Stability indicating HPLC method for venlafaxine hydrochloride capsules

R. Vijayaraghavan, S. Radha, G. Shenoy Gautham, S. Jain, L. Vaidya, F. Ahmad

Research output: Contribution to journalArticlepeer-review

Abstract

A stability indicating HPLC method for the analysis of venlafaxine hydrochloride in its pharmaceutical dosage forms is developed employing Kromasil C18 column, mobile phase consisted of sodium acetate buffer-acetonitrile (65:35) with UV-detection at 226 nm. The method was validated as per ICH guidelines for specificity, linearity, precision and accuracy. Forced degradation studies were performed on the bulk sample using 0.5 N HCl, 0.1 N NaOH, 33 % H2O2 and heat (50°C).
Original languageEnglish
Pages (from-to)6297-6300
Number of pages4
JournalAsian Journal of Chemistry
Volume20
Issue number8
Publication statusPublished - 2008

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