R., Hubmann, M.R., Conca, A., Moll, W., Konig, P., (2002) Int. J. Clin. Pharm. Ther, 545, p. 40; Hicks, D.R., Wolanimik, D., Russel, Cavanaugh, N., Krami, N.M.A., (1994) Ther. Drug Monit, 100, p. 16; Vu, R.L., Helmeste, D., Albers, L., Reist, C., (1997) J. Chromatogr. B, 195, p. 703; Waschgler, R., Moll, W., Konig, P., Conca, A., (2004) Int. J. Clin. Pharmcol. Ther, 724, p. 42; Mandrioli, R., Mercolini, L., Cesta, R., Fanali, S., Amore, M., Raggi, M.A., (2007) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 856, p. 88; Asafu-Adjaye, E.B., Faustino, P.J., Tawakkul, M.A., Anderson, L.W., Yu, L.X., Kwon, H., Volpe, D.A., (2007) J. Pharm. Biomed. Anal, 43, p. 1854; Wei, Z., Bing-Ren, X., Cai-Yun, W., (2007) Biomed. Chromatogr, 21, p. 266; Liu, W., Cai, H.L., Li, H.D., (2007) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 850, p. 405; Liu, W., Wang, F., Li, H.D., (2007) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 850, p. 183; Tzanavaras, P.D., Verdoukas, A., Themelis, D.G., (2005) Anal. Sci, 21, p. 1515; Juan, H., Zhiling, Z., Huande, L., (2005) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 820, p. 33; Makhija, S.N., Vavia, P.R., (2002) J. Pharm. Biomed. Anal, 28, p. 1055",
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Vijayaraghavan, R, Radha, S, Shenoy Gautham, G, Jain, S, Vaidya, L & Ahmad, F 2008, 'Stability indicating HPLC method for venlafaxine hydrochloride capsules', Asian Journal of Chemistry, vol. 20, no. 8, pp. 6297-6300.

Stability indicating HPLC method for venlafaxine hydrochloride capsules. / Vijayaraghavan, R.; Radha, S.; Shenoy Gautham, G.; Jain, S.; Vaidya, L.; Ahmad, F.

In: Asian Journal of Chemistry, Vol. 20, No. 8, 2008, p. 6297-6300.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Stability indicating HPLC method for venlafaxine hydrochloride capsules

AU - Vijayaraghavan, R.

AU - Radha, S.

AU - Shenoy Gautham, G.

AU - Jain, S.

AU - Vaidya, L.

AU - Ahmad, F.

N1 - Export Date: 10 November 2017 CODEN: AJCHE Correspondence Address: Radha, S.; School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior-474 011, India; email: sharma.radha@rediffmail.com References: Kuss, H.J., (1986) Practice of High Performance Liquid Chromatography, 94, p. 7. , ed, H. Engelhard, Springer Berlin; Tripathi, K.D., (1999) Essentials of Medical Pharmacology, Jaypee Publishers, 419, p. 4; Labat, L., Deveaux, M., Dallet, P., Dubost, J.P., (2002) J. Chromatogr. B, 773, p. 17; Langford, N.J., Ruprah, M.M., Ferner, R.E., (2002) J. Clin. Pharm. Ther, 465, p. 7; Matoga, M., Pehoureq, F., Titier, K., Dumaro, F., Jarry, C., (2001) J. Chromatogr, 213; Reis, M., Lundmark, J., Bjork, F., (2002) Ther. Drug Monit, 545, p. 24; Tournel, G., Houdret, N., Hedouin, V., Deveau, M., Gosset, D., Lhermitte, M., (2001) J. Chromatogr. B, 761, p. 143; Veefkind, A.H., Hoffmans, P.M.J., Hoenecamp, E., (2000) Ther. Drug Monit, 202, p. 22; Waschgier, R., Hubmann, M.R., Conca, A., Moll, W., Konig, P., (2002) Int. J. Clin. Pharm. Ther, 545, p. 40; Hicks, D.R., Wolanimik, D., Russel, Cavanaugh, N., Krami, N.M.A., (1994) Ther. Drug Monit, 100, p. 16; Vu, R.L., Helmeste, D., Albers, L., Reist, C., (1997) J. Chromatogr. B, 195, p. 703; Waschgler, R., Moll, W., Konig, P., Conca, A., (2004) Int. J. Clin. Pharmcol. Ther, 724, p. 42; Mandrioli, R., Mercolini, L., Cesta, R., Fanali, S., Amore, M., Raggi, M.A., (2007) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 856, p. 88; Asafu-Adjaye, E.B., Faustino, P.J., Tawakkul, M.A., Anderson, L.W., Yu, L.X., Kwon, H., Volpe, D.A., (2007) J. Pharm. Biomed. Anal, 43, p. 1854; Wei, Z., Bing-Ren, X., Cai-Yun, W., (2007) Biomed. Chromatogr, 21, p. 266; Liu, W., Cai, H.L., Li, H.D., (2007) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 850, p. 405; Liu, W., Wang, F., Li, H.D., (2007) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 850, p. 183; Tzanavaras, P.D., Verdoukas, A., Themelis, D.G., (2005) Anal. Sci, 21, p. 1515; Juan, H., Zhiling, Z., Huande, L., (2005) J. Chromatogr. B Anal. Technol. Biomed. Life Sci, 820, p. 33; Makhija, S.N., Vavia, P.R., (2002) J. Pharm. Biomed. Anal, 28, p. 1055

PY - 2008

Y1 - 2008

N2 - A stability indicating HPLC method for the analysis of venlafaxine hydrochloride in its pharmaceutical dosage forms is developed employing Kromasil C18 column, mobile phase consisted of sodium acetate buffer-acetonitrile (65:35) with UV-detection at 226 nm. The method was validated as per ICH guidelines for specificity, linearity, precision and accuracy. Forced degradation studies were performed on the bulk sample using 0.5 N HCl, 0.1 N NaOH, 33 % H2O2 and heat (50°C).

AB - A stability indicating HPLC method for the analysis of venlafaxine hydrochloride in its pharmaceutical dosage forms is developed employing Kromasil C18 column, mobile phase consisted of sodium acetate buffer-acetonitrile (65:35) with UV-detection at 226 nm. The method was validated as per ICH guidelines for specificity, linearity, precision and accuracy. Forced degradation studies were performed on the bulk sample using 0.5 N HCl, 0.1 N NaOH, 33 % H2O2 and heat (50°C).

M3 - Article

VL - 20

SP - 6297

EP - 6300

JO - Asian Journal of Chemistry

JF - Asian Journal of Chemistry

SN - 0970-7077

IS - 8

ER -

Vijayaraghavan R, Radha S, Shenoy Gautham G, Jain S, Vaidya L, Ahmad F. Stability indicating HPLC method for venlafaxine hydrochloride capsules. Asian Journal of Chemistry. 2008;20(8):6297-6300.