A stability indicating HPLC method for the analysis of venlafaxine hydrochloride in its pharmaceutical dosage forms is developed employing Kromasil C18 column, mobile phase consisted of sodium acetate buffer-acetonitrile (65:35) with UV-detection at 226 nm. The method was validated as per ICH guidelines for specificity, linearity, precision and accuracy. Forced degradation studies were performed on the bulk sample using 0.5 N HCl, 0.1 N NaOH, 33 % H2O2 and heat (50°C).
|Number of pages||4|
|Journal||Asian Journal of Chemistry|
|Publication status||Published - 2008|
Vijayaraghavan, R., Radha, S., Shenoy Gautham, G., Jain, S., Vaidya, L., & Ahmad, F. (2008). Stability indicating HPLC method for venlafaxine hydrochloride capsules. Asian Journal of Chemistry, 20(8), 6297-6300. https://www.scopus.com/inward/record.uri?eid=2-s2.0-53949097162&partnerID=40&md5=a2c9b99fc98927e88a36293f251043f8